Primary adult intratesticular rhabdomyosarcoma: Results of the treatment of six cases

Abstract

Abstract:The aim of the present study was to assess the treatment outcomes in a cohort of adult patients with intratesticular rhabdomyosarcoma. Between 1999 and 2008, 296 patients underwent radical orchiectomy for intrascrotal mass. A retrospective chart review was carried out for adult patients diagnosed with intratesticular rhabdomyosarcoma. Overall, six patients (mean age 21 years, range 17-23) were included: five had embryonic rhabdomyosarcoma and one had pleomorphic rhabdomyosarcoma. Four patients underwent retroperitoneal lymph node dissection and five patients had postoperative chemotherapy. The mean length of follow up was 28 months (range 12-51 months). One patient was lost to follow up after 26 months, five cases remained alive at the end of the study. Surgical resection with chemotherapy was an effective way to achieve favorable outcomes and long-term survival in adult patients with metastases from intratesticular rhabdomyosarcoma.

Primary intratesticular rhabdomyosarcoma: A case report and literature review

“…Widespread metastasis of the mass was detected by 18 F-fluorodeoxyglucose-positron emission tomography-computed tomography (FDG-PET-CT) 3 weeks after the RIO. According to our limited knowledge, the use of FDG-PET-CT has been reported only once previously to determine a clinical stage and evaluate the treatment efficacy of ITRMS (2). The ITRMS described in the present case underwent distant metastasis within a shorter time period than those cases reported in the literature (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

“…Chemotherapy is generally effective in treating RMS, and the recommended chemotherapy regimen for the treatment of IRSG is VAC, consisting of vincristine, actinomycin D and cyclophosphamide (9). In the present literature review, 6 cases chose the VAC regimen and 4 cases chose the VA regimen (2,6,8,10,11). Numerous chemotherapeutic agents have been tested in clinical trials.…”

“…RIO, as an initial treatment of ITRMS, is mandatory for all patients, and may therefore serve an important role in the pathological diagnosis and treatment of the disease. RIO, followed by chemotherapy, appears to be the optimal treatment for ITRMS (2). Chemotherapy is generally effective in treating RMS, and the recommended chemotherapy regimen for the treatment of IRSG is VAC, consisting of vincristine, actinomycin D and cyclophosphamide (9).…”

“…CR was observed in 50% (6/12) of cases, PR in 33.3% (4/12) of cases and disease progression in 16.7% (2/12) of cases. Retroperitoneal lymph node dissection (RPLND) was performed in 3 patients presenting with RPLN metastasis and in 4 patients without evidence of metastasis for staging (2,11). The median duration of follow-up of the 17 cases with data was 22 months (range, 3-96 months), including 1 patient who was lost to follow-up 26 months after RIO, and 2 patients who succumbed at 18 and 20 months, respectively, following RIO, who presented with distant metastasis.…”

“…According to our limited knowledge, the use of FDG-PET-CT has been reported only once previously to determine a clinical stage and evaluate the treatment efficacy of ITRMS (2). The ITRMS described in the present case underwent distant metastasis within a shorter time period than those cases reported in the literature (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). In order to improve our understanding regarding the clinic characteristics of ITRMS, the current study presents a notable case and reviews the available literature of primary ITRMS from the 1960s onwards (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”