Primary malignant melanoma of the male urethra

Watanabe, Jun; Yamamoto, Shingo; Souma, Takahito; Hida, S; Takasu, Kosho

doi:10.1046/j.1442-2042.2000.00206.x

Cited by 23 publications

(11 citation statements)

References 10 publications

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“…Watanabe et al . recommended that, even if the primary tumor was confined to the distal urethra, radical resection including the total urethra should be considered due to the high risk of multicentric progression of the disease 4 . Although our case performed well, we believe that, because phallectomy impacts on the patient both sexually and mentally, all urologists should make efforts to preserve the penile shaft if an early‐stage tumor locates solitarily in the distal urethra.…”

Section: Discussionmentioning

confidence: 83%

Primary malignant melanoma of the male urethra

Kubo¹,

Miyawaki²,

Kawagoe³

et al. 2002

Int J of Urology

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We report a case of primary malignant melanoma of the male urethra in a patient whose penile shaft was successfully preserved, but who proceeded to acute renal failure (ARF) after interferon (IFN)-β adjuvant immunotherapy. Primary malignant melanoma of the male urethra is rare and usually shows highly malignant potential. Therefore, urologists must often perform phallectomy, which impacts on the patient both sexually and mentally. A 64-year-old man presented at Saiseikai Sendai Hospital with asymptomatic gross hematuria and was diagnosed as distal urethral tumor. We predicted the highly malignant potential of this tumor from the urethroscopic finding and from urinary cytological examination. We did not select trans-urethral resection (TUR), but selected partial urethrectomy. This patient proceeded to ARF 1 month after natural IFN-β treatment as an adjuvant immunotherapy. As IFN-β rarely induces the delayed renal failure, urologists should be aware of renal dysfunction after IFN-β therapy for the treatment of malignant melanoma.

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Section: Discussionmentioning

confidence: 83%

Primary malignant melanoma of the male urethra

Kubo¹,

Miyawaki²,

Kawagoe³

et al. 2002

Int J of Urology

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“…The differential diagnosis of amelanotic (non-pigmented) melanoma mostly includes neoplastic entities such as high grade urothelial cell carcinoma (HGUC), prostatic adenocarcinoma, and other rare poorly-differentiated malignant tumors from neighboring organs or distant metastases from breast or stomach. 11 Distinguishing melanoma from these tumors can be challenging. HGUC displays a very high N/C ratio with irregular, angulated, and hyperchromatic nuclei.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the urethra detected by urine cytology in a male patient

DeSimone

Hoda

2015

Diagnostic Cytopathology

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Dear Editor:We read with interest the recent article by Hori et al. describing primary bladder melanoma diagnosed on voided urine cytology.1 Herein, we present a case of primary urethral melanoma diagnosed as suspicious for melanoma on voided urine cytology. To our knowledge, there have been rare case reports of primary bladder melanoma and one report of a primary urethral melanoma detected by urine cytology. 1-3 CaseThe patient was an 81-year-old man who presented to his urologist with benign prostatic hyperplasia and bladder outlet obstruction in the setting of a long history of lower urinary tract symptoms and hematuria for several months. Bladder outlet obstruction was demonstrated on urodynamics and attributed to an enlarged prostate. To evaluate for malignancy, voided urine was submitted and prepared as one Papanicolaou (Pap)-stained ThinPrepV R (TP) slide (Hologic, Boxborough, MA). Two prior voided urine specimens prepared similarly were negative for malignant cells over the prior 7 months. On microscopic examination, there were scattered large abnormal cells occurring singly and in small clusters (Figs. 1 and 2). The cells had enlarged nuclei, high nuclear-to-cytoplasmic (N/C) ratios, and prominent nucleoli. Several of the cells were bi-and multi-nucleate, and many contained dark-brown cytoplasmic pigment. The findings were suspicious for melanoma.A biopsy of the penile urethra performed 5 months later was diagnosed as melanoma (Fig. 3), confirmed by positive immunostaining for S100, HMB-45, and Melan-A, and negative pancytokeratin. A subsequent right axillary lymph node biopsy revealed metastatic melanoma.

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“…[7] Moreover, we did not perform inguinal lymphadenectomy, because the value of inguinal lymph dissection for staging and therapy for urethral melanoma has been questionable. [89]…”

Section: Discussionmentioning

confidence: 99%

Radical urethrectomy with bladder preservation and continent catheterizable stoma (Yang-Monti tecnique)

Maestro¹,

Martínez‐Piñeiro²,

González³

2012

Indian J Urol

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Malignant melanoma originating in the urethra is considered extremely rare and has a very poor prognosis. Consequently, therapeutic reviews are retrospective describing assorted treatments. We report how to perform a radical urethrectomy with bladder preservation and a continent catheterizable stoma (Yang-Monti technique) Radical urethrectomy with bladder preservation and a continent catheterizable stoma may be appropriate in selected patients with tumours that do not invade the bladder neck.

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Primary malignant melanoma of the male urethra

Cited by 23 publications

References 10 publications

Primary malignant melanoma of the male urethra

Primary malignant melanoma of the male urethra

Primary malignant melanoma of the urethra detected by urine cytology in a male patient

Radical urethrectomy with bladder preservation and continent catheterizable stoma (Yang-Monti tecnique)

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