2021
DOI: 10.3390/antiox10081173
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Prevention of Teratogenesis in Pregnancies of Obese Rats by Vitamin E Supplementation

Abstract: Congenital malformations are a common adverse outcome in pregnancies complicated by pregestational obesity, although the underlying mechanisms are still unrevealed. Our aim was to study the effect of oxidative stress in obesity-induced teratogenesis. Wistar rats were fed a high-fat diet for 13 weeks, with (OE group) or without (O group) vitamin E supplementation. Then, rats were mated and sacrificed at day 11.5 of gestation. Embryos from O dams presented a 25.9 ± 3.5% rate of malformations (vs. 8.7 ± 3.4% in C… Show more

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Cited by 5 publications
(3 citation statements)
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“…Advanced Oxidation Protein Products (AOPP) are uremic toxins generated as a result of the oxidation of proteins by chlorinated oxidants. The AOPPs in the samples were calorimetrically detected by using potassium iodine in an acid environment, as previously described [46]. The AOPP concentrations were expressed as micromoles of Chloramine-T equivalents per mg of analyzed tissue.…”
Section: Determination Of Cell Viabilitymentioning
confidence: 99%
“…Advanced Oxidation Protein Products (AOPP) are uremic toxins generated as a result of the oxidation of proteins by chlorinated oxidants. The AOPPs in the samples were calorimetrically detected by using potassium iodine in an acid environment, as previously described [46]. The AOPP concentrations were expressed as micromoles of Chloramine-T equivalents per mg of analyzed tissue.…”
Section: Determination Of Cell Viabilitymentioning
confidence: 99%
“…Mortality and morbidity were recorded on days 1, 3, 6, 9, 12, and 15. 20 After day 15 of the treatment, the animals were sacrificed under chloroform anaesthesia.…”
Section: Acute Toxicity Screeningmentioning
confidence: 99%
“…Furthermore, embryopathy-susceptible embryos are more prone to induce oxidative stress by high glucose levels. Alcala et al report an interesting study on the effect of oxidative stress in obesity-induced teratogenesis [ 12 ]. The results show that pregestational obesity in rats induces hepatic protein and DNA oxidation and a decline in antioxidant enzymes.…”
mentioning
confidence: 99%