Primary and secondary prevention of colorectal cancer in the Czech Republic

Azeem, Kateřina; Ševčíková, Jarmila; Kyselý, Zdeněk; Horáková, D; Vlčková, Jana; Kollárová, Helena

doi:10.5114/pg.2016.57819

Cited by 5 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the Czech Republic, a European country with CRC incidence among the highest worldwide, only 25% of individuals eligible for screening undergo regular screening: ∼500 000 immunologic fecal occult blood tests (IFBTs) a year 2. However, in a study that included 50 primary healthcare centers in Serbia, 50 894 individuals were invited to participate in a CRC screening program using IFBT.…”

Section: Participation Rates Of Colorectal Cancer Screening Programsmentioning

confidence: 99%

Screening for colorectal cancer: the role of the primary care physician

Triantafillidis

Vagianos

Gikas³

et al. 2017

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

In recent years, the role of primary care physicians (PCPs) in the diagnosis and management of gastrointestinal disorders, including screening for colorectal cancer (CRC), has been recognized as very important. The available data indicate that PCPs are not adequately following CRC screening guidelines because a number of factors have been identified as significant barriers to the proper application of CRC screening guidelines. These factors include lack of time, patient reluctance, and challenges related to scheduling colonoscopy. Further positive engagement of PCPs with CRC screening is required to overcome these barriers and reach acceptable levels in screening rates. To meet the expectations of modern medicine, PCPs should not only be able to recommend occult blood testing or colonoscopy but also, under certain conditions, able to perform colonoscopy. In this review, the authors aim to provide the current knowledge of the role of PCPs in increasing the rate and successfully implementing a screening program for CRC by applying the relevant international guidelines.

show abstract

Section: Participation Rates Of Colorectal Cancer Screening Programsmentioning

confidence: 99%

Screening for colorectal cancer: the role of the primary care physician

Triantafillidis

Vagianos

Gikas³

et al. 2017

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

show abstract

“…In contrast with consistent result which con rmed an inverse association between physical activity and colon cancer risk [9,23,31,[96][97][98][99][100][101][102][103][104][105][106][107], results from the studies that examined the association between physical activity and rectal cancer risk are inconsistent [6,22,23,74,76,78,96,97,103,108,109]. However, Colinda C. J. M. Simons et al, in a casecontrol study carried out on 120 000 subjects in Netherland found that regular participation in recreational physical activity such as daily walking and riding bicycle reduced rectal cancer risk among women but not among men [110].…”

Section: Colorectal Cancermentioning

confidence: 62%

Physical Activity and Gastrointestinal Cancer Risk: A Review

Tajabadi

Akbari

Hafez

2019

Acta Medica Bulgarica

View full text Add to dashboard Cite

Introduction: Western lifestyle characterized by increased consumption of red meat, fat, processed food, smoking, alcohol drinking, lower consumption of vegetables and physical inactivity has been associated with a higher gastrointestinal cancer risk. Digestive system cancers are diagnosed at late stages when they show poor response to treatment and are associated with a high mortality rate. Colorectal, gastric, esophageal and pancreatic cancers are among the most common cancers worldwide. Studies show that more than 50% of gastrointestinal cancers develop as a result of inappropriate lifestyle. An inverse association between physical activity and many chronic diseases has been proved so far. However, the association between physical activity and some gastrointestinal cancers is still controversial. This study was aimed to determine the association between physical activity and gastrointestinal cancers risk. Methods: We conducted a comprehensive search of English and Persian databases from February 2007 till December 2017, for studies investigating the association of physical activity and risk of gastrointestinal cancers. Finally, after reading full text of articles, 123 studies were included. Results: Physical activity can be helpful in reducing the risk of gastrointestinal cancer, especially colon and pancreatic cancers. The risk reduction is not similar for different types of gastrointestinal cancers and also among males and females. Conclusion: Different types of physical activity are associated with a lower risk of gastrointestinal cancer. However, it is unknown which type and intensity of physical activity are associated with a protective effect against gastro-intestinal cancer.

show abstract

“…A limitation of our study is the absence of sufficient dietary data in both the cohorts (none in the Irish and substantial missing and/or rudimentary data in the Czechs). However, Irish and Czech populations present similar dietary and lifestyle patterns, rich in processed and red meat, lacking in fruit and vegetable intake, and high smoking and alcohol consumption rates [45,46]. Furthermore, the incidence of excess weight and obesity is constantly growing in both countries [47,48].…”

Section: Discussionmentioning

confidence: 99%

Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer

Genua

Mirković

Mullee

et al. 2021

Clinical Nutrition ESPEN

View full text Add to dashboard Cite

Background & aims: Short chain fatty acid (SCFAs) are bacterially derived metabolites suggested to have protective roles against colorectal cancer (CRC) development. However, there is sparse evidence from epidemiological studies in this context. Here, we assessed whether circulating SCFA concentrations varied in patients with colorectal adenomas (CRA) and CRC. Methods: Levels of seven SCFAs were extracted from plasma samples and determined by gas chromatography for 213 individuals from Ireland and the Czech Republic (CRC, n ¼ 84; CRA, n ¼ 66; controls, n ¼ 63). Results: In the Irish CRA/CRC cohort, only levels of 2-MethylButyric acid were significantly higher in cancers compared to the adenoma and control groups (p-values ¼ 0.016 and 0.043). Using regression analysis, we observed that levels of Acetic and Propionic acid were associated with an increased CRC risk in the Czech cohort (Odd Ratio (OR): 1.02; 95% Confidence interval (CI): 1.00e1.03; OR: 1.29; 95% CI: 1.05 e1.59, respectively), while i-Valeric and Valeric acid levels were associated with a decreased cancer risk (OR: 0.92; 95% CI: 0.86e0.99; OR: 0.67; 95% CI: 0.44e1.00). In the Irish cohort, levels of SCFAs were not associated with CRC risk. Conclusions: The association with colorectal neoplasia varied between the studied SCFAs. Future studies need to confirm these findings and address the mechanism of how these acids may promote or prevent colorectal carcinogenesis.

show abstract

Primary and secondary prevention of colorectal cancer in the Czech Republic

Cited by 5 publications

References 27 publications

Screening for colorectal cancer: the role of the primary care physician

Screening for colorectal cancer: the role of the primary care physician

Physical Activity and Gastrointestinal Cancer Risk: A Review

Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer

Contact Info

Product

Resources

About