Primary bilateral ovarian and uterine Burkitt’s lymphoma following chemotherapy for breast cancer

PurposeThis review presents the information about epidemiology, clinical manifestation, diagnosis and treatment of primary ovarian Burkitt’s lymphoma (BL), including a literature search of available BL cases. The purpose of this review is to draw clinicians’ attention to the possibility of ovarian BL occurrence, which may be important in the differential diagnosis of ovarian tumours.MethodsPubMed and Web of Science databases were searched using the keywords ‘‘Burkitt’s’’, ‘‘Lymphoma’’, ‘‘Ovarian’’, ‘‘Primary’’, ‘‘Burkitt’s lymphoma’’. Only cases with histopathologically confirmed diagnosis of primary ovarian BL were included in this review.ResultsFifty articles, reporting cases with an ovarian manifestation of primary non-Hodgkin’s lymphoma, were found. Twenty-one cases with a histopathologically confirmed BL were evaluated to compare various manifestations, treatment and prognosis in ovarian BL.ConclusionsPrimary ovarian BL is a rare condition, included in the entity of non-Hodgkin lymphoma. The tumour can occur uni- or bilaterally in the ovaries with major symptoms such as abdominal pain or a large abdominal mass. Differential diagnosis, based on imaging features and pathological examination of the specimens, is essential for further treatment due to various aetiology of ovarian tumours. Although most of the patients suffering from ovarian BL underwent surgery after the ovarian tumour had been detected, surgical treatment is not the treatment of choice in patients with ovarian lymphoma. The mainstay of therapy is chemotherapy without further surgery. The prognosis is better if the chemotherapy protocol is more aggressive and followed by prophylactic central nervous system chemotherapy. Nowadays, multiagent protocols are administered, which improves the survival rate.

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“…MYC gene rearrangements are typical for BL [ 21 ], but according to the WHO these translocations are not obligatory to diagnose BL [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…The prognosis is better if the chemotherapy protocol is more aggressive and followed by prophylactic central nervous system chemotherapy. Nowadays, multiagent protocols are administered, which improves the survival rate [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Primary ovarian Burkitt’s lymphoma: a rare oncological problem in gynaecology: a review of literature

Stępniak

Czuczwar

Szkodziak

et al. 2017

Arch Gynecol Obstet

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“…Until present, there have been a considerable number of case reports describing uterine involved NHL. A Medline search resulted in nine case reports describing total of 10 cases of primary uterine lymphoma within the past 5 years [5][6][7][8][9][10][11][12][13]. A summary is shown in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Non-Hodgkin’s Lymphoma Involving the Uterus

Nakayama¹

2014

Gynecol Obstet (sunnyvale)

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Diagnosis of uterine lymphoma is challenging due to its rarity and non-specific presentation. Treatment is also difficult since there is no standard treatment. We report our experience with two cases of lymphoma involving the uterus. The first patient was a 66-year-old with chief complaint of lower abdominal pain. She was diagnosed as lymphoma of the uterus by laparotomy. Chemotherapy failed and she died in the course of a year. The second patient was a 63-year-old who presented with general fatigue. Tissue biopsy and CT scan revealed lymphoma of the stomach with multiple metastases including the uterus. She was treated with chemotherapy followed by radiation therapy, but died 18 months later. Lymphoma involving the uterus is rare and diagnosis can be difficult. Clinicians should be aware of this rare disease for prompt diagnosis. Treatment should be individualized according to the condition of each patient.

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“…ovary and uterine body). Other authors [2,10] consider Ann Arbor stage I E (E = involvement of extra-lymphatic organs, l " Table 1) to be sufficient for the diagnosis of primary lymphoma, while other authors completely dispense with giving their criteria [4][5][6][7]9]. Even if the case described here did not comply with No.…”

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confidence: 97%

“…As lymphatic tissue is normally not present in the ovary, primary malignant lymphomas of the ovary are rare. They constitute less than 1% of all malignant lymphomas and the literature on primary malignant ovarian lymphomas consists only of case reports or small series [4][5][6][7][8][9][10]. Some authors have proposed criteria which could be used to differentiate between secondary and primary malignant lymphomas [1][2][3]10], and these criteria will be discussed below.…”

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confidence: 99%

Primary Burkittʼs Lymphoma of the Ovary in Early Weeks of Pregnancy – A Case Report

Steininger

Gruden

Müller

2012

Geburtsh Frauenheilk

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Primary bilateral ovarian and uterine Burkitt’s lymphoma following chemotherapy for breast cancer

Abstract: Burkitt's lymphoma arising from the uterus/cervix is extremely rare and may present as a pelvic mass. Early diagnosis, aggressive chemotherapy, +/-surgical intervention, plays an important role in management and survival of patients with Burkitt's lymphoma.

Cited by 8 publications

References 27 publications

Primary ovarian Burkitt’s lymphoma: a rare oncological problem in gynaecology: a review of literature

Primary ovarian Burkitt’s lymphoma: a rare oncological problem in gynaecology: a review of literature

Two Cases of Non-Hodgkin’s Lymphoma Involving the Uterus

Primary Burkittʼs Lymphoma of the Ovary in Early Weeks of Pregnancy – A Case Report

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