Preventive Efficiency of Green Tea and Its Components on Nonalcoholic Fatty Liver Disease

Zhou, Jie; Ho, Chi‐Tang; Long, Piaopiao; Meng, Qilu; Liang, Zhang; Wan, Xiaochun

doi:10.1021/acs.jafc.8b05032

Cited by 62 publications

(44 citation statements)

References 110 publications

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“…It is because tea contains plenty of pharmacologically active molecules that is why it has been used for various health benefits. For instance, these bioactive constituents in green tea were proved to alleviate the risk of nonalcoholic fatty liver disease (Zhou et al, 2019). Tea catechins pose beneficial effects in the prevention of carcinogenesis and cardiometabolic diseases, have been well documented (Yang & Zhang, 2019).…”

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confidence: 99%

Effects of tea consumption on metabolic syndrome: A systematic review and meta‐analysis of randomized clinical trials

Liu

Wan

Huang

et al. 2020

Phytotherapy Research

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The metabolic syndrome (MetS) is one of the major health hazards and an epidemic worldwide. There is no known best remedy has been defined yet. In the current investigation, we designed a meta-analysis of randomized clinical trials (RCTs) to evaluate the beneficial effects of tea consumption in alleviating metabolic syndromes. Herein, we accumulated the relevant literature available on PubMed and EMBASE databases from January, 2000 to August, 2019. RCTs bearing impact factor of at least 1 or more were studied for the effect of tea consumption on MetS. This metaanalysis suggested that tea consumption has beneficial effects on diastolic blood pressure (DBP), and this finding was characterized of all types of tea in the current study and also for body mass index (BMI) value. Furthermore, this analysis also found that black tea consumption has protective effects on systolic SBP, green tea reduces the incidence of diabetes and lower the level of low-density lipoprotein (LDL) cholesterol. These functions required BMI value at least 28 or higher. The meta data led us to conclude that tea consumption have protective effects on MetS, however, different types of tea might have different protective mechanisms on MetS, but, exact mechanisms are not yet clear and needs to be explored.

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confidence: 99%

Effects of tea consumption on metabolic syndrome: A systematic review and meta‐analysis of randomized clinical trials

Liu

Wan

Huang

et al. 2020

Phytotherapy Research

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“…In addition, we found a significant inverse association between total polyphenol intake and mortality from digestive disease. It was reported that coffee and green tea could exert such beneficial effects on liver and bowel diseases [39][40][41][42][43]. Further studies evaluating associations between polyphenol intake and digestive disease are awaited.…”

Section: Discussionmentioning

confidence: 99%

Dietary intake of total polyphenols and the risk of all-cause and specific-cause mortality in Japanese adults: the Takayama study

Taguchi

Kishimoto

Fukushima³

et al. 2019

Eur J Nutr

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Purpose Several epidemiological studies have demonstrated the health benefits of polyphenols, but the associations between polyphenol intake and mortality including total and major causes of death remain unclear. We investigated the associations between subjects' total polyphenol intake and their mortality from all causes, cardiovascular disease (CVD), cancer, and other causes of death in a population-based cohort study in Japan. Methods A total of 29,079 residents of Takayama City, Japan were analyzed. Their dietary intake was assessed using a validated semi-quantitative food-frequency questionnaire (FFQ) in 1992. Mortality was ascertained over the subsequent 16 years. The dietary polyphenol intake was calculated by matching the subjects' food consumption data with our original polyphenol content database. Results A total of 5339 deaths occurred during the follow-up. After multivariable adjustment, the highest quartile of total polyphenol intake compared with the lowest quartile was significantly associated with a lower risk of all-cause mortality (HR: 0.93, 95% CI: 0.82-0.99, p trend = 0.003). The subjects in the highest quartile showed significantly lower CVD mortality compared to those in the lowest quartile, and among the types of CVD mortality, a strong inverse association was observed for stroke mortality. Inverse associations were also observed for mortality from other causes, specifically digestive disease. The total polyphenol intake was not significantly associated with the risk of cancer mortality. Conclusions The results of this prospective study indicate that dietary total polyphenol intake in Japanese is inversely associated with all-cause mortality and mortality from cardiovascular and digestive diseases.

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“…Thus, the antioxidant capacity of EF-D seems to have an important connection with treating NAFLD. It has been reported that polyphenols through activation of Nrf2-ARE signal pathways respond to oxidative stress for inhibiting lipid accumulation [ 40 ]. Furthermore, Nrf2 promotes the activation of downstream relative target genes, such as HO-1, NQO1, CAT, and GSTA2, leading to improved oxidative stress resistance [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Amelioration by Idesia polycarpa Maxim. var. vestita Diels. of Oleic Acid-Induced Nonalcoholic Fatty Liver in HepG2 Cells through Antioxidant and Modulation of Lipid Metabolism

Sun

et al. 2020

Oxidative Medicine and Cellular Longevity

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Idesia polycarpa Maxim. var. vestita Diels (I. polycarpa) is well known as an edible oil plant which contains abundant linoleic acid and polyphenols. The objective of this study was to maximize the by-product of defatted fruit of I. polycarpa. We found that the fraction D of ethyl acetate extract (EF-D) contained more polyphenols, which contribute to its strong antioxidant activity by antioxidant assays (DPPH, ABTS, and FRAP). Meanwhile, EF-D showed a significant lipid-lowering effect on oleic acid- (OA-) induced hepatic steatosis in HepG2 cells through enhancing antioxidant activity, reducing liver damage, and regulating lipid metabolism, antioxidant, and inflammation-related gene expression. The SOD and T-AOC levels significantly increased, but the levels of MDA, AST, and ALT decreased obviously when treated with EF-D. In general, EF-D improved the antioxidant enzyme activities and decreased the hepatic injury activities. Besides, treatment with EF-D for NAFLD influenced lipid metabolism and inflammation by activating PPARα which was associated with the increased expression of CPT1 and decreased expression of SCD, NF-κB, and IL-1. Moreover, EF-D improved the oxidative stress system through activation of the Nrf2 antioxidant signal pathways and upregulated its target genes of HO-1, NQO1, and GSTA2. The results highlighted the EF-D from the defatted fruit of I. polycarpa regarding lipid-lowering, proving it to be a potential drug resource of natural products for treating the nonalcoholic fatty liver disease (NAFLD).

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Preventive Efficiency of Green Tea and Its Components on Nonalcoholic Fatty Liver Disease

Cited by 62 publications

References 110 publications

Effects of tea consumption on metabolic syndrome: A systematic review and meta‐analysis of randomized clinical trials

Effects of tea consumption on metabolic syndrome: A systematic review and meta‐analysis of randomized clinical trials

Dietary intake of total polyphenols and the risk of all-cause and specific-cause mortality in Japanese adults: the Takayama study

Amelioration by Idesia polycarpa Maxim. var. vestita Diels. of Oleic Acid-Induced Nonalcoholic Fatty Liver in HepG2 Cells through Antioxidant and Modulation of Lipid Metabolism

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