Preventive effect of l-carnosine on ischemia/reperfusion-induced acute renal failure in rats

Renoprotective Effects of l-Carnosine on Ischemia/Reperfusion-Induced Renal Injury in Rats

“…We have found that RSNA is significantly augmented during renal ischemia and that ischemic ARF is ameliorated by renal denervation or ganglionic blockade and that the effect is accompanied by suppression of elevated renal venous NE levels immediately after reperfusion (Fujii et al, 2003a). Similar suppressive effects on renal venous NE levels have already observed in ischemic ARF rats given l-carnosine (Fujii et al, 2003b); however, it remains unknown whether this peptide can suppress enhanced RSNA during the renal ischemia. Yamano et al (2001) reported that both central and peripheral administration of l-carnosine inhibited neural activities of sympathetic nerves innervating the adrenal gland and liver in anesthetized rats.…”

“…l-Carnosine is known to possess free radical scavenging functions (Dahl et al, 1988;Hartman et al, 1990) and to exert neuroprotective and cardioprotective effects in pheochromocytoma PC12 cells and cardiomyoblasts exposed to hypoxia/reoxygenation, respectively (Bharadwaj et al, 2002;Tabakman et al, 2002). Moreover, it has been demonstrated that l-carnosine reduces mortality in rats after global brain ischemia (Stvolinsky et al, 2000) and overcomes ischemia/reperfusion (I/R)-induced acute renal failure (ARF) in rats (Fujii et al, 2003b).…”

Retraction：Dietary Supplementation of L-Carnosine Prevents Ischemia/Reperfusion-Induced Renal Injury in Rats

“…bolus injection of L-carnosine (1-10 mg/kg). 10) Taken together, it is reasonable to consider that the beneficial effect of L-carnosine feeding on the ischemia/reperfusion-induced renal damage is closely related to the suppressive action on the renal sympathetic nerve activity, although further studies are needed to determine whether antioxidative characteristics of L-carnosine is involved in the renoprotective effect.…”

“…8,9) Most recently, we found that an intravenous bolus injection of L-carnosine attenuated the post-ischemic renal injury in rats. 10) Furthermore, dietary L-carnosine feeding to rats efficiently suppressed the development of hypertension induced by deoxycorticosterone acetate and salt. 11) In addition, we observed also an inhibitory effect of L-carnosine on the neural activity of the renal sympathetic nerve, 11) which is closely related to the antihypertensive effect of L-carnosine.…”

Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice

“…It is hypothesized that PEPT2 ablation will have a profound impact on the systemic pharmacokinetics of carnosine, as well as on the regional exposure of carnosine in kidney and brain. Differences in PEPT2-mediated disposition may also alter the physiological and pharmacological benefits of carnosine, including its renal (7,14) and neuroprotective (22,29) effects after ischemic insult.…”