Preventive effect of Rhus javanica extract on UVB-induced skin inflammation and photoaging

Ha, Seunggyun; Lee, Jangho; Kim, Hyojin; Song, Kyung‐Mo; Lee, Nam Hyouck; Kim, Young Eon; Lee, Hookeun; Kim, Yong Ho; Jung, Sung Keun

doi:10.1016/j.jff.2016.10.011

Cited by 19 publications

(22 citation statements)

References 32 publications

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“…induction is known to be responsible for UV-induced damage to skin connective tissue, as well as inflammation [30]. Previous studies have reported that the extract of Rhus javanica attenuates UVB-dependent photodamage and inflammation is known to affect the expression of MMPs and COX-2 in SKH-1 hairless mice [31]. As expected, RBS prevented chronic UV-induced upregulation of COX-2 and MMP-13 levels in the mouse skin.…”

Section: Rbs Inhibits Uvb-induced Mmp-13 and Cox-2 Upregulation In Mosupporting

confidence: 58%

Rice bran supplement prevents UVB-induced skin photoaging in vivo

Park

Lee

et al. 2018

Bioscience, Biotechnology, and Biochemistry

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Although rice bran consumption is reportedly has numerous beneficial effects on human health, the relationship between rice bran and the prevention of photoaging has not been investigated in detail. We sought to investigate whether consumption of rice bran supplement (RBS) can elicit preventive effects against UVB-induced photoaging in vivo. Dorsal skin sections of hairless mice were exposed to UVB over 16 weeks. RBS consumption suppressed UVB-induced wrinkle formation and inhibited the loss of water content and epidermal thickening in the mouse skin. Western blot and immunohistochemical analyses revealed that repeated exposure to UVB upregulated matrix metalloproteinase-13 (MMP-13) and cyclooxygenase-2 (COX-2) expression, while consumption of RBS suppressed MMP-13 and COX-2 expression, as well as mitogen-activated protein kinase (MAPK) signaling pathways. These findings suggest that RBS could be a potential bioactive ingredient in nutricosmetics to inhibit wrinkle formation and water content loss via the suppression of COX-2 and MMP-13 expression.

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Section: Rbs Inhibits Uvb-induced Mmp-13 and Cox-2 Upregulation In Mosupporting

confidence: 58%

Rice bran supplement prevents UVB-induced skin photoaging in vivo

Park

Lee

et al. 2018

Bioscience, Biotechnology, and Biochemistry

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“…UV exposure is a primary cause of skin inflammation and aging, and natural product-derived compounds are often utilized in skin disease treatment and cosmetic formulations [21,22]. Skin inflammation caused by UVB is a multistep process, including COX-2 mediating PGE 2 production and TNF-α IP-2 mediating TNF-α production [23].…”

Section: Discussionmentioning

confidence: 99%

Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge Spongosorites genitrix, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells

et al. 2020

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Skin is an important barrier to protect the body from environmental stress. However, exposure to ultraviolet radiation (UV) and various environmental oxidative stresses can cause skin inflammation. Cyclooxygenase-2 (COX-2) is an inducible enzyme that mediates the formation of prostaglandin E2 (PGE2) against internal and external inflammatory stimulations. Therefore, the inhibition of COX-2 is an important approach to maintain skin health and prevent skin inflammation and carcinogenesis. Topsentin, a bis(indolyl)imidazole alkaloid isolated from the marine sponge Spongosorites genitrix, has been reported to exhibit anti-tumor and anti-microbial activities. However, the effect of topsentin on skin inflammation and its underlying molecular mechanism has not been elucidated. In the present study, we identified the photoprotective effects of topsentin on UVB irradiated human epidermal keratinocyte HaCaT cells. Topsentin suppresses COX-2 expression and its upstream signaling pathways, AP-1 and MAPK. Furthermore, topsentin inhibits miR-4485, a new biomarker selected from a microarray, and its target gene tumor necrosis factor alpha induced protein 2 (TNF-α IP2). The photoprotective effect of topsentin was also confirmed in a reconstructed human skin model. These findings suggest that topsentin may serve as a potential candidate for cosmetic formulations with skin inflammatory-mediated disorder.

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“…Based on the principle, each species of nature has its own characteristics. The major phenolic compounds of Rhus Javanica have been reported as were Gallic acid, methyl gallate, syringic acid, pentagalloylglucose, and protocatechuic acid 7 . Due to its chemical compound, polyphenols had potent antioxidants to scavenge Reactive Oxygen Species (ROS).…”

Section: Discussionmentioning

confidence: 99%

“…The five major phenolic compounds were successfully identified using LC-MS (Liquid chromatography-mass spectrometry) as gallic acid, methyl gallate, syringic acid, pentagalloylglucose, and protocatechuic acid. Those chemical substances might have strong protective effects against oxidative damage which might cause a serious disease and aging process 7 . In an other report, there were seven phytochemicals which were isolated from nutgall stem bark of Rhus javanica.…”

Section: Introductionmentioning

confidence: 99%

Anti-elastase, Antioxidant, Total phenolic and Total Flavonoid Content of Macassar Kernels (Rhus javanica L) from Pananjung Pangandaran Nature Tourism Park- Indonesia

Anggraini

Elya

Iskandarsyah

2020

Journal of Natural Remedies

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Background: Phytochemicals are present as important substances in natural resources and therefore, have aided in invention of the anti-oxidant, and anti-elastase properties of polyphenol compounds present in Indonesian herbs such as Macassar Kernels (Rhus javanica L). Objective: This research aimed to investigate anti-elastase, and antioxidant properties. Methods: Ethanolic extract of Rhus Leaves (RL), Rhus Stem (RS), Rhus Greenish Fruit (RGF), and Rhus Blackish-grey Fruit (RBF) were prepared individually by solvent extraction method. Anti-elastase activity was carried out with elastase from porcine pancreas. For quantitative phytochemical screening, DPPH radical scavenging assay, Ferric Reducing Antioxidant Power Assay (FRAP), Total Phenolic Content (TPC), Total Flavonoid Content (TFC) of Rhus javanica were estimated. Result: RS showed highest anti-elastase activity (45.30%±0.087), compared with RL (12.30%±0.004), and there were no activities in RGF and RBF. In DPPH assay, RS had lowest activity (IC50 561.05 µg/ml), compared with RBF (IC50 239.28 µg /ml), RGF (IC50 189.3I µg/ml), and RL (IC50 157.81 µg/ml). RS also has lowest FRAP activity (% inhibition = 26.60%±0.002), and TPC value (28.50±0.03 mgGAE/g dry weight). Conclusion: Test extracts showed anti-aging properties in different mechanisms. RS possessed the highest anti-elastase activity but had the weakest antioxidant activity. RS (Rhus Stem) TFC (Total Flavonoid Content) TPC (Total Phenolic Content) TPTZ (2, 4, 6-tris(2-pyridyl)-striazine) Q (Quercetin)

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Preventive effect of Rhus javanica extract on UVB-induced skin inflammation and photoaging

Cited by 19 publications

References 32 publications

Rice bran supplement prevents UVB-induced skin photoaging in vivo

Rice bran supplement prevents UVB-induced skin photoaging in vivo

Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge Spongosorites genitrix, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells

Anti-elastase, Antioxidant, Total phenolic and Total Flavonoid Content of Macassar Kernels (Rhus javanica L) from Pananjung Pangandaran Nature Tourism Park- Indonesia

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