Thalassaemia is the most common inherited disorder in the world with a wide geographical variation in incidence. According to World Health Organization (WHO) at last 30% of Bangladesh population are carrions of Beta thalassaemia and 4.0% are carriers of Hb-E in Bangladesh. It is presumed that approximately 6000 thalassaemic children are born each year in Bangladesh. A recent study showed that carrier state of Hb-E is 6.1% and as high as 40% in Tribal children in Bangladesh. Early genetic, diagnosis, proper counseling, Health Education Community based prevention are necessary for the improvement of this inherited disorder in Bangladesh. Key Words: Thalassaemia; Bangladesh; Early Diagnosis; Counselings; Community Based Prevention; Health Education DOI: http://dx.doi.org/10.3329/akmmcj.v2i2.8169 AKMMC J 2011; 2(2): 26-28

Delayed first passage of meconium and also prolongation of meconium passage creates great anxiety among parents. Some study showed that that first passage of meconium is delayed in preterm infants compared to term infants. The difference in duration of meconium passage in term and preterm infant has however never been assessed before. This cross sectional study was carried between July 2010 to December 2010 among 100 Newborn babies ranging from 28 to 42 weeks of gestation who were delivered in the Department of Obstetrics and Gynaecology or admitted in the Department of Neonatology of Dhaka Medical college Hospital were included in the study. Gestational age was determined from first day of last menstruation (when available) and also by using Expanded Ballard Scoring System. In case of any discrepancy of more than 2 weeks, the later was accepted. This study was carrying out to determine the time of first passage of meconium and duration of passage of meconium in term and preterm infants. Out of total 100 infants, 58 were male and 42 were female. The numbers of babies were 21, 28, 25 and 26 in group I, II, III and IV respectively. The mean age at which the babies passed first meconium were 23.5±3.5, 33.0±3.8, 25.7±4.2 and 17.3±4.6 hours in group I, II, III and IV respectively, which was<48 hours irrespective of gestational age. The mean gestational age of the babies who passed meconium for <4 days was 37.1±2.2 weeks. On the contrary, mean gestational age of the babies who passed meconium for>4 days was 32.6±4.3 weeks and this observation was statistically significant (p<0.001). First passage of meconium in all newborn was within 48 hours irrespective of gestational age. Duration of passage of meconium was significantly prolonged among babies with lower gestational age. DOI: http://dx.doi.org/10.3329/akmmcj.v4i1.13677 AKMMC J 2013; 4(1): 6-9

Foreign body aspiration most commonly affects young children, with respiratory symptoms such as wheeze and cough after a choking episode. A careful history and clinical examination can identify those children that need additional investigation including bronchoscopy. However foreign body aspiration can mimic other conditions. The link between choking and subsequent symptoms may not be made by parents. We present a case with a delay in diagnosis, and discuss the appropriate management of suspected foreign body aspiration.Anwer Khan Modern Medical College Journal Vol. 6, No. 2: July 2015, P 47-49

Background: Hemoglobin E disease are the most common structural haemoglobinopathies, reaching its highest frequency in South East Asia and also prevalent in Bangladesh. There are very few data for effective screening of HB E trait. The aim of the study was to analyze hematological profile and RBC indices as a marker of screening for Hb E trait. Methodology:A cross sectional observational study was conducted among 150 subjects at Dhaka Shishu (Children) Hospital from December 2008 to November 2009. On the basis of Hb electrophoresis, all subjects were divided into three groups. Group I comprised of 50 subjects with Hb E trait, group II comprised 51 subjects with ß thalassemia trait and Group III comprised of 49 normal subjects. Result of RBC indices and blood count were compared between Hb E trait and normal study population. Results:In group I the mean age was 29.53 years and the age range was 2-47 years. In group II the mean age was 30.31 years and the range was 1-55 years. In group III the mean age was 21.81 years and the range was 1-52 years. The present study revealed the mean±SD haemoglobin level (g/dl) in group I (E trait) and group III (normal subjects) were 11.76±1.91 and 10.77±1.4 respectively. Statistically no significant difference was found between these 2 groups (P>.05). The mean corpuscular volume (MCV) in mean±SD in group I and group III were 72.89±12.24 fl and 77.35±10.27 fl respectively. No statistical significance was found as P>0.05. The mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) in group I were 24.84±2.71pg & 32.97±2.27 g/dl and in group III were 28.28±2.71 pg & 32.97±2.38 g/dl respectively. There were no significant difference between group I and III regarding MCH and MCHC.The mean RBC count in E trait and normal subject group were 5.01±71 million/cmm and 4.61±0.65 million/cmm respectively. There was no significant difference was found P>0.05. Mean red cell distribution width (RDW) in group I and III were 14.32 ±2.34 and 14.83±1.28 without any statistical difference (P>0.05) Conclusion: In our study there were no diagnostic significance of Blood count and RBC Indices for detection of Hb E trait. More study should be conducted to find out reliable marker of screening for Hb E carrier.Key Words: Hb E Disease, Hb E Trait. ß Thalassemia trait ABSTRACT including South East Asia². The hereditary disorder of haemoglobin usually present as either a reduced rate of production of one or more of the globin chain (thalassaemia) nor those in which there is

Background: The neonatal period is a highly vulnerable time for an infant completing many of the  physiologic adjustments required for life outside the uterus. As a result, there are high rates of morbidity  and mortality. To reduce morbidity and mortality it is essential to know the neonatal disease pattern.  Neonatal disease pattern changes from time to time and place. Analyzing the neonatal admission pattern  helps the policy makers to make the better strategies and health care givers to serve better. Objectives: This study aimed to determine the disease patterns and outcome of patients admitted to the  Neonatal Intensive Care Unit (NICU) of Anwer khan Modern Medical College Hospital, a tertiary care  hospital in Dhaka, between January 2017 to December 2018. Methods: Retrospective data from the medical records of all neonates admitted during the study period  were reviewed and analyzed for age, weight, sex, reason for admission, duration of hospital stay,  diagnosis and final outcome. Results: The total number of neonates admitted during the study period was 262; 164 were male (62.6%), and  98 were female (37.4%). A total of 223 patients (85.12%) wereborn in the hospital while 39 (12.88%) were  born at home. The majority were admitted during the first 48 hours of life (72.2%). A total of 5 patients (2%)  weighed <1000 gm; 53(20.2%) weighed 1000-1500 gm, and 89 (34%) between 1600-2499 gm. Prematurity  and infection were the main reasons for admission (52.7% and 20%, respectively), followed by birth asphyxia  (12%) and neonatal jaundice (6.8%). A total of 206 patients (78.6%) were improved and discharged, 43 left  against medical advice (16.4%), 3 were referred for urgent cardiac intervention (1.1%) and 10 (3.9%) died. Conclusion: Prematurity, neonatal infection and birth asphyxia were the major causes of neonatal  morbidity and mortality. Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 150-158