Primary breast synovial sarcoma: a rare primary breast neoplasm

Tormo, V; Andreu, Francisco Javier

doi:10.1007/s12094-009-0456-1

Cited by 9 publications

(2 citation statements)

References 7 publications

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“…Synovial sarcoma tends to arise in young adults, typically 15–40 years of age 1. They are often asymptomatic; however, pain is not an infrequent presentation as in our case 2. Grossly, synovial sarcomas appear as a well-circumscribed, firm nodule, which is often greyish-pink in colour.…”

Section: Discussionmentioning

confidence: 63%

An unusual breast mass: primary synovial sarcoma

2013

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We describe a 54-year-old woman presenting with mastalgia and a 6 mm breast lesion on imaging. Core biopsy revealed a lesion characterised by a predominant epithelioid and a minor spindle cell component. Our differential diagnosis included intraduct papilloma/adenoma and adenomyoepithelioma. However, initial immunohistochemistry did not support these diagnoses and further immunohistochemistry raised the possibility of a synovial sarcoma. This was confirmed with the finding, using fluorescence in-situ hybridisation, of the characteristic translocation t(x; 18) (p11.2; q11.2). Establishing a diagnosis of synovial sarcoma at unusual sites may be difficult, especially when limited tissue is available, for example, within a core biopsy. In this case, immunohistochemistry was useful, but cytogenetics was the key additional investigation. It is important to consider the possibility of rare tumours when the morphological and immunohistochemical features of a lesion initially appear conflicting or inconclusive.

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Section: Discussionmentioning

confidence: 63%

An unusual breast mass: primary synovial sarcoma

2013

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“…It could resemble ES/PNET [10]. Synovial sarcoma rarely involves the breast and the axilla [4,8,11]. Therefore, occurrence of this rare type of synovial sarcoma in the breast either as a primary breast neoplasm or secondary metastasis might bring diagnostic challenges for the pathologists.…”

Section: Discussionmentioning

confidence: 99%

Breast metaplastic carcinoma with unusual small cell component

AbdullGaffar

Ghazi

Mohamed

et al. 2013

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Small round cell mesenchymal component in breast metaplastic carcinoma is very rare and could be confused with other small round cell neoplasms of the breast. Synovial sarcoma exceptionally involves the breast and rarely may show a poorly differentiated small round cell component. These unusual small round cell components in biphasic metaplastic carcinoma and synovial sarcoma as well as collision tumor of ductal carcinoma and Ewing sarcoma might have overlapping clinical, histologic and immunohistochemical features which make distinction between these neoplasms difficult for the pathologists. Separation between these neoplasms is important for the treating oncologists because each tumor type has different prognostic implications and treatment modalities. Certain immunohistochemical markers might help, but cytogenetics study is the final confirmatory test. We report a unique example of a biphasic breast neoplasm in a 43-year-old woman that showed a combination of a minor central component of adenocarcinoma distinct from the bulky surrounding component of small round cell tumor. The histologic and immunohistochemical features were overlapping between metaplastic carcinoma, poorly differentiated synovial sarcoma and a composite collision tumor of invasive ductal carcinoma and Ewing sarcoma.

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Nonepithelial Malignancies of the Breast

Soybir¹

2019

Breast Disease

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Primary breast synovial sarcoma: a rare primary breast neoplasm

Cited by 9 publications

References 7 publications

An unusual breast mass: primary synovial sarcoma

An unusual breast mass: primary synovial sarcoma

Breast metaplastic carcinoma with unusual small cell component

Nonepithelial Malignancies of the Breast

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