Preventive effect of taurine against acute paraquat intoxication in beagles.

Izumi, Kanji; Nagata, Ryoichi; Motoya, Toshiro; Yamashita, Jun‐ichi; Hirokane, Taminori; Nagata, Takahisa; Satoh, Yohji; Sawada, Yuhsuke; Ishibashi, Maruo; Yoshida, Hiroki; Fukuda, Takeo

doi:10.1254/jjp.50.229

Cited by 12 publications

(5 citation statements)

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“…We hypothesized that the possible mechanism of the protective effects of taurine was via its antioxidative [29]. Based on other reports in another system [11,30,31], we found that taurine inhibits proinflammatory cytokine production in cerulein-induced pancreatitis. For these purposes, we assayed MDA as an indicator for oxidative tissue damage, and for IL-1ß and TNF-·, which are proinflammatory cytokines and known to be increased in acute cerulein-induced pancreatitis [24,25,32,33].…”

Section: Discussionmentioning

confidence: 65%

Effects of Taurine on Cerulein-Induced Acute Pancreatitis in the Rat

Ahn

Kim²,

Lee³

et al. 2001

Pharmacology

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Taurine, or 2-aminoethane sulfonic acid, is an intracellular amino acid and has been suggested to have a function in protecting biological systems from oxidative tissue damage. The aim of this study was to determine the effect of taurine against cerulein-induced acute pancreatitis in rats. Acute pancreatitis was induced by administering three subcutaneous injections of cerulein (40 µg/kg body weight) at 1-hour intervals, while taurine was administered intravenously at graded doses (30, 100, or 300 mg/kg, respectively) following the first cerulein injection. The severities of pancreatitis and lung injury were determined by measuring biochemical parameters, tissue myeloperoxidase (MPO), and histological changes. To clarify the mechanism of taurine, serum IL-1β and TNF-α levels and tissue concentrations of malondialdehyde (MDA) were evaluated. In cerulein-induced acute edematous pancreatitis, treatment with taurine significantly decreased hyperamylasemia, tissue MPO, pancreatic edema, and the extent of pancreatic and pulmonary injury. Taurine decreased MDA concentration in the pancreas and lung, but not the serum cytokine concentration. We would conclude that taurine has beneficial effects in cerulein-induced acute pancreatitis and lung injuries by preventing the production of oxygen free radicals.

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Section: Discussionmentioning

confidence: 65%

Effects of Taurine on Cerulein-Induced Acute Pancreatitis in the Rat

Ahn

Kim²,

Lee³

et al. 2001

Pharmacology

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“…For example, taurine has been demonstrated to inhibit oxidative stress-induced lung damage ( 264 ), whereas more recently taurine supplementation has been shown to increase the activity of anti-oxidant enzymes in the lungs ( 265 ). In other cases, taurine has shown to exert anti-oxidant activity against bleomycin-induced lung injury ( 266 ) or against amiodarone ( 267 ) or paraquat ( 268 , 269 ) or sumatriptan mediated lipid peroxidation (LPO), and mitochondrial injury ( 270 ). Other studies have indicated that oral supplementation of taurine probably serves as a protective agent against damage mediated by nitrogen dioxide (NO 2 ) ( 271 ).…”

Section: The Anti-oxidant Properties Of Taurine In Various Toxic-mediated Insultsmentioning

confidence: 99%

Protective role of taurine against oxidative stress (Review)

et al. 2021

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Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer protection against oxidant stress. The development of hypertension, muscle/neuroassociated disorders, hepatic cirrhosis, cardiac dysfunction and ischemia/reperfusion are examples of some injuries that are linked with oxidative stress. The present review gives a comprehensive description of all the underlying mechanisms of taurine, with the aim to explain its anti-oxidant actions. Taurine is regarded as a cytoprotective molecule due to its ability to sustain normal electron transport chain, maintain glutathione stores, upregulate anti-oxidant responses, increase membrane stability, eliminate inflammation and prevent calcium accumulation. In parallel, the synergistic effect of taurine with other potential therapeutic modalities in multiple disorders are highlighted. Apart from the results derived from research findings, the current review bridges the gap between bench and bedside, providing mechanistic insights into the biological activity of taurine that supports its potential therapeutic efficacy in clinic. In the future, further clinical studies are required to support the ameliorative effect of taurine against oxidative stress. Contents1. Introduction 2. The role of taurine in homeostasis 3. The role of taurine against oxidative stress and its underlying molecular mechanisms 4. The beneficial effect of taurine against neuro-associated disorders 5. The anti-oxidant efficacy of taurine against cardiacassociated oxidative stress 6. The regulatory importance of taurine in ischemia and reperfusion 7. The anti-oxidant efficacy of taurine against muscle-associated disorders 8. The anti-oxidant efficacy of taurine against hepatic-associated stress 9. The anti-oxidant properties of taurine in various toxicmediated insults 10. Conclusions

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“…This has been particularly well documented in animal models of lung injury. Prophylactic administration of taurine protects lung from damage induced by inhalation exposure to NO 2 (2) or O 3 (3,4) and by intratracheal instillation of bleomycin (5), amidarone (6), or paraquat (7). All of these models of lung damage involve an influx of neutrophils followed by macrophages and production of inflammatory mediators.…”

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confidence: 99%

Taurine Chloramine Inhibits Inducible Nitric Oxide Synthase and TNF-α Gene Expression in Activated Alveolar Macrophages: Decreased NF-κB Activation and IκB Kinase Activity

Barua

Liu

Quinn

2001

The Journal of Immunology

153

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Taurine prevents tissue damage in a variety of models that involve inflammation, including oxidant-induced lung damage. The mechanism of protection is uncertain, but is postulated to involve the actions of taurine chloramine (Tau-Cl) derived via halide-dependent myeloperoxidase associated with neutrophils. Understanding the influence of Tau-Cl on the production of inflammatory mediators by alveolar macrophages provides an opportunity for determining the mechanism of Tau-Cl action. The effects of Tau-Cl were evaluated on the production of NO and TNF-α in NR8383, a cloned cell line derived from rat alveolar macrophages (RAM), and in primary cultures of RAM. Production of NO and TNF-α, and expression of inducible NO synthase was inhibited by Tau-Cl in activated NR8383 cells as well as in RAM. Temporal (2, 4, 8, 24 h) expression of inducible NO synthase and TNF-α mRNAs was reduced by Tau-Cl in NR8383 cells. Tau-Cl depressed NF-κB migration into the nucleus of activated NR8383 cells and caused a more sustained presence of IκB in the cytoplasm. Stabilization of cytoplasmic IκB-α in Tau-Cl-treated cells resulted from decreased phosphorylation of IκB-α serine-32 and a lower activity of IκB kinase (IKK). Additional experiments demonstrated that Tau-Cl does not directly inhibit IKK activity. These results suggest that Tau-Cl exerts its effects at some level upstream of IKK in the signaling pathway and inhibits production of inflammatory mediators through a mechanism that, at least in part, involves inhibition of NF-κB activation.

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Preventive effect of taurine against acute paraquat intoxication in beagles.

Cited by 12 publications

References 12 publications

Effects of Taurine on Cerulein-Induced Acute Pancreatitis in the Rat

Effects of Taurine on Cerulein-Induced Acute Pancreatitis in the Rat

Protective role of taurine against oxidative stress (Review)

Taurine Chloramine Inhibits Inducible Nitric Oxide Synthase and TNF-α Gene Expression in Activated Alveolar Macrophages: Decreased NF-κB Activation and IκB Kinase Activity

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