Primary Adenocarcinoma of the Frontal Sinus

Wadhera, Raman; Gulati, S. P.; Garg, Ajay; Ghai, Anju; Kumar, Sanjay

doi:10.1177/014556131109001022

Cited by 7 publications

(10 citation statements)

References 6 publications

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“…By this scheme, stage I tumors are limited to the site of origin; stage II tumors demonstrate extension to adjacent sites, such as the orbit, paranasal sinuses, skin, nasopharynx, and pterygomaxillary fossa; and stage III tumors demonstrate base of skull or pterygoid plate destruction and/or intracranial extension. 11,21,23 Most patients will have stage II or stage III disease at presentation. Tumor involvement of the skin overlying the anterior nasal vault and/or extension into the anterior nasal mucosa is often seen when metastases are observed in these patients.…”

Section: Discussionmentioning

confidence: 99%

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Frontal Sinus Malignancies

Bhojwani

Unsal

Dubal

et al. 2015

Otolaryngol.--head neck surg.

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Section: Discussionmentioning

confidence: 99%

“…1 Although the pathogenesis of malignant tumors specific to the frontal sinus has not been well studied, exogenous risk factors for paranasal sinus malignancies identified have included wood dust exposure and industrial processes such as chromium, nickel, and mustard gas production. 4,5,8,10-12…”

mentioning

confidence: 99%

Frontal Sinus Malignancies

Bhojwani

Unsal

Dubal

et al. 2015

Otolaryngol.--head neck surg.

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“…Articles not meeting the inclusion criteria were excluded. Further exclusion criteria were: case reports without significant outcome data, reports on surgical debulking, and studies regarding local 5‐fluorouracil applications . To further reduce the risk of an incomplete literature search, a manual search through the references of the included articles was performed.…”

Section: Methodsmentioning

confidence: 99%

Endoscopic nasal versus open approach for the management of sinonasal adenocarcinoma: A pooled‐analysis of 1826 patients

et al. 2015

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Background. Surgical resection represents the gold standard for the treatment of sinonasal malignancies. This study reviewed the published outcomes on endoscopic surgery or endoscopic-assisted surgery versus open approach for the management of sinonasal adenocarcinomas. Methods. PubMed, EMBASE, the Cochrane Library, and CENTRAL electronic databases were searched for English language articles on endoscopic surgery, endoscopic-assisted surgery, and open approach for sinonasal adenocarcinomas. Each article was examined for patient data and outcomes for analysis. Results. Thirty-nine articles including 1826 patients were used for the analysis. The endoscopic surgery and endoscopic-assisted surgery showed low rates of major complications (6.6% and 25.9%, respectively) compared to open approaches (36.4%; p < .01). The incidence of local failure was lower in the endoscopic surgery group as compared with open approach patients (17.8% vs 38.5%; p < .01, respectively). The multivariate Cox regression model showed a worst overall survival related to advanced T classification and open approach. Conclusion. From the existing body of data, there is growing evidence that endoscopic nasal resection is a safe surgical option in the management of sinonasal adenocarcinomas.

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“…However, the speci c pattern and frequency of tumor invasion has not been su ciently explored in FSMs. On the other hand, the extensive invasion of lesions makes it di cult to achieve complete resection with negative margins for FSMs, which often leads to high local failure rates of 31%-60% [4][5][6][7][8][9][10][11][12][13][14][15]. Given disease rarity, histological diversity, late presentation, invasion of neighboring structures, seldom obtained negative margins, primary frontal sinus malignancies presented enormous challenges to physicians.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and long-term outcomes following surgery combined with adjuvant radiotherapy for primary frontal sinus malignancies: A single-center analysis

Wang

Zhang

et al. 2021

Preprint

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Objective This study aimed to determine clinicopathologic characteristics of primary frontal sinus malignancies (FSMs) and provide long-term survival results. Materials and methods A retrospective study of six cases of primary FSMs at our center from 2006 to 2016 was performed. The demographics characteristics, tumor characteristics, treatment modalities and survival outcomes were recorded. Results In this series, the median age was 48 years (30–53 years) and all patients were male. There were five cases with squamous cell carcinoma, and one with osteosarcoma. All cases presented with locally advanced disease without regional lymphatic metastasis, including 5 cases of stage Ⅲ and one of stage Ⅱ. The two most common pathways of tumor invasion were as follows: local tumor broke posteriorly through bone wall and invaded dura mater, followed by frontal lobe; local tumor infiltrated downward through the floor of frontal sinus into ethmoid sinus, thereafter invaded laterally orbit and orbital contents. All patients received surgery followed by postoperative radiotherapy at the total doses of 50Gy to 75.95Gy. Among them, only one patient underwent R0 resection, the rest of patients underwent R1/R2 resection. With a median survival time of 56 months (32 to 76 months), two patients receiving R1/R2 resection developed treatment failure and died within 5 years, including one case with local recurrence, and one with local recurrence thereafter distant metastasis. Conclusion The majority of FSMs presented with peripherally invasive progression lesions, which led to a high ratio of R1/R2 resection. Surgery combined with postoperative radiotherapy might result in satisfactory efficacy.

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Primary Adenocarcinoma of the Frontal Sinus

Cited by 7 publications

References 6 publications

Frontal Sinus Malignancies

Frontal Sinus Malignancies

Endoscopic nasal versus open approach for the management of sinonasal adenocarcinoma: A pooled‐analysis of 1826 patients

Clinical characteristics and long-term outcomes following surgery combined with adjuvant radiotherapy for primary frontal sinus malignancies: A single-center analysis

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