2009
DOI: 10.1590/s0036-46652009000100009
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Primary aspergilloma and subacute invasive aspergillosis in two AIDS patients

Abstract: SUMMARYAlthough uncommon, invasive aspergillosis in the setting of AIDS is important because of its peculiar clinical presentation and high lethality. This report examines two AIDS patients with a history of severe cellular immunosuppression and previous neutropenia, who developed subacute invasive aspergillosis. One female patient developed primary lung aspergilloma, with dissemination to the mediastinum, vertebrae, and spine, which was fatal despite antifungal treatment. The second patient, who had multiple … Show more

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Cited by 17 publications
(7 citation statements)
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“…Atypically, the patient had slight neutrophil leukocytosis and not neutropenia (Cornet et al, 2002). Elevated neutrophil counts were previously reported in a 33-year-old woman with AIDS who had disseminated aspergillosis affecting the brain and spine (Martinez et al, 2009). Furthermore, HIV-infected patients have defects in neutrophil function as well as activation of neutrophils, contributing to this dysfunction, which may manifest at all stages of HIV disease (Kuritzkes, 2000).…”
Section: Discussionmentioning
confidence: 79%
“…Atypically, the patient had slight neutrophil leukocytosis and not neutropenia (Cornet et al, 2002). Elevated neutrophil counts were previously reported in a 33-year-old woman with AIDS who had disseminated aspergillosis affecting the brain and spine (Martinez et al, 2009). Furthermore, HIV-infected patients have defects in neutrophil function as well as activation of neutrophils, contributing to this dysfunction, which may manifest at all stages of HIV disease (Kuritzkes, 2000).…”
Section: Discussionmentioning
confidence: 79%
“…[10] Risk factors for developing this rare CNS infection are recipients of immunosuppressive disorders such as HIV/AIDS, solid organ transplants, patients on chemotherapy, diabetes, heroin abuse, long-term steroid or broad-spectrum antibiotics use, neutropenia, history of opportunistic infection, and use of ganciclovir/valacyclovir. [12345678]…”
Section: Discussionmentioning
confidence: 99%
“…[1234] Here, we report a case of cerebrospinal fluid (CSF) culture-proven CNS aspergillosis in a middle-aged male with human immunodeficiency virus (HIV) positive illness who presented with febrile encephalopathy, seizures, and pancytopenia with normal contrast-enhanced computerized tomography (CECT) scan brain and normal initial CSF studies. High index of suspicion is necessary in considering fungal infections as a cause of meningoencephalitis; early diagnosis and initiation of potent antifungal may reduce the morbidity and mortality associated with this condition.…”
Section: Introductionmentioning
confidence: 99%
“…Las serologías para toxoplasmosis y enfermedad de Chagas fueron no reactivas. El recuento de linfocitos T CD4 era de 8 céls/mm 3 .…”
Section: Caso Clínicounclassified
“…Su incidencia varía entre distintos centros y según el tipo de inmunosupresión. En pacientes con síndrome de inmunodeficiencia adquirida (SIDA) su frecuencia es baja, variando entre 0 y 12% según diversos autores [1][2][3] . El órgano principalmente comprometido es el pulmón.…”
unclassified