Primary Adenocarcinoma of the Urinary Bladder

Kapur, Payal; Lotan, Yair; King, Ellen S; Kabbani, Wareef; Mitra, Anirban P.; Mosbah, Ahmed; Abol‐Enein, Hassan; Ghoneim, Mohamed A.; Youssef, Ramy

doi:10.1309/ajcp76kuvotbkqry

Cited by 22 publications

(20 citation statements)

References 28 publications

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“…On histopathology it shows only increase in thickness of epithelium, but the cells does not exhibit cytologic atypia; feature also seen in papilloma. (13,14,15) During cystoscopy, PUNLMP lesions are less than 2 cm with papillary projections. Histopathologically, they show more than seven layer thick urothelium with cells without any cytological atypia.…”

Section: Discussionmentioning

confidence: 99%

A Clinicopathological Study of Various Lesions Encountered in Cystoscopic Bladder Biopsies

Khochikar¹,

P²,

Mote³

et al. 2016

jemds

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BACKGROUNDIn clinical practice tumours of the bladder are one of the most common urological lesions observed and it is the 7 th most common cancer worldwide. Urinary bladder malignancies accounts for 3.2% of all cancers worldwide and males are commonly affected than females. Non-neoplastic lesions like chronic non-specific cystitis is most commonly seen and is important source of clinical signs and symptoms. Aim of the present study was to analyse the histopathological findings of different lesions in cystoscopic biopsies and to study the frequency of different pathological lesions with respect to age, sex, clinical symptoms, etc.

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Section: Discussionmentioning

confidence: 99%

A Clinicopathological Study of Various Lesions Encountered in Cystoscopic Bladder Biopsies

Khochikar¹,

P²,

Mote³

et al. 2016

jemds

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“…Ki-67 is the most used proliferative marker, and it has been helpful for diagnosis, and determination of aggressiveness and prognosis of many cancers (3)(4)(5)(6)(7)(8)(9)(10)(11). In CXPA, Ki-67 index can provide more objective criteria to distinguish atypical cells without malignant potential from the carcinomatous foci.…”

Section: Introductionmentioning

confidence: 99%

Cellular Proliferation Index between Carcinoma Ex-Pleomorphic Adenoma and Pleomorphic Adenoma

et al. 2015

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Carcinoma ex pleomorphic adenoma (CXPA) has been considered an interesting model of carcinogenesis, presenting various histological subtypes and invasiveness phase. The objective was to determine the proliferative index of CXPA and comparing to pleomorphic adenoma (PA). Thirty six cases of CXPA (36 PA) and 22 areas of PA in CXPA (residual PA) were studied by Ki-67 expression. All CXPA cases were classified according to invasiveness phase (intracapsular, minimally and frankly invasive) and histopathological subtypes. Data was statistically analyzed by Wilcoxon, Mann-Whitney and Kruskal-Wallis tests. CXPA included 5 intracapsular, 9 minimally invasive and 22 frankly invasive cases. Fifteen cases corresponded to salivary duct carcinoma, 7 to adenocarcinoma NOS, 7 myoepithelial, 5 epithelial-myoepithelial, one case of squamous cell and one case of sarcomatoid carcinoma. The Ki-67 index of PA and residual PA were significantly lower than CXPA. Intracapsular and minimally invasive showed smaller proliferative index than frankly invasive. Considering the subtypes of CXPA, there was not a statistic difference among them. Ki-67 is a useful marker in the differential diagnosis of PA and CXPA, even when in the early invasive phase.

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“…Cyclin E expression and, consequently, cyclin E/CDK2 activity is closely associated with the G1/S checkpoint (12). Various studies have indicated that cyclin E is overexpressed in several tumor cells, such as breast cancer cells, and it has been reported to be a prognostic biomarker (13,14). p27…”

Section: Introductionmentioning

confidence: 99%

Glucosamine, a naturally occurring amino monosaccharide, inhibits A549 and H446 cell proliferation by blocking G1/S transition

Sun

et al. 2013

Molecular Medicine Reports

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Abstract. Uncontrolled proliferation is important in tumorigenesis. In the present study, the effects of glucosamine on lung cancer cell proliferation were investigated. The expression of cyclin E, one of the key cyclins in the G1/S transition, and Skp2, the ubiquitin ligase subunit that targets the negative cell cycle regulator, p27 Kip1, were also assessed. Moreover, the underlying mechanisms of action of glucosamine were investigated in lung cancer cells. A549 and H446 cells were synchronized using thymidine in the presence or absence of glucosamine. The effect of glucosamine on lung cancer cell proliferation was determined by MTT assay. Cyclin E and p27Kip1 proteins and their phosphorylation levels were detected by western blot analysis. Furthermore, the effect of glucosamine on the cell cycle was evaluated by flow cytometry. Glucosamine was found to inhibit lung cancer cell proliferation and to suppress Skp2 and cyclin E expression. Notably, the phosphorylation levels of cyclin E (Thr62) and p27 Kip1 (Thr187) were downregulated by glucosamine, and negatively correlated with degradation. Glucosamine was also found to arrest lung cancer cells in the G1/S phase. Thus, glucosamine may inhibit lung cancer cell proliferation by blocking G1/S transition through the inhibition of cyclin E and Skp2 protein expression.

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Primary Adenocarcinoma of the Urinary Bladder

Cited by 22 publications

References 28 publications

A Clinicopathological Study of Various Lesions Encountered in Cystoscopic Bladder Biopsies

A Clinicopathological Study of Various Lesions Encountered in Cystoscopic Bladder Biopsies

Cellular Proliferation Index between Carcinoma Ex-Pleomorphic Adenoma and Pleomorphic Adenoma

Glucosamine, a naturally occurring amino monosaccharide, inhibits A549 and H446 cell proliferation by blocking G1/S transition

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