Primary Bilateral High-Grade Vesicoureteral Reflux in Children: Management Perspective

Qahtani, Wadha Al; Sarhan, Osama; Otay, Abdulhakim Al; Helaly, Ahmed El; Kawai, Fouad Al

doi:10.7759/cureus.12266

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…Although similar findings have been reported [9,10], some studies have reported either no sex bias or female predominance [8,11]. In this study, VUR demonstrated bilaterality in 43% of patients, compared with 28% for both isolated right-and left-sided VUR, which is consistent with the findings of studies conducted in Nepal, Sudan, Saudi Arabia, and Brazil (60%, 56%, 61%, and 54%, respectively) [10][11][12][13]. Most cases had severe VUR of grades 4 and 5 (68%), followed by mild (grades 1 and 2, 50%) and moderate (grade 3, 25%) VUR.…”

Section: Discussionsupporting

confidence: 90%

Relationship Between Vesicoureteric Reflux and Nephrocalcinosis in Children: A Case-Control Study at a Tertiary Medical Center in Saudi Arabia

Al-Zahrani¹,

Al-Faraj²,

Llaguno³

et al. 2022

Cureus

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Background: Vesicoureteral reflux (VUR), one of the most common pediatric congenital urogenital abnormalities, refers to the abnormal backflow of urine from the urinary bladder back into the ureter or to the kidney. This causes urinary tract infections. Nephrocalcinosis (NC) refers to abnormal deposits of calcium within the renal parenchyma and/or in the renal cortex. Patients with NC are mostly asymptomatic and severe disease may progress to renal failure. Early diagnosis through examinations such as radiography, computed tomography, and ultrasonography, is crucial for therapeutic treatment. Ultrasonography is the preferred method for scanning and grading nephrocalcinosis in children, primarily because it emits no radiation. This study aimed to increase the body of knowledge regarding VUR and nephrocalcinosis by determining its prevalence and assessing the relationship between VUR and nephrocalcinosis in children presenting at our institution.Methods: A case-control study was conducted using data from the medical records of 632 children younger than 14 years in a tertiary medical center in Riyadh, Saudi Arabia. Eligible participants were assigned to two groups: Group 1 consisted of 316 patients with VUR, while Group 2 consisted of 316 sex-and age-matched patients without VUR. The difference in the prevalence of nephrocalcinosis between the two groups was assessed. Frequency and percentage were used to present the categorical variables; Pearson productmoment correlation was utilized to establish the association between VUR and nephrocalcinosis. Statistical significance was established at p<0.05.Result: Only two cases in Group 1 were positive for nephrocalcinosis (0.63%, one male and one female), while four cases in Group 2 were positive for the condition (1.26%, two males and two females). There was no significant difference in the incidence of nephrocalcinosis between the two groups (p=0.873), indicating no relationship between VUR and nephrocalcinosis in children. Conclusion:There is no relationship between VUR and nephrocalcinosis in children under the age of 14 years.

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Section: Discussionsupporting

confidence: 90%

Relationship Between Vesicoureteric Reflux and Nephrocalcinosis in Children: A Case-Control Study at a Tertiary Medical Center in Saudi Arabia

Al-Zahrani¹,

Al-Faraj²,

Llaguno³

et al. 2022

Cureus

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show abstract

“…Second VUR is classified into unilateral or bilateral according to the affected side. 16 Bilateral VUR is often associated with secondary reflux, such as neurogenic bladder or posterior urethral valves. Previous studies have focused on unilateral VUR grading and the grading of bilateral reflux requires manually split sides.…”

Section: Discussionmentioning

confidence: 99%

Development and multi-institutional validation of a deep learning model for grading of vesicoureteral reflux on voiding cystourethrogram: a retrospective multicenter study

Li,

Tan,

Wang

et al. 2024

eClinicalMedicine

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“…The incidence of bilateral VUR ranges from 30% to 58% of all children. Furthermore, VUR is one of the remarkable causes of the chronic kidney disease (CKD) in children (1). Metaplastic changes are frequently observed in the histologic microscopic evaluation, which are in relation to the inflammatory stimuli, due to the infections or calculi (2).…”

Section: Introductionmentioning

confidence: 99%

Transitional Metaplasia of Renal Collecting Ducts in Vesicoureteral Reflux and Chronic Pyelonephritis: An Immunohistochemical Study of a Case and Review of the Literature

Tayyebi Meibodi,

Soltani,

Torabian

2023

Iran J Pathol

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Primary Bilateral High-Grade Vesicoureteral Reflux in Children: Management Perspective

Cited by 6 publications

References 30 publications

Relationship Between Vesicoureteric Reflux and Nephrocalcinosis in Children: A Case-Control Study at a Tertiary Medical Center in Saudi Arabia

Relationship Between Vesicoureteric Reflux and Nephrocalcinosis in Children: A Case-Control Study at a Tertiary Medical Center in Saudi Arabia

Development and multi-institutional validation of a deep learning model for grading of vesicoureteral reflux on voiding cystourethrogram: a retrospective multicenter study

Transitional Metaplasia of Renal Collecting Ducts in Vesicoureteral Reflux and Chronic Pyelonephritis: An Immunohistochemical Study of a Case and Review of the Literature

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