Primary carcinoma of male urethra

Hopkins, Stanley C.; Nag, Subir; Soloway, Mark S.

doi:10.1016/0090-4295(84)90005-0

Cited by 53 publications

(18 citation statements)

References 14 publications

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“…The prognosis of urethral cancer in localized disease with complete surgical resection is good while that of advanced disease remains poor. The overall survival of all stages is around 50%, but only 5-15% for posterior tumors [7,21,36,37]. For urethral carcinoma in females as well as for posterior urethral lesions in males, the prognosis is less good than for anterior urethral lesions in males.…”

Section: Discussionmentioning

confidence: 99%

The Treatment of Primary Urethral Carcinoma – the Dilemmas of a Rare Condition: Experience with Partial Urethrectomy and Adjuvant Chemotherapy

et al. 2001

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Background: Primary urethral carcinoma is a very rare condition, and no large-scale experience with such cases has been published. Treatment will therefore have to follow rules established for the treatment of similar conditions. Patients: Six cases of primary urethral carcinoma (5 male, 1 female) who had been treated at our institution between 1995 and 1999 were retrospectively analyzed. In 3 male cases, a primary urothelial carcinoma of the distal urethra was treated by distal urethrectomy only. In 3 other cases with locally advanced tumors and/or lymph node metastases surgical treatment was followed by adjuvant cisplatinum-containing chemotherapy. Results: In the 3 cases with distal urethral carcinoma, partial urethrectomy with preservation of the penis resulted in cure, with a follow-up of 12–71 months. In the cases with advanced disease, adjuvant chemotherapy after surgery has resulted in complete remissions in all 3 cases, with a follow-up of 4–47 months at present. Conclusions: In localized, noninvasive carcinoma of the distal male urethra, partial urethrectomy seems adequate and the avoidance of penile amputation justified. In advanced cases, after local excision and lymphadenectomy adjuvant chemotherapy which by necessity must follow the guidelines established for the treatment of other urothelial or squamous cell malignancies seems to be beneficial.

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Section: Discussionmentioning

confidence: 99%

The Treatment of Primary Urethral Carcinoma – the Dilemmas of a Rare Condition: Experience with Partial Urethrectomy and Adjuvant Chemotherapy

et al. 2001

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“…Six cents cas atteints d'une tumeur de l'urètre masculin ont été relevés dans la littérature 3 . L'âge moyen de survenue est de 60 ans 4 .…”

Section: Discussionunclassified

“…Son traitement est essentiellement chirurgical mais souvent mutilant. L'espoir actuel réside dans l'association d'une radiothérapie et d'une chimiothérapie mais le pronostic reste défavorable dans la majorité des cas 3 . En parallèle à la description d'un cas de cancer épidermoïde de l'urètre chez l'homme révélé par une rupture de l'urètre membraneux, nous présentons une revue de la littérature et discutons des aspects épidémiologiques, cliniques et thérapeutiques de cette pathologie.…”

Section: Introductionunclassified

Carcinome épidermoïde de l’urètre masculin révélé par une rupture spontanée de l’urètre

Ghorbel

Hafsia

Derouiche

et al. 2013

CUAJ

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Le carcinome épidermoïde de l’urètre masculin est une tumeurrare, les tumeurs de l’urètre tous types confondus représentantmoins de 1 % des tumeurs de l’appareil urinaire. Le pronosticreste défavorable malgré un traitement chirurgical énergique. Laradiochimiothérapie semble être un traitement prometteur, maisson rôle doit être défini par d’autres études.Nous rapportons un cas rare de carcinome épidermoïde del’urètre bulbo-membraneux découvert à un stade localement avancéaprès observation d’une rupture urétrale transtumorale chez unhomme âgé de 70 ans. Le patient a été traité, après drainage vésical,par une irradiation externe associée à une chimiothérapie parcisplatine, et est décédé après progression de la maladie sur un an.La rupture spontanée de l’urètre transtumorale est un modede découverte exceptionnel témoignant d’une évolution localedéfavorable, ce qui rend ces tumeurs difficilement opérables.Cependant, l’espoir actuel réside dans des protocoles thérapeutiquesassociant radiothérapie et chimiothérapie.

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“…Generally, for malignant tumors originating from the distal urethra, partial or total penectomy with bilateral inguinal lymph node dissection has been recommended 6 and this is the case in malignant melanoma. 7 In contrast, Paw-Sang et al pointed out the high risk of local recurrence after penile amputation and emphasized the necessity of more extensive surgery, such as cystourethrectomy.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the male urethra

Watanabe

Yamamoto

Souma³

et al. 2000

Int J of Urology

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Background: We describe a rare case of malignant melanoma originating from the male urethra. Methods/Results: This case, which presented a tan-colored lesion at the distal urethra on urethroscopy, was considered as transitional cell carcinoma by transurethral biopsy. Pathologic examination of widely resected urethra revealed scattering cells, which included melanin granules in cytoplasm, and then immunohistochemical stains established the diagnosis as amelanotic melanoma. Although partial penectomy and inguinal lymph node dissection were subsequently performed, 7 months later, total cystourethrectomy was required because of multifocal recurrence at the residual urethra. Conclusions:In cases of amelanotic melanoma, it should be noted that a lack of melanin granules in tumor cells may lead pathologists and urologists to a misdiagnosis due to the histologic nonspecific appearance. With respect to surgical management, of significance is the fact that malignant melanoma may progress multifocally along the total urethra; therefore, total urethrectomy should be considered as radical surgery for the primary site, even if the tumor is confined to the distal urethra.

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Primary carcinoma of male urethra

Cited by 53 publications

References 14 publications

The Treatment of Primary Urethral Carcinoma – the Dilemmas of a Rare Condition: Experience with Partial Urethrectomy and Adjuvant Chemotherapy

The Treatment of Primary Urethral Carcinoma – the Dilemmas of a Rare Condition: Experience with Partial Urethrectomy and Adjuvant Chemotherapy

Carcinome épidermoïde de l’urètre masculin révélé par une rupture spontanée de l’urètre

Primary malignant melanoma of the male urethra

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