Preventive management of hypoglycemia in very low‐birthweight infants following indomethacin therapy for patent ductus arteriosus

Abstract

This retrospective study shows that an increase in glucose infusion rate of 2 mg/kg per min, in addition to the pre-existing stable maintenance glucose intake, might prevent against the occurrence of unexpected hypoglycemia in VLBW infants following indomethacin therapy.

Hypoglycaemia in an infant with severe pulmonary hypertension after prenatal exposure to nimesulide: coincidence or side effect?

“…In neonates, indomethacin has been invariably reported to cause a decrease in blood glucose levels when used for closure of patent ductus arteriosus in preterm babies, and increased glucose intake and hydrocortisone treatment have been necessary to resolve hypoglycaemia in these infants (4). Moreover, in a retrospective study, Hosono et al showed that an increase in glucose infusion rate might prevent the occurrence of hypoglycaemia in preterm infants following indomethacin therapy (5).…”