Primary bone neoplasms in dogs: 90 cases

Trost, María Elisa; Kommers, Gláucia D.; Brown, Corrie C.; Barros, Claudio S.L.; Irigoyen, Luiz Francisco; Fighera, Rafael A.; Inkelmann, Maria Andréia; Silva, Taiara M. da

doi:10.1590/s0100-736x2012001200018

Cited by 18 publications

(25 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These are aggressive tumors that may cause local bone destruction, invade the adjacent soft tissues, and have a high metastatic potential. The lungs are the main organ affected by metastasis of osteosarcoma, and metastasis to the CNS are not common (Trost et al 2012). In a previous study that evaluated 43 osteosarcomas in dogs submitted to necropsy, only one case presented a CNS metastasis (Trost et al 2012), which is similar to the present study, where only two cases of 78 had osteosarcoma metastasis.…”

Section: Discussionsupporting

confidence: 88%

“…The lungs are the main organ affected by metastasis of osteosarcoma, and metastasis to the CNS are not common (Trost et al 2012). In a previous study that evaluated 43 osteosarcomas in dogs submitted to necropsy, only one case presented a CNS metastasis (Trost et al 2012), which is similar to the present study, where only two cases of 78 had osteosarcoma metastasis. In both cases, these were focal and had the same distribution (dorsal part of the cerebellum), suggesting a possible predilection for this region.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Pathological features of 78 metastatic or multicentric neoplasms involving the central nervous system in dogs

et al. 2018

View full text Add to dashboard Cite

RESUMO.-[Aspectos patológicos e distribuição de 78 neoplasias metastáticas ou multicêntricas envolvendo o sistema nervoso central de caninos.] Neoplasias secundárias envolvendo o sistema nervoso central (SNC) podem ocorrer por via hematógena ou por extensão direta. A ocorrência desta condição vem aumentando devido à expectativa de vida mais longa dos cães, bem como através do uso de quimioterápicos, os quais podem ampliar a sobrevida e, portanto, as chances para a ocorrência de metástases. O objetivo deste estudo foi analisar os aspectos epidemiológicos, como idade, raça e sexo dos animais afetados, bem como caracterizar os achados macroscópicos e microscópicos de neoplasmas com metástases envolvendo o SNC de 78 caninos e, baseado nestes dados, estimar a ocorrência e a frequência de neoplasias metastáticas ou multicêntricas. Fêmeas (71,79%) foram mais afetadas do que machos, com uma idade média de 9,5 anos e mediana de 10 anos. A maior parte dos casos apresentava distribuição multifocal (73,07%), e neoplasias de origem epitelial (50%) foram as mais frequentes. A localização neuroanatômica mais afetada foi o telencéfalo (61,1%). As neoplasias mamárias foram as mais frequentes (47,44%), seguidas por hemangiossarcoma (19,23%), linfoma (10,26%) e melanoma (6,41%). Osteossarcoma, sarcoma histiocítico e carcinoma pulmonar (2,56%) foram neoplasias menos frequentes. Os tipos de neoplasmas mamários mais observados foram o carcinoma anaplásico e o carcinoma micropapilar, nesses ABSTRACT.-Heck L.C., Cony F.G., Bianchi M.V., Driemeier D., Sonne L. & Pavarini S.P. 2018. Pathological features of 78 metastatic or multicentric neoplasms involving the central nervous system in dogs. Pesquisa Veterinária Brasileira 38 (10)1989-1998. Setor de Patologia Secondary neoplasms affecting the central nervous system (CNS) may occur through blood flow or direct extension. This condition occurrence has increased both due to a longer life expectancy of dogs, as well as with the employment of chemotherapeutics, which may increase the survival period and, thus, the odds of the occurrence of metastasis. The aim of this study was to analyze the epidemiological features, such as the age, breed and sex of the animals affected, as well as the gross and microscopic findings of the metastasis from neoplasms involving the CNS of 78 dogs, and, based on the data, estimate the occurrence and frequency of the metastatic or multicentric neoplasms. Females (71.79%) were most affected than males, with an average age of 9.5-years-old and a median of 10-years-old. Most of the cases had a multifocal distribution (73.07%), and epithelial neoplasms (50%) were the most common. Telencephalon was the most affected neuroanatomical region (61.1%). Mammary neoplasms were the most frequent (47.44%), followed by hemangiosarcoma (19.23%), lymphoma (10.26%) and melanoma (6.41%). Less common neoplasms included osteosarcoma, histiocytic sarcoma and lung carcinoma (2.56%). Mammary neoplasms were mainly composed of anaplastic and micropapillary carcinomas, of which only multifo...

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

Pathological features of 78 metastatic or multicentric neoplasms involving the central nervous system in dogs

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Os principais neoplasmas de cães diagnosticados em nossa rotina de necropsia incluem: mamários (29,9%), cutâneos (14,6%), hepáticos (10%), ósseos (8,1%) e renais (3,4%) (Fighera 2008). Apesar da alta frequência de ocorrência, não há estudos epidemiológicos e anatomopatoló-gicos sobre tumores hepáticos em cães dessa região, como ocorre para tumores cutâneos (Souza et al 2006), mamá-rios (Oliveira Filho et al 2010), ósseos (Trost et al 2012) e renais (Inkelmann et al 2011).…”

Section: Introductionunclassified

Prevalência e achados epidemiológicos, anatomopatológicos e imuno-histoquímicos dos tumores hepáticos malignos primários de cães da Região Central do Rio Grande do Sul (1965-2012)

Flores¹,

Bianchi

Kommers

et al. 2013

Pesq. Vet. Bras.

