Prevention of Vitamin K Deficiency Bleeding in Newborns

Zipursky, Alvin

doi:10.1046/j.1365-2141.1999.01104.x

Cited by 99 publications

(90 citation statements)

References 60 publications

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“…route is known to be effective in preventing both early haemorrhagic disease in neonates and late-onset bleeding in older babies (Dam et al, 1952;McNinch and Tripp, 1991;Zipursky, 1999). The efficacy of oral vitamin K is less certain as there is a recognised problem of absorption in some babies, and additional difficulties in compliance with multiple-dose oral regimens (Zipursky, 1999;Wariyar et al, 2000;von Kries et al, 2003).…”

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confidence: 99%

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Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study

et al. 2003

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The relationship between neonatal vitamin K received by the intramuscular (i.m.) route and the development of leukaemia or other cancers was investigated as part of a national case -control study of childhood cancer, using data abstracted from obstetric and neonatal records. The analyses included 2530 children diagnosed with cancer before 15 years of age, 1174 of whom had leukaemia and 4487 control children without cancer. Overall, 39% of cases and 42% of controls had records of i.m. vitamin K administration, while 24% of cases and 22% of controls had no record of whether or not they had received vitamin K. Using subjects who received i.m. vitamin K as the baseline group, our analyses found no association between the administration of i.m. vitamin K and either leukaemia or other cancers as a group. We conclude that there is no convincing evidence that neonatal vitamin K administration, irrespective of the route by which it is given, influences the risk of children developing leukaemia or any other cancer.

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confidence: 99%

“…Given the concerns associated with the administration of i.m. vitamin K, a wide variety of policies now operate throughout the United Kingdom (McNinch, 1997;Zipursky, 1999;Ansell et al, 2001).…”

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confidence: 99%

Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study

et al. 2003

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“…vitamin K is known to be effective in the prevention of both haemorrhagic disease in neonates and late onset vitamin K deficiency bleeding (McNinch and Tripp, 1991;Sutor et al, 1999;Zipursky, 1999). The efficacy of oral vitamin K is less certain and there have been reports that late bleeding may occur in some healthy breast-fed babies in whom no additional risk factors are identified (McNinch and Tripp, 1991;Cornelissen et al, 1997;Sutor et al, 1999;Zipursky, 1999;Wariyar et al, 2000). Controversy concerning prophylactic I.M.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin K and childhood cancer E Roman et al (Anonymous, 1971(Anonymous, , 1978Hall and Pairaudeau, 1987;Handel and Tripp, 1991;Zipursky, 1999). The Bristol case-control study (Golding et al, 1992) was initiated following the unexpected associations observed in a national cohort study between childhood cancer and maternal exposure to pethidine during labour and neonatal exposure to prophylactic drugs, principally vitamin K (route unspecified) (Golding et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Vitamin K and childhood cancer: analysis of individual patient data from six case–control studies

et al. 2002

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To investigate the hypothesis that neonates who receive intramuscular vitamin K are at an increased risk of developing cancer, particularly leukaemia, a pooled analysis of individual patient data from six case -control studies conducted in Great Britain and Germany has been undertaken. Subjects comprised 2431 case children diagnosed with cancer before 15 years of age and 6338 control children. The retrospective assessment of whether or not an individual baby received vitamin K is not straightforward. In many cases no record was found in stored medical notes and two types of analysis were therefore conducted; in the first it was assumed that where no written record of vitamin K was found it had not been given, and in the second, where no written record of administration was found, information on hospital policy and perinatal morbidity was used to 'impute' whether or not vitamin K had been given. In the first analysis, no association was found between neonatal administration of intramuscular. vitamin K and childhood cancer: odds ratios adjusted for mode of delivery, admission to special care baby unit and low birth weight were 1.09 (95% confidence interval 0.92 -1.28) for leukaemia and 1.05 (0.92 -1.20) for other cancers. In the second analysis, the adjusted odds ratios increased to 1.21 (1.02 -1.44) for leukaemia and 1.10 (0.95 -1.26) for other cancers. This shift did not occur in all studies, and when data from the hypothesis generating Bristol study were excluded, the adjusted odds ratios for leukaemia became 1.06 (0.89 -1.25) in the first analysis and 1.16 (0.97 -1.39) when data on prophylaxis imputed from hospital policy and perinatal morbidity were used. We conclude that whilst the broad nature of the diagnostic groups and the poor quality of some of the vitamin K data mean that small effects cannot be entirely ruled out, our analysis provides no convincing evidence that intramuscular vitamin K is associated with childhood leukaemia.

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“…Because vitamin K is fat-soluble, it can only be absorbed from the intestine in the presence of bile salts. The body's capacity to store vitamin K is very low and the half-life of the vitamin K-dependent coagulation factors is short [1]. Because of this, deficiency can occur quickly if the intake is not sufficient.…”

Section: Editorialmentioning

confidence: 99%

Vitamin K Deficiency in the Hospitalized Patient-- Are we Underestimating the Prevalence?

Pathak¹

2014

J Blood Lymph

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Prevention of Vitamin K Deficiency Bleeding in Newborns

Cited by 99 publications

References 60 publications

Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study

Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study

Vitamin K and childhood cancer: analysis of individual patient data from six case–control studies

Vitamin K Deficiency in the Hospitalized Patient-- Are we Underestimating the Prevalence?

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