Primary Carcinoid Tumor of the Testis With Metastasis to the Upper Vertebrae

Shimura, Satoru; Uchida, Τοyoaki; Shitara, Tetsuya; Nishimura, Kiyoshi; Murayama, Masakazu; Honda, Naoyasu; Koshiba, Ken

doi:10.5980/jpnjurol1989.82.1157

Cited by 7 publications

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“…carcinoid heart disease, and metastatic patterns such as skin and skeletal metastases, have been discovered. These complications were described in two more recent cases of testicular carcinoid [29,32]. One case report mentioned a metastasis to the heart [32] and autopsy showed nests of tumour cells in the endocardium.…”

Section: Resultsmentioning

confidence: 99%

“…Metastases were described in seven of the 44 cases in group 1 [8,9,15,28,29,32]. The sites of these metastases were liver in two and one each in the lung, cervical and thoracic vertebrae, and the abdominal wall; one patient developed metastases in the heart, lung and skin, and another developed them in the contralateral testicle and lymph nodes.…”

Section: Resultsmentioning

confidence: 99%

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Carcinoid tumours of the testis

Stroosma

Delaere

2008

BJU International

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OBJECTIVETo review previous reports of carcinoid (an endocrine tumour mostly of the gastrointestinal tract) tumours of the testis.METHODSCarcinoid tumours of the testis are rare and can be divided into primary carcinoid (group 1), testicular metastasis from another location (group 2) and carcinoid within a testicular teratoma (group 3). A case of testicular carcinoid within our clinic prompted us to review previous reports; all the cases found were assessed for patient and tumour characteristics, diagnostic tools used, treatment and prognosis.RESULTSIn all, 62 cases were assessed and divided into groups 1 (44 patients), 2 (six) and 3 (12), respectively. Seven patients in group 1 developed metastases. A wide variety of diagnostic tools was used to search for other tumour sites. All patients were treated with orchidectomy. Three patients with a primary carcinoid were treated with adjuvant chemotherapy (two) or radiotherapy (one), with unknown results. All but one of the nine patients who died were known to have metastasis, either from a primary testicular carcinoid or testicular metastases from an intestinal carcinoid.CONCLUSIONWhen a testicular carcinoid tumour is discovered, other tumour sites should be excluded. The most useful diagnostic tools for this purpose seem to be urinary 5‐hydroxyindoleacetic acid measurement, somatostatin receptor scintigraphy, computed tomography and video‐capsule endoscopy. Localized testicular carcinoid tumours have an excellent prognosis after orchidectomy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Carcinoid tumours of the testis

Stroosma

Delaere

2008

BJU International

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“…Because of improved prognosis and longer survival time due to advanced diagnostic and therapeutic techniques other late complications involving metastasis to skin and skeletal system and carcinoid heart disease (CHD) are reported [20,21]. Long term follow up is recommended since delayed metastasis has been reported even up to several years with one case of metastasis occurring after 17 years of initial diagnosis [8].…”

Section: Discussionmentioning

confidence: 99%

Primary Neuroendocrine Tumor (Carcinoid Tumor) of the Testis: A Case Report with Review of Literature

Heimann

2015

Am J Case Rep

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Patient: Male, 34Final Diagnosis: Primary neuroendocrine tumor of the testisSymptoms: Pain • swellingMedication: NoneClinical Procedure: Radical orchiectomySpecialty: OncologyObjective:Rare diseaseBackground:The term carcinoid (Karzinoide) was coined by German pathologist Oberndorfer in 1907. Primary testicular carcinoid tumors (TCT) are rare, constituting 0.23% of all testicular tumors. In this report we describe a case of primary TCT of the testis and present the results of an extensive literature review to cover all the aspects of carcinoid tumor, including the definition, classification, origin, presentation, diagnostic evaluation, management, prognosis, and follow-up.Case Report:A 34-year-old male presented with chronic right scrotal swelling with recent onset of pain. Radical orchiectomy revealed a solid intratesticular tumor confined to the testis and epididymis, without lymphovascular invasion. Histology was consistent with neuroendocrine carcinoma. The tumor was staged as pT1 N0 M0 S2. Immunohistochemistry was positive for neuroendocrine markers. An extratesticular carcinoid tumor was ruled out. Urinary excretion of 5-hydroxyindoleacetic acid and Chromogranin A were within normal range.Conclusions:It is important to follow serotonin levels since the elevated levels of serotonin can cause carcinoid heart disease. If metastatic lesions are not accessible for resection, a trial of octreotide therapy can be given. This case also adds to the rare reports in the literature of primary carcinoid tumors of the testis having low malignant potential. The literature review highlights new diagnostic and therapeutic interventions and stresses the importance of long-term follow-up due to evidence of delayed metastasis or recurrences and also due to emergence of new complications as a result of improved prognosis and prolonged survival.

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“…Wang et al reported metastases in none of 20 typical primary testicular cases and in 1 of 4 cases with atypical morphology [3]. Documented sites of metastases include the para-aortic lymph nodes, lungs, vertebrae, retroperitoneum, skin and skeletal muscle [17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Well Differentiated Neuroendocrine Carcinoma of the Testis in a Nigerian Male

Nz¹,

Fc²,

Dawodu³

et al. 2015

JCR

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Abstract:Testicular carcinoids are very rare tumors that account for less than 1% of all testicular neoplasms. We present the first case of a testicular carcinoid tumor in a Nigerian male who had radical orchiectomy on account of a painful left testicular mass. Histology showed a thinly encapsulated lesion composed of sheets of closely packed spindle cells having a uniform 'salt-and-pepper' chromatin pattern, and moderate pale cytoplasm within a scant dense fibrocollagenous stroma. Mitoses were scanty and necrosis absent. There was no evidence of an intratubular germ cell tumor. The lesional cells stained positive, on immunohistochemistry, for CD 56, NSE and S100, though they were negative for chromogranin A and synaptophysin. They also showed positivity for AE 1/3 in a para-nuclear dot-like fashion. There was complete negativity for CD 99, CD 117, PLAP and EMA. The cells were weakly positivity for inhibin, while CD 45 marked only a small population of lymphocytes. A diagnosis of a spindle cell type carcinoid tumour/well differentiated neuroendocrine carcinoma was made. The presence of a fibrous capsule suggested a primary testicular lesion and subsequent abdomino-pelvic CT scan showed no intra-abdominal primaries. However, investigations to rule out a focus from the lungs are yet to be done.

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Primary Carcinoid Tumor of the Testis With Metastasis to the Upper Vertebrae

Cited by 7 publications

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Carcinoid tumours of the testis

Carcinoid tumours of the testis

Primary Neuroendocrine Tumor (Carcinoid Tumor) of the Testis: A Case Report with Review of Literature

Well Differentiated Neuroendocrine Carcinoma of the Testis in a Nigerian Male

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