Preventive Effect of a Lactobacillus
casei Preparation on the
Recurrence of Superficial Bladder
Cancer in a Double-Blind Trial

Y, Aso; Akaza, Hideyuki; Kotake, T; Tsukamoto, Taiji; Imai, Kazuhiro; Naito, Seiji

doi:10.1159/000475138

Cited by 347 publications

(172 citation statements)

References 13 publications

Supporting

Mentioning

161

Contrasting

Unclassified

Order By: Relevance

“…Since these enzymes may be involved in chemical carcinogenesis (Goldin & Gorbach, 1984), this effect could be viewed as bene®cial. Recent research in patients with super®cial transitional cell carcinoma of the bladder indicates that oral administration of L. casei Shirota preparation (3 g per day) signi®cantly reduced the recurrence of this disease after resection without side-effects (Aso et al, 1995). Although this observation is encouraging, further research is required to investigate the possible bene®ts of lower doses in healthy subjects, as used in the present study, before ®nal conclusions can be drawn.…”

Section: Controlmentioning

confidence: 51%

“…Although the underlying mechanisms are not known, it is suggested that inactivation or inhibition of the formation of carcinogens in the intestinal tract is induced (Fernandes et al, 1987). Furthermore, enhancement or stimulation of immune functions have been described, which may also contribute to a decrease in the risk of the development or recurrence of cancer (Friend & Shahani, 1984;Aso et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans

1998

View full text Add to dashboard Cite

Objective: To determine the effect of consumption of milk fermented by Lactobacillus casei strain Shirota (L. casei Shirota) on the composition and metabolic activities of the intestinal micro¯ora, and immune parameters in humans. Subjects: Twenty healthy male subjects aged 40±65 years were selected. Design: A placebo-controlled trial was performed in which 10 subjects were randomly assigned to a control and 10 to a treatment group. During the ®rst and last two weeks of the 8-week study the subjects received a strictly controlled diet without fermented products. The same controlled diet was given during the intermediate 4-week test period but then the treatment group received three times daily 100 ml of fermented milk containing 10 9 CFU L. casei Shirotaaml, whereas the same amount of unfermented milk was given to the subjects in the control group. Results: In comparison to the control group, the consumption of L. casei Shirota-fermented milk resulted in an increase of the Lactobacillus count in the faeces in which the administered L. casei Shirota was predominant at the level of 10 7 CFUag wet faeces. This was associated with a signi®cant increase in Bi®dobacterium counts (P`0.05). Some shifts in the other bacterial species were found, such as a decreased number of Clostridium; however the differences were not statistically different between the treatment and the control groups.The b-glucuronidase and b-glucosidase activities per 10 10 bacteria decreased signi®cantly (P`0.05) at the second week of the 4-week test period with the consumption of L. casei Shirota-fermented milk. Furthermore, the consumption of the fermented milk product resulted in a slight but signi®cant increase in the moisture content of the faecal samples (P`0.05). No treatment effects were observed for any of the immune parameters measured (including natural killer (NK) cell activity, phagocytosis and cytokine production). Conclusions:The results suggest that consumption of L. casei Shirota-fermented milk is able to modulate the composition and metabolic activity of the intestinal¯ora and indicate that L. casei Shirota-fermented milk does not in¯uence the immune system of healthy immunocompetent males.

show abstract

Section: Controlmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans

1998

View full text Add to dashboard Cite

show abstract

“…Furthermore, NK cells contribute to natural defence against viral infection and tumour cells (Roitt, 1997), and mechanisms which enhance NK cell activity are therefore likely to impart a greater ability of these cells to combat neoplastic diseases. While it is dif®cult to correlate a proven health bene®t in humans with a measurable increase in immune function, there is some circumstantial evidence to support the case with probiotic LAB, since dietary consumption of live yoghurt cultures has been shown to reduce intestinal viral infections, and may also reduce tumour growth (Saavedra et al, 1994;Sawamura et al, 1994;Aso et al, 1995;Majamaa et al, 1995;Rafter, 1995). In previous studies, we have demonstrated that dietary consumption of B. lactis can enhance cellular immune function in mice (Gill, 1998;Gill et al, 2000) and that this enhancement correlates with increased resistance to intestinal infection with Salmonella typhimurium (Shu et al, 2000); there is therefore the promising possibility that enhancement of immune function by dietary consumption of B. lactis might also provide disease protection in humans, however this remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses

