Preventive effects of carbon dioxide laser and casein phosphopeptide amorphous calcium phosphate fluoride varnish on enamel demineralization: A comparative, in vitro study

Abstract

Aim The aim of the present study was to compare the effects of carbon dioxide (CO2) laser and casein phosphopeptide amorphous calcium phosphate (CPP‐ACP)fluoride varnish on enamel demineralization. Methods Human teeth were randomly assigned to three groups. The enamel was treated with fluoride varnish, 10.6 μm CO2 laser, or no treatment (control), followed by 9 days of pH cycling. Baseline and final FluoreCam images were used to quantify the area, intensity, and impact of demineralization; cross‐sectional microhardness was used to measure the mechanical properties of the enamel. Results There were statistically‐significant changes in the area, intensity and impact of demineralization in the control and laser groups (P < 0.05), but not in the fluoride group. The control group showed a significantly greater area and impact of enamel demineralization compared to the fluoride group. The area of demineralization in the laser group was significantly greater than that of the fluoride group. Enamel demineralization of the laser and control groups was comparable. The fluoride group showed statistically‐significant harder enamel than the control at 20, 40, and 60 μm depths; the laser group enamel was significantly harder than the control at 20 and 40 μm depths. The fluoride group showed statistically‐significant harder enamel than the laser group at 20 μm depth. Conclusions CPP‐ACP fluoride varnish is more effective than CO2 in preventing enamel demineralization.

Efficacy of casein phosphopeptide-amorphous calcium phosphate varnish in remineralizing white spot lesions: A systematic review and meta-analysis

“…[ 19 ] Risk of bias item randomization and allocation concealment were considered low risk as the samples (human teeth enamel) used were homogenous. [ 18 ] Overall, 7[ 26 31 32 34 38 ] of the 18 included studies had unclear risk of bias and rest 11[ 10 11 24 27 29 30 33 35 36 37 39 ] had low risk of bias. The risks of bias of the included studies are summarized in Table 4 [ Figure 3 ].…”

“…CPP-ACPF varnish groups recorded significantly harder enamel than no treatment groups [ Table 5 ]. [ 24 27 28 29 31 32 34 ]…”

“…CPP-ACPF varnish showed superior remineralizing effect when compared to no treatment. [ 11 24 25 26 28 34 36 37 38 39 ] When remineralizing effect of CPP-ACPF varnish was compared to fluoride varnish, superior efficacy was seen in four studies[ 11 33 36 39 ] while two studies[ 34 38 ] did not report a significant effect [ Table 5 ].…”

Effect of Remineralization Potential of ACP&ndash;CPP with Fluoride and ACP&ndash;CPP on Enamel Subsurface Lesion in Primary and Young Permanent Teeth: In situ Study

“…Prevention is the most important tool to manage at caries risk tooth surfaces and incipient caries. These lesions should be treated by noninvasive approach remineralization can be achieved effectively with bioavailable calcium, phosphate, and fluoride ions to restore the strength and esthetic appearance of the lesion 3,4 . Therefore, the present study aimed to compare the remineralization potential of CPP-ACP, CPP-ACP with fluoride and placebo group in an in situ model concerning enamel subsurface lesion in primary and young permanent teeth.…”

The Effect of Dental Paste With Herbal Content on Remineralization and The Imaging with Fluorescent Technique in Teeth with White Spot Lesion

“…Nowadays caries detection methods are able to measure the detected lesions quantitatively and evaluate as numerical data. Numerical evaluation of lesions parameters such as lesion area, lesion depth and mineral loss provides an objective examination (20).…”