Preventive activity of ascorbic acid on lead acetate induced cerebellar damaged in adult Wistar rats

Musa, Sunday Abraham; Iliyasu, Musa O.; Hamman, Wilson Oliver; Ibegbu, Augustine Oseloka; Umana, Uduak Emmanuel

doi:10.15208/mhsj.2012.68

Cited by 8 publications

(3 citation statements)

References 11 publications

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“…Compared to the control group, prior treatment with vitamin C, when any tested metal was present, avoided the negative influences of heavy metals on the liver's function measures. Through creating inert complexes and reducing lead toxicity on dopaminergic neurons, vitamin C plays a critical role in the reversal of lead toxicity ( Musa et al, 2012 ). Other experimental studies have reported comparable results on animals subjected to lead acetate and cadmium chloride ( Kini et al, 2011 ; Ibrahim et al, 2012 ; John et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

Vitamin C and/or garlic can antagonize the toxic effects of cadmium on growth performance, hematological, and immunological parameters of growing Japanese quail

Dosoky,

Farag,

Almuraee

et al. 2024

Poultry Science

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Section: Resultsmentioning

confidence: 99%

Vitamin C and/or garlic can antagonize the toxic effects of cadmium on growth performance, hematological, and immunological parameters of growing Japanese quail

Dosoky,

Farag,

Almuraee

et al. 2024

Poultry Science

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“…A recent study corroborates the attenuation of toxicity of early-life (gestational and lactational) Pb exposure in the cerebellum of rat pups upon the supplementation of AA by oral gavage by using the assessments of oxidative stress markers and the antioxidant system, as well as histopathological examinations and tests for neuromotor functions (forelimb grip and negative geotaxis) [ 308 ]. Interestingly, ameliorative effects of AA in Pb poisoning in the cerebellum of adult rats have also been proposed [ 309 ].…”

Section: Aa As a Potential Ameliorative Agent In Pb Neurotoxicitymentioning

confidence: 99%

“…It should be noted that the effect of AA in the restoration of Pb-induced toxicity is not limited to the brain. Indeed, the non-neuronal amelioration of Pb-mediated effects in experimental animals by AA either alone or in combination with other proposed neuroprotective agents has been observed in blood biochemistry and hematological parameters [ 265 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 ], cardiac functions [ 317 ], hepatic physiology [ 277 , 285 , 312 , 318 , 319 , 320 , 321 , 322 , 323 , 324 ], renal functions [ 285 , 310 , 312 , 325 , 326 ], the colon [ 327 ], testicular functions and spermatogenesis [ 285 , 328 , 329 , 330 , 331 , 332 ], sperm morphology and physiology [ 333 ], thyroid hormone synthesis [ 334 ], the lungs [ 335 ], and clastogenicity in bone marrow cells [ 336 , 337 , 338 ]. Readers are suggested to refer to a recent review paper [ 339 ] for a brief overview of the non-neuronal effects of AA in Pb poisoning.…”

Section: Other Non-neuronal Attenuative Effects Of Aa In Pb Poisonmentioning

confidence: 99%

(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Ahmad

Liu

2020

Antioxidants

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Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-pathological brain states. Furthermore, because of its capacity to chelate metal ions, ascorbic acid may particularly serve as a potent therapeutic agent in Pb poisoning. The present review first discusses the major consequences of Pb exposure in children and then proceeds to present evidence from human and animal studies for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity. In doing so, it is hoped that there is a revitalization for further research on understanding the brain functions of this essential, safe, and readily available vitamin in physiological states, as well to justify and establish it as an effective neuroprotective and modulatory factor in the pathologies of the nervous system, including developmental neuropathologies.

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Selenium nanoparticles alleviate lead acetate‐induced toxicological and morphological changes in rat testes through modulation of calmodulin‐related genes expression

Elfakharany

Mohamed

Etewa

et al. 2022

J Biochem & Molecular Tox

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Lead (Pb) is one of the most common toxic heavy metals. It is a well-known testicular toxicant. Selenium nanoparticles (SeNPs) are a more effective form of elemental selenium that reduces drug-induced toxicities. This study aimed to study the possible ameliorating effect of SeNPs on the toxicological and morphological changes in testes of lead acetate intoxicated rats. The study was conducted on 40 adult male albino rats divided into four groups; control, SeNPs-treated, lead acetate-treated, lead acetate and SeNPS treated groups.The concurrent treatment of lead acetate-exposed rats with SeNPs (0.1 mg/kg/ day) for 12 weeks significantly lowered the blood and testicular lead levels, increased serum testosterone, and decreased luteinizing hormone and folliclestimulating hormone to approach control values. In addition, it improved the histopathological, and ultrastructural alterations of the testes and improved the immunohistochemical expression of the c-kit. This was accompanied by maintenance of the testicular oxidant/antioxidant balance and reversing the lead-induced disrupted calmodulin-related genes expression in testicular tissue in the form of downregulation of CAMMK2 and MAP2K6 and upregulation of CXCR4 genes. There was a strong positive correlation between testicular malondialdehyde and MAP2K6 expression level as well as a strong positive correlation between CXCR4 gene expression and the C-kit area %. In conclusion, SeNPs can be considered as a potential therapy for a lead-induced testicular injury.

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Preventive activity of ascorbic acid on lead acetate induced cerebellar damaged in adult Wistar rats

Cited by 8 publications

References 11 publications

Vitamin C and/or garlic can antagonize the toxic effects of cadmium on growth performance, hematological, and immunological parameters of growing Japanese quail

Vitamin C and/or garlic can antagonize the toxic effects of cadmium on growth performance, hematological, and immunological parameters of growing Japanese quail

(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Selenium nanoparticles alleviate lead acetate‐induced toxicological and morphological changes in rat testes through modulation of calmodulin‐related genes expression

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