Preventive Effect of<i>Zea mays</i>L. (Purple Waxy Corn) on Experimental Diabetic Cataract

Thiraphatthanavong, Paphaphat; Muchimapura, Supaporn; Thukham-mee, Wipawee; Wannanon, Panakaporn; Tong-Un, Terdthai; Suriharn, Bhalang; Lertrat, Kamol

doi:10.1155/2014/507435

Cited by 41 publications

(27 citation statements)

References 22 publications

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“…Supplementation of anthocyanins (50 mg/kg body weight) from the seed coat of black soybean to N-methyl-N-nitrosourea-induced retinal degenerative rats also prevents retinal degeneration [94], and also suppresses human lens epithelial cell death under hydrogen peroxide-induced oxidative stress by 50–200 μg/ml of the extract [93]. Anthocyanin also predominates around 70% in purple corn seed [124], where purple corn seed extract decreases lens opacity together with lower malonaldehyde levels [92]. …”

Section: Nutraceutical and Pharmaceutical Effects Of Anthocyaninsmentioning

confidence: 99%

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Khoo

Azlan

Tang

et al. 2017

Food & Nutrition Research

2,068

1,327

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Anthocyanins are colored water-soluble pigments belonging to the phenolic group. The pigments are in glycosylated forms. Anthocyanins responsible for the colors, red, purple, and blue, are in fruits and vegetables. Berries, currants, grapes, and some tropical fruits have high anthocyanins content. Red to purplish blue-colored leafy vegetables, grains, roots, and tubers are the edible vegetables that contain a high level of anthocyanins. Among the anthocyanin pigments, cyanidin-3-glucoside is the major anthocyanin found in most of the plants. The colored anthocyanin pigments have been traditionally used as a natural food colorant. The color and stability of these pigments are influenced by pH, light, temperature, and structure. In acidic condition, anthocyanins appear as red but turn blue when the pH increases. Chromatography has been largely applied in extraction, separation, and quantification of anthocyanins. Besides the use of anthocyanidins and anthocyanins as natural dyes, these colored pigments are potential pharmaceutical ingredients that give various beneficial health effects. Scientific studies, such as cell culture studies, animal models, and human clinical trials, show that anthocyanidins and anthocyanins possess antioxidative and antimicrobial activities, improve visual and neurological health, and protect against various non-communicable diseases. These studies confer the health effects of anthocyanidins and anthocyanins, which are due to their potent antioxidant properties. Different mechanisms and pathways are involved in the protective effects, including free-radical scavenging pathway, cyclooxygenase pathway, mitogen-activated protein kinase pathway, and inflammatory cytokines signaling. Therefore, this review focuses on the role of anthocyanidins and anthocyanins as natural food colorants and their nutraceutical properties for health. Abbreviations: CVD: Cardiovascular disease VEGF: Vascular endothelial growth factor

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Section: Nutraceutical and Pharmaceutical Effects Of Anthocyaninsmentioning

confidence: 99%

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Khoo

Azlan

Tang

et al. 2017

Food & Nutrition Research

2,068

1,327

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show abstract

“…Epidemiological studies have demonstrated a relationship between the consumption of food with high quantities of phenolic compounds and a reduction in the risks of chronic and degenerative diseases, such as cancers and cardiovascular disease. Corn seed possesses antidiabetic, antioxidant, antiproliferative, and anti-cataractogenic activities [18,[39][40][41].…”

Section: Biological Activitiesmentioning

confidence: 99%

“…The toxicological assessment of corn at various doses against various clinical parameters has proven it clinically nontoxic and can be used for nutritional and medicinal purposes [53]. Anthocyanins in purple waxy corn have been reported to be effective against diabetic cataract [39]. Corn silk is usually discarded as waste and not used for nutritional purpose.…”

Section: Medicinal Importancementioning

confidence: 99%

Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn

Nawaz¹,

Muzaffar²,

Aslam³

et al. 2018

Corn - Production and Human Health in Changing Climate

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Corn seeds are used as a nutritional source for humans, and the stem and leaves are utilized as fodder for cattle throughout the world. Corn silk and corn cob are usually discarded as waste. This chapter highlights the nutritional as well as medicinal importance of various parts of corn plant. All parts of corn plant are good source of a variety of bioactive phytochemical compounds which possess antioxidant potential. The principal phytochemicals present in corn seed and corn silk include polyphenols, phenolic acids, flavonoids, anthocyanins, glycosides, carotenoids, and polysaccharides of biological importance, reducing compounds and some water-soluble vitamins. The presence of these phytochemicals makes corn a medicinal plant which shows various biological activities particularly the antioxidant, antimicrobial, antidiabetic, anti-obesity, antiproliferative, hepatoprotective, cardioprotective, and renal-protective activities. On the account of its high antioxidant potential, all parts of corn plant can be used for the management of oxidative stress and the treatment of various diseases.

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“…Aldose reductase (AR) activity was assessed by using spectroscopy with the method of Thiraphatthanavong et al (2014) . Here DL‐glyceraldehyde was used as a substrate.…”

Section: Methodsmentioning

confidence: 99%

Losartan delays the progression of streptozotocin‐induced diabetic cataracts in albino rats

Shree

Choudhary

Bodakhe

2019

J Biochem & Molecular Tox

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The ocular renin‐angiotensin system has become an interesting target for ocular diseases because it has been implicated in various ocular diseases such as diabetic retinopathy, glaucoma, age‐related macular degeneration, uveitis, and hypertensive cataracts. In the present study, we explored the effect of topically and orally administered losartan (an angiotensin receptor blocker) on streptozotocin‐induced diabetic cataract in albino rats. Topical treatment with losartan modulated neither the blood glucose level nor the polyol content but oral treatment with losartan decreased both. Topical and oral treatment with losartan significantly increased the antioxidants (glutathione, glutathione peroxidase, superoxide dismutase, and catalase), decreased the lipid peroxidant malondialdehyde, and restored soluble protein, and insoluble protein and various ions (Na+, K+, and Ca2+) in the lens; however, topical treatment had a better effect than oral treatment. These findings demonstrate that topical administration of losartan significantly reduces the risk of cataract formation without affecting either the blood glucose level or polyol contents.

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Preventive Effect ofZea maysL. (Purple Waxy Corn) on Experimental Diabetic Cataract

Cited by 41 publications

References 22 publications

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn

Losartan delays the progression of streptozotocin‐induced diabetic cataracts in albino rats

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