et al. 2000

View full text Add to dashboard Cite

Objective: To de®ne the cellular basis for immune enhancement by a probiotic lactic acid bacteria strain (Bi®dobacterium lactis HN019); and to determine whether immune enhancement can be optimized by delivery in oligosaccharide-enriched low-fat milk. Design: A double-blind, three-stage before-and-after intervention trial. Setting: Taipei Medical College Hospital, Taipei, Taiwan. Subjects: Fifty healthy Taiwanese citizens (age range 41 ± 81; median 60) randomly allocated to two groups. Interventions: In stage 1 (run-in control stage) all subjects consumed reconstituted low-fat milk (LFM) for 3 weeks; in stage 2 (probiotic intervention) subjects consumed B. lactis in LFM (group A) or B. lactis in lactosehydrolysed LFM (group B) for 3 weeks; in stage 3 all subjects returned to non-supplemented LFM for a further 3 weeks (washout stage). The innate immune functions of two different leucocyte types (polymorphonuclear (PMN) cells and natural killer (NK) cells) were assessed at four time points via in vitro analyses on peripheral blood samples. Results: While consumption of LFM alone had no signi®cant effect on immune responses, stage 2 results indicated signi®cantly enhanced PMN cell phagocytosis and NK cell tumour killing activity following consumption of milk containing B. lactis. These increases levelled off following cessation of B. lactis consumption, but remained above the pre-treatment values. Increases in PMN and NK cell activity were greatest among subjects who consumed B. lactis in lactose-hydrolysed LFM. Conclusions: Dietary consumption of the probiotic bacterium B. lactis HN019 enhanced immune function of two different types of leucocytes; the degree of enhancement was increased by consuming B. lactis in an oligosaccharide-rich substrate. Sponsorship: Financial support was provided by the New Zealand Dairy Board.

show abstract

“…Some other reporters stated that this probiotics induced improvement in murine chronic IBD is associated with the down-regulation of pro-inflammatory cytokines such as IL-6 in LPMC. The safety of this probiotic strain has been demonstrated in a clinical trial (Aso et al 1995). In the same way, it was postulated that Lactobacillus casei str.…”

Section: Discussionmentioning

confidence: 88%

In case of obesity, longevity-related mechanisms lead to anti-inflammation

Kaya

Bayiroğlu

Mıs

et al. 2013

AGE

View full text Add to dashboard Cite

The exact mechanisms which contribute to longevity have not been figured out yet. Our aim was to find out a common way for prompting longevity by bringing together the well-known applications such as food restriction, exercise, and probiotic supplementing in an experimental obesity model. Experimental obesity was promoted in a total of 32 young (2 months old) and 32 aged (16 months old) male Wistar albino rats through 8-week cafeteria diet (salami, chocolate, chips, and biscuits). Old and young animals were divided into groups each consisting of eight animals and also divided into four subgroups as obese control, obese food restriction, obese probiotic-fed and obese exercise groups. Probiotic group diet contained 0.05 %w/total diet inactive and lyophilized Lactobacillus casei str. Shirota. The exercise group was subjected to treadmill running 1 h/day, at 21 m/min and at an uphill incline of 15 % for 5 days a week. Food restriction group was formed by giving 40 % less food than the others. The control group was fed regular pellet feed ad libitum. This program was continued for 16 weeks. Blood samples from all the groups were analyzed for fasting glucose, insulin, IGF-1, insulin-like growth factor binding protein 3 (IGFBP-3), interleukin (IL)-6, IL-12, malondialdehyde (MDA), fT3, TT3, fT4, TT4, and liver tissue MDA levels were measured. All applications showed anti-inflammatory effects through the observed changes in the levels of IGFBP-3, IL-6, and IL-12 in the young and old obese rats. While the interventions normally contribute to longevity by recruiting different action mechanisms, anti-inflammatory effect is the only mode of action for all the applications in the obesity model.

show abstract

Preventive Effect of a Lactobacillus casei Preparation on the Recurrence of Superficial Bladder Cancer in a Double-Blind Trial

Cited by 347 publications

References 13 publications

The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans

The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans

Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses

In case of obesity, longevity-related mechanisms lead to anti-inflammation

Contact Info

Product

Resources

About