Primary Carcinoid Tumor of the Ovary: MR Imaging Characteristics with Pathologic Correlation

Takeuchi, Mayumi; Matsuzaki, Kei; Uehara, Hisanori

doi:10.2463/mrms.10.205

Cited by 25 publications

(27 citation statements)

References 8 publications

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“…Primary tumors are usually unilateral with a relatively benign course. They are usually solid tumors and often associated with mature cystic teratomas or mucinous tumors (87). As the venous drainage of the affected ovary bypasses the liver, carcinoid syndrome is noted in up to onethird of cases and is seen without liver metastasis (88).…”

Section: Ovarymentioning

confidence: 99%

“…At CT, they usually appear as solid enhancing masses often indistinguishable from other ovarian neoplasms (Fig 29). The solid components of the tumors have fibroma-like hypointensity on T1and T2-weighted images with diffusion restriction due to hypercellularity, whereas other benign fibrous T2-hypointense ovarian tumors usually show low signal intensity on diffusion-weighted images (87). On the other hand, mucinous carcinoid tumors can demonstrate high signal intensity on both T1-and T2-weighted images (90).…”

Section: Ovarymentioning

confidence: 99%

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Multimodality Imaging Findings in Carcinoid Tumors: A Head-to-Toe Spectrum

et al. 2017

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Carcinoid tumors are a rare biologically heterogeneous group of neuroendocrine tumors with a spectrum ranging from benign indolent to aggressive metastatic tumors. They belong to the category of amine precursor uptake and decarboxylase tumors, or apudomas. The most common sites for primary locations are the gastrointestinal and respiratory tracts; however, any organ can be involved. The clinical presentation depends on location, aggressiveness, production of biologically active amines and peptides, paraneoplastic syndromes, and tendency for metastasis. Their reported age-adjusted incidence has increased in recent years, partly due to improved detection at radiologic imaging and endoscopy. Not a ll neuroendocrine cell tumors are carcinoids. Numerous systems have been proposed regarding their nomenclature and classification. Cross-sectional and functional imaging plays an important role in diagnosis, lesion characterization, and staging. Awareness of nomenclature, classification, common sites of involvement, and imaging presentation are pivotal for making the diagnosis. Knowledge of the diverse clinical, pathologic, and radiologic spectrum of carcinoid tumors involving various organs of the body is important for diagnosis and patient management. RSNA, 2017.

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Section: Ovarymentioning

confidence: 99%

Section: Ovarymentioning

confidence: 99%

Multimodality Imaging Findings in Carcinoid Tumors: A Head-to-Toe Spectrum

et al. 2017

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“…They are usually of primary gastrointestinal origin. 3,4 Primary ovarian carcinoids usually behave in a benign fashion but metastatic carcinoids are aggressive and associated with poor outcome. Hence distinction between pure primary ovarian carcinoid and metastatic carcinoid is crucial and it has alsoclinical and prognostic importance.…”

Section: Introductionmentioning

confidence: 99%

“…7 CDX2 expression by carcinoid tumors points to GI origin. 4 Midgut tumors and their metastatic tumors express high level of CDX2 compared to foregut and hindgut carcinoids. [8][9][10] CDX2 positivity is seen in tumors arising in small intestine(95%), appendix (92%) and duodenum (80%) but rare in tumors of colorectum (12%) and stomach (0%).…”

Section: Introductionmentioning

confidence: 99%

Metastatic carcinoid tumor of the ovary-A rare entity and role of CDX2 to distinguish pure primary carcinoid from metastatic carcinoid to the ovary

Giri¹,

Senapati²,

Sahu³

2020

IJOGR

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Metastatic ovarian carcinoid is a very rare entity which is usually of primary gastrointestinal origin. Distinction is difficult between pure primary ovarian carcinoid from metastatic carcinoid tumor of ovary, but distinction is very much crucial because it has clinical and prognostic implications.We are reporting a case of a 55yr old female presented with abdominal pain. Ultrasonography revealed bilateral solid ovarian mass. Macroscopically both the ovaries were enlarged, solid with surface nodularity. Morphology showed tumor cells mostly in insular and acinar configuration, round to oval nucleus, stippled chromatin and granular eosinophilic cytoplasm. IHC for synaptophysin and chromograin were strong positive. CDX2 was done which showed strong nuclear positive in 80% of tumor cells. The tumor was diagnosed as a metastatic carcinoid tumor to the ovary and primary tumor in the small intestine. This case was reported because of its rarity and usefulness of CDX2 to distinguish pure primary carcinoid from metastatic carcinoid to ovary.

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“…They are usually unilateral and mostly seen in the perimenopausal and postmenopausal women. Generally, they occur in association with mature cystic teratomas or mucinous tumors [3]. There are four histological types of primary ovarian carcinoid tumors; insular, trabecular, strumal and mucinous.…”

Section: Introductionmentioning

confidence: 99%

A Primary Insular Type Carcinoid Tumor Arising in a Mature Cystic Teratoma of the Ovary: A Case Report

İlker¹

2012

J Clin Case Rep

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Background: Carcinoid tumors are rare neoplasms of the diffuse peripheral neuroendocrine system which produce biological amines and various peptides. Carcinoid tumors most commonly occur in the gastrointestinal tract. Primary ovarian carcinoids are rarely seen; they consist less than 0.1% of all ovarian cancers and 0.3% of all carcinoid tumors.Case: Here, we present a rare case of primary carcinoid tumor, insular type, arising in a mature cystic teratoma of the ovary. Conclusion:Surgical excision of the tumor is usually sufficient treatment for most of the patients.

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Primary Carcinoid Tumor of the Ovary: MR Imaging Characteristics with Pathologic Correlation

Cited by 25 publications

References 8 publications

Multimodality Imaging Findings in Carcinoid Tumors: A Head-to-Toe Spectrum

Multimodality Imaging Findings in Carcinoid Tumors: A Head-to-Toe Spectrum

Metastatic carcinoid tumor of the ovary-A rare entity and role of CDX2 to distinguish pure primary carcinoid from metastatic carcinoid to the ovary

A Primary Insular Type Carcinoid Tumor Arising in a Mature Cystic Teratoma of the Ovary: A Case Report

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