Preventive effect of lacrimal occlusion on topical timolol‐induced bronchoconstriction in asthmatics

Hepşen, İbrahim F.; Yıldırım, Zeki; Yılmaz, Harun; Kotuk, Mahir

doi:10.1111/j.1442-9071.2004.00909.x

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…This route of systemic absorption of biologically active compound avoids the first‐pass effect normally observed after oral presentation of a compound, and the pharmacological sequelae resemble those seen after an intravenous administration. This pharmacokinetic phenomenon has been given in clinical situations with topical administration of antiglaucoma medicines to the eye, because the systemic effects of drugs such as timolol can be quite pronounced [56].…”

Section: Resultsmentioning

confidence: 99%

Novel intraocular and systemic absorption drug delivery and efficacy of N‐acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care

Babizhayev

Хорошилова-Маслова

Kasus‐Jacobi

2011

Fundamemntal Clinical Pharma

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The latest estimates of the World Health Organization indicate that there are 161 million visually impaired individuals worldwide, 37 million of whom are blind, with a yearly increase of 1-2 million. The scientists developed and patented the lubricant eye drops formulated as 1%N-acetylcarnosine prodrug of l-carnosine containing a mucoadhesive cellulose-based compound combined with corneal absorption promoters in an ocular drug delivery system. Carcinine is suitable for the systemic administration (per oral) for ophthalmic therapeutic indications. The HPLC analysis was developed to search the pathways of ocular metabolic activities of 1%N-acetylcarnosine and the bioactivation of this drug molecule promoting transcorneal uptake of l-carnosine in the aqueous humor. A meta-analysis of phase 2 randomized double-blind placebo-controlled clinical trial data was conducted. The intraocular absorbed l-carnosine demonstrated a number of pharmacological mechanisms of prevention and reversal of cataracts. Results of systemic absorption of l-carnosine provide tuberomammillary activation that regulates neuronal functions such as hypothalamic control promoting sensory input in the primary vision perceptual pathway. The parabulbar, subconjunctival, and intravitreal injection of carcinine with most of the vehicle removed is not toxic to intraocular structures, reduces postoperative intraocular inflammation, is a potentially useful tool in the treatment of proliferative vitreoretinopathy as well as considered as the antiapoptotic drug for the protection of photoreceptor cells from oxidative light-induced stress. The discovery of naturally occurring carnosine derivatives introduces N-acetylcarnosine and carcinine as effective medical treatment for sight-threatening eye disorders.

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Section: Resultsmentioning

confidence: 99%

Novel intraocular and systemic absorption drug delivery and efficacy of N‐acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care

Babizhayev

Хорошилова-Маслова

Kasus‐Jacobi

2011

Fundamemntal Clinical Pharma

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“…Plasma levels of ocular drugs are lower when lacrimal occlusion is applied with punctal occlusion or with fi nger pressure immediately after installation of any eyedrop. 21,22 In conclusion, glaucoma treatment with latanoprost seems to be safer in elderly people in comparison with the timolol treatment. Even if they have no history of airways disease, some deterioration can occur in the respiratory and cardiovascular systems due to beta-blocker therapy.…”

Section: Methodsmentioning

confidence: 96%

Effects of Timolol and Latanoprost on Respiratory and Cardiovascular Status in Elderly Patients With Glaucoma

Ergin

Örnek

Güllü

et al. 2009

Journal of Ocular Pharmacology and Therapeutics

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“…Nasolacrimal duct occlusion by hand or by silicone plugs has been shown to increase the therapeutic index of several glaucoma drugs 19 and decrease their systemic effects. 20,21 Using timolol in a gel formulation allowed once daily dosing 22 with decreased systemic absorption. 23 The Corneal Barrier…”

Section: Precorneal Tear Drainagementioning

confidence: 99%

Barriers to Glaucoma Drug Delivery

Ghate

Edelhauser

2008

Journal of Glaucoma

132

100

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Topical medications remain the mainstay of glaucoma treatment. This review will aim to cover the pharmacokinetics of topically applied drops, the ocular barriers to drug delivery, and the role of ophthalmic drug formulation in enhancing drug delivery to the target tissue while minimizing side effects and increasing patient compliance. Recent advances in surgical techniques, therapeutic approaches, and material sciences have produced exciting new therapies for ocular diseases. The development of new vehicles and drug formulations that require less patient compliance is also discussed, as are the routes of drug delivery for neuroprotection.

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Preventive effect of lacrimal occlusion on topical timolol‐induced bronchoconstriction in asthmatics

Abstract: Lacrimal occlusion with intracanalicular collagen plugs may almost completely prevent the bronchoconstriction caused by topical timolol in asthmatics by inhibiting or decreasing systemic absorption of the medication.

Cited by 11 publications

References 23 publications

Novel intraocular and systemic absorption drug delivery and efficacy of N‐acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care

Novel intraocular and systemic absorption drug delivery and efficacy of N‐acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care

Effects of Timolol and Latanoprost on Respiratory and Cardiovascular Status in Elderly Patients With Glaucoma

Barriers to Glaucoma Drug Delivery

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