Prevention of Thalassaemia by Genetic Counseling

Abstract

Thalassaemia is the most common inherited disorder in the world with a wide geographical variation in incidence. According to World Health Organization (WHO) at last 30% of Bangladesh population are carrions of Beta thalassaemia and 4.0% are carriers of Hb-E in Bangladesh. It is presumed that approximately 6000 thalassaemic children are born each year in Bangladesh. A recent study showed that carrier state of Hb-E is 6.1% and as high as 40% in Tribal children in Bangladesh. Early genetic, diagnosis, proper counseling, Health Education Community based prevention are necessary for the improvement of this inherited disorder in Bangladesh. Key Words: Thalassaemia; Bangladesh; Early Diagnosis; Counselings; Community Based Prevention; Health Education DOI: http://dx.doi.org/10.3329/akmmcj.v2i2.8169 AKMMC J 2011; 2(2): 26-28

Thalassaemia Prevention: Bangladesh Perspective - A Current Update

“…A genetic counselor must be trained in molecular genetics of thalassaemia and should have sufficient experience and expertise to communicate with and give detail informations about the disease to the patients and family members. 26 According to international rules, counseling has been performed in a non-directive way but direct to the counselee's corner and is based on a private interview. Genetic counseling includes -1.…”

Evaluation of parathyroid function in adult male patients with transfusion dependent thalassemia

“…characterized by complete absence or reduced synthesis of alpha or beta globin chains leading to ineffective erythropoiesis and anemia. It is an autosomal disorder in which point mutation or deletion occur in the alpha or beta globin gene on chromosome 16(alpha) and 11(beta) [4][5][6] . A World Health Organization (WHO) data shows that about 3% population are carrier of beta thalassemia and about 4% population are carrier of Hb-E in Bangladesh.…”

“…A World Health Organization (WHO) data shows that about 3% population are carrier of beta thalassemia and about 4% population are carrier of Hb-E in Bangladesh. Yearly approximately 6000 children are born with thalassemia in Bangladesh 5,7 .…”

Effect of slow breathing exercise on non linear Heart rate variability in transfusion dependent thalassemic patients

“…globally 1 . About six thousand children are born annually with thalassemia in Bangladesh [2][3] . As anemia is the major clinical feature of thalassemia as a result of ineffective erythropoiesis & extramedullary hemolysis, these patients require regular blood transfusion to sustain their life and therefore they become transfusion dependent thalassemic patients 4,5 .…”