Self Cite

View full text Add to dashboard Cite

A prevalência e os aspectos epidemiológicos, anatomopatológicos e imuno-histoquímicos dos tumores hepáticos malignos primários (THMP) em cães foram estudados. De 7.373 cães necropsiados em 48 anos (1965-2012), 64 morreram de THMP, o que corresponde a 0,9% do total de cães que morreram por qualquer causa, 7,8% do total de cães que morreram por tumores em geral e 33,5% do total de cães que morreram por tumores hepáticos. Desses 64 casos de THMP, 51 foram revistos histologicamente, avaliados imuno-histoquimicamente e reclassificados como carcinomas (colangiocarcinomas [n=36], carcinomas hepatocelulares [n=9] e hepatocolangiocarcinoma [n=1]) e sarcomas (hemangiossarcomas [n=5]). Dos cães com colangiocarcinomas e carcinomas hepatocelulares em que a idade estava disponível nos protocolos, 64,7% e 77,8% eram idosos, respectivamente. Na necropsia, colangiocarcinomas caracterizaram-se principalmente por ocorrerem em um padrão multinodular (83,3%), enquanto carcinomas hepatocelulares ocorreram tanto de forma massiva (44,4%) quanto nodular (44,4%). Metástases extra-hepáticas foram vistas em 77,8% e 33,3% dos casos de colangiocarcinomas e carcinomas hepatocelulares, respectivamente, e em relação aos colangiocarcinomas afetaram principalmente pulmões (52,8%), linfonodos (50%) e peritônio (19,4%). Ascite (22,2%) e icterícia (22,2%) foram achados associados ocasionalmente com ambos os tumores. Na histologia, a maior parte dos colangiocarcinomas (86,1%) e dos carcinomas hepatocelulares (55,6%) tinha padrão tubular e trabecular, respectivamente. Na imuno-histoquímica, a maioria (63,9%) dos colangiocarcinomas demonstrou imunomarcação para CK7 e nenhum imunomarcou para Hep Par 1. A maioria (55,6%) dos carcinomas hepatocelulares demonstrou imunomarcação para Hep Par 1 e nenhum imunomarcou para CK7. Os resultados aqui apresentados demonstram uma altíssima prevalência de THMP, principalmente colangiocarcinomas, e servem para auxiliar, através dos achados de necropsia, histologia e imuno-histoquímica, patologistas veterinários no diagnóstico dessa tão comum forma de câncer em cães da Região Central do RS, Brasil.

show abstract

“…4,15,19,21,29 The histological diagnosis of primary OSA can be challenging. Because the different cell types that form OSAs originate from a common pluripotential mesenchymal precursor cell, OSAs may show marked histological diversity, making definitive diagnosis difficult.…”

mentioning

confidence: 99%

Osteocalcin and Osteonectin Expression in Canine Osteosarcoma

et al. 2016

View full text Add to dashboard Cite

Osteosarcoma (OSA) is a malignant heterogeneous primary bone tumor responsible for up to 90% of all primary bone tumors in dogs. In this study, osteocalcin (OC) and osteonectin (ON) immunoreactivity was evaluated in 23 canine OSAs, 4 chondrosarcomas, 4 fibrosarcomas, 2 hemangiosarcomas, and 4 histiocytic sarcomas. The effects of three different decalcification agents (ethylenediaminetetraetic acid [EDTA], formic acid and hydrochloric acid [HCl]) on the immunoreactivity for OC and ON was also assessed. Immunoreactivity to OC was present in 19/23 (83%) cases of OSA and all cases of chondrosarcoma. In three OSAs the extracellular matrix showed immunoreactivity to OC. None of the fibrosarcomas, histiocytic sarcomas or hemangiosarcomas showed immunoreactivity to OC. The sensitivity and specificity for OC in canine OSA in this study was 83% and 71% respectively. For ON, 100% of both OSAs (23/23) and non-OSAs (14/14) showed cytoplasmic immunoreactivity to this antibody, giving a sensitivity of 100% but a complete lack of specificity. There were no significant differences in immunoreactivity for OC and ON between the different decalcification agents used. In conclusion, OC showed high sensitivity for identifying OSA but it failed to distinguish between OSA and chondrosarcoma, and the osteoid produced by neoplastic cells in most cases did not show immunoreactivity to OC. These factors may limit the practical utility of OC in the diagnosis of OSA in dogs when chondrosarcoma is a differential diagnosis. ON showed no specificity in detecting OSA and has little practical application for the diagnosis of OSA in dogs.

show abstract

Primary bone neoplasms in dogs: 90 cases

Abstract: Pesq. Vet. Bras. 32( 12)

Cited by 18 publications

References 13 publications

Pathological features of 78 metastatic or multicentric neoplasms involving the central nervous system in dogs

Pathological features of 78 metastatic or multicentric neoplasms involving the central nervous system in dogs

Prevalência e achados epidemiológicos, anatomopatológicos e imuno-histoquímicos dos tumores hepáticos malignos primários de cães da Região Central do Rio Grande do Sul (1965-2012)

Osteocalcin and Osteonectin Expression in Canine Osteosarcoma

Contact Info

Product

Resources

About