Preventive effects of total flavonoids of Litsea coreana leve on hepatic steatosis in rats fed with high fat diet

Wang, Jianqing; Li, Jun; Zou, Yuhong; Cheng, Wenming; Lü, Chao; Zhang, Lei; Ge, Jin‐Fang; Huang, Cheng; Jin, Yong; Lv, Xiongwen; Hu, Chengmu; Liu, Liping

doi:10.1016/j.jep.2008.09.029

Cited by 59 publications

(39 citation statements)

References 36 publications

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“…Similarly, other studies have shown a decreased expression of FASN due to different flavonoids in HFD-fed animals (63,64). In addition, several other studies also describe flavonoids that inhibit FASN activity (65)(66)(67)(68)(69)(70)(71)(72). Specifically, Kweon et al (73) also found that the activity of FASN in rat liver was lowered by half by treatment with a grape seed extract.…”

Section: Discussionmentioning

confidence: 86%

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Baiges

Palmfeldt

Bladé

et al. 2010

Molecular & Cellular Proteomics

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Bioactive proanthocyanidins have been reported to have several beneficial effects on health in relation to metabolic syndrome, type 2 diabetes, and cardiovascular disease. We studied the effect of grape seed proanthocyanidin extract (GSPE) in rats fed a high fat diet (HFD). This is the first study of the effects of flavonoids on the liver proteome of rats suffering from metabolic syndrome. Three groups of rats were fed over a period of 13 weeks either a chow diet (control), an HFD, or a high fat diet supplemented for the last 10 days with GSPE (HFD ؉ GSPE). The liver proteome was fractionated, using a Triton X-114-based two-phase separation, into soluble and membrane protein fractions so that total proteome coverage was considerably improved. The data from isobaric tag for relative and absolute quantitation (

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Section: Discussionmentioning

confidence: 86%

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Baiges

Palmfeldt

Bladé

et al. 2010

Molecular & Cellular Proteomics

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“…While more studies are necessary to clarify the exact mechanism of action, we could hypothesize these effects to be related to phenolic compounds that are present in grape seed oil (21). Polyphenolic compounds that are structurally related to chalcone, including flavonoids (22) and coumarin chalcones (23) have been reported to improve lipid profile in high-fat fed or hyperlipidemic animals. Interestingly, the used compounds are also able to act directly on the adipose cells, which presented altered morphology in the treated animals, and chalcone itself seems to possess an independent effect (i.e, independent from grape seed oil).…”

Section: Discussionmentioning

confidence: 99%

Acarbose versus trans-chalcone: comparing the effect of two glycosidase inhibitors on obese mice

Jalalvand

Amoli

Yaghmaei

et al. 2015

Arch. Endocrinol. Metab.

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Objective: Acarbose and trans-chalcone are glucosidase inhibitors whose beneficial effects have been demonstrated in diabetes. The present study aimed at investigating their potential effects in obesity. Materials and methods: NMRI male mice (n = 48) were subjected to a high fat diet for four weeks, which induced an initial state of obesity. One control group was given normal rodent diet. Obese animals were then switched to normal rodent diet, and divided to four groups (n = 12 in each): untreated, sham (receiving grape seed oil), and experimental groups receiving acarbose and trans-chalcone (12 mg/kg) during eight weeks. Body weight, blood glucose and other biochemical parameters including triglycerides (TG), cholesterol, HDL, AST, and ALT were measured, as well as leptin, adiponectin, TNF-α, and total antioxidant capacity (TAC). Histological studies were performed on adipose cells and liver tissue samples. Results: All factors were affected in a positive manner by acarbose, save for body weight, blood sugar and leptin levels, on which acarbose effects, although observable, were not statistically significant. Grape seed oil, used as a solvent for trans-chalcone was found to possess significant effect on TG and TAC, and had beneficial effects on other factors including liver enzymes and cholesterol. Trans-chalcone effects were significant on HDL, leptin and ALT. All compounds seemed to be able to affect fat deposition in liver tissue, and decrease the size of adipose tissue cells to some extent. Conclusion: In conclusion, the tested compounds were able to affect lipid accumulation in tissues and influence adipokines, which may result in an enhanced state with regard to inflammation and oxidative stress. Arch Endocrinol Metab. 2015;59(3):202-9

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“…Previous phytochemical studies revealed the presence of alkaloids (Hart et al 1969;Bhakuni and Gupta, 1983;Holloway and Scheinmann, 1973), butanolides (Cheng et al 2001;Chen et al 1998), and sesquiterpenoids (Hoang et al 2002;Zhang et al 2001;Zhang et al 2003a;Zhang et al 2003b) in the genus Litsea. Few records are found in the literature with respect to the isolation of flavonoids from Litsea species (Wang et al 2009). Its bark and leaves are used as a demulcent and mild astringent for diarrhea and dysentery and the roots are used to poultice sprains and bruises (Wang et al 2010).…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and antinociceptive potentialities of methanolic extract of Litsea glutinosa

Rumzhum

Rahman

Sharukh

et al. 2013

Bangladesh J. Sci. Ind. Res.

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The methanolic extract of Litsea glutinosa (Lauraceae) was evaluated for in vitro antioxidant activity by determination of hydrogen peroxide scavenging activity, total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test and in vivo antinociceptive effect in acetic acid induced writhing model in swiss albino mice. The results revealed the presence of pronounced antioxidant property as compared with ascorbic acid used as standard and a dose-dependent (250 and 500 mg/kg) analgesic effect. The antioxidant and antinociceptive properties observed seem to be in good accordance with the traditional uses of Litsea glutinosa.

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Preventive effects of total flavonoids of Litsea coreana leve on hepatic steatosis in rats fed with high fat diet

Cited by 59 publications

References 36 publications

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Acarbose versus trans-chalcone: comparing the effect of two glycosidase inhibitors on obese mice

In vitro antioxidant and antinociceptive potentialities of methanolic extract of Litsea glutinosa

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