Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Skin Diseases and Care

Antioxidants as an Epidermal Stem Cell Activator

“…G. lucidum polysaccharides, a major component of G. lucidum , has a wide spectrum of pharmacologic properties, including antioxidant, anti-aging, anti-tumor, anti-inflammatory, anti-depressant, and immunomodulatory activities [ 66 , 67 ]. G. lucidum polysaccharides exhibits antioxidant activity by scavenging ROS and enhancing enzymatic activity of glutathione peroxidase [ 68 , 69 ].…”

“…G. lucidum polysaccharides have been widely used in wound healing and anti-aging skin care products [ 67 ]. G. lucidum polysaccharides attenuated skin flap ischemia-reperfusion injury via thioredoxin-1-dependent antioxidant and anti-apoptotic pathway [ 74 ].…”

Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS

“…One such mushroom, the Ganoderma lucidum , is used across Asia as a nutraceutical and herbal remedy for many different ailments ( Ding et al, 2010 ; Batra et al, 2013 ; Collado Mateo et al, 2015 ; Wang et al, 2018a ; Geng et al, 2019 ). Ganoderma lucidum extract (GLE) has shown therapeutic benefits as an anti-diabetic agent, in breast cancer, and in inflammatory diseases such as colitis ( Martinez-Montemayor et al, 2011 ; Suarez-Arroyo et al, 2013 ; Liu et al, 2015 ; Barbieri et al, 2017 ; Geng et al, 2019 ; Liu and Tie, 2019 ; Yin et al, 2019 ). Studies have also suggested that GLE has a neuroprotective effect and may be a useful therapeutic option for the prevention of AD and PD ( Cheung et al, 2000 ; Zhao et al, 2004 ; Chen et al, 2007 ; Lai et al, 2008 ; Zhou et al, 2010 ; Shen et al, 2013 ; Yoon et al, 2013 ; Wang et al, 2018b ).…”