Primary Cardiac Angiosarcoma Treated With Positron Emission Tomography/Magnetic Resonance Imaging–Guided Adaptive Radiotherapy

Elsayad, Khaled; Lehrich, Philipp; Yppaerilae-Wolters, Heidi; Dieckmann, Chantal; Kříž, Jan; Haverkamp, Uwe; Eich, Hans Theodor

doi:10.1016/j.cjca.2015.07.010

Cited by 9 publications

(6 citation statements)

References 3 publications

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“…Data from several sources have identified chemotherapy and/or radiotherapy as optimal options after radical or debulking surgery [25, 26]. In 1997, Kakizaki et al published a paper in which they found that a PCAS patient survived for 30 months after surgery since he was treated with a combination of chemotherapy and immunotherapy [27].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics associated with primary cardiac angiosarcoma outcomes: a surveillance, epidemiology and end result analysis

et al. 2019

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Background Primary cardiac angiosarcoma (PCAS) is a rare type of tumour. Furthermore, descriptions of the demographic features and prognostic factors of PCAS patients have been poorly reported. Methods A population cohort study was conducted using retrospectively extracted data from the SEER (Surveillance, Epidemiology and End Results) database for patients with histological diagnoses of PCAS; the extracted information included demographic, treatment and outcome data. Results A total of 168 cases of PCAS from 1973 to 2013 were included. The mean age at diagnosis was 44.4 ± 15.5 years. PCAS was more prevalent in men than in women. The majority of PCAS patients were white (67.3%), while the incidence of PCAS in black individuals was relatively infrequent (19.0%). In addition, 87 cases were classified as distant stage, 44 as regional stage, and 33 as localized stage. The median disease-specific survival (DSS) was 7.22 months, and the 1-, 2- and 5-year DSS rate for PCAS patients was 34.7%, 14.3% and 10.2%, respectively. Further multivariate analyses showed that an age at (greater than or equal to) 45 years (HR 2.165), no radiotherapy (HR 1.629), tumour size > 5 cm (HR 3.182), and the summary stage was associated with worse PCAS-related survival. Cancer-directed surgery and radiotherapy significantly improved the DSS for patients with PCAS ( P < 0.05). The C-index of the nomograms was 0.706 (95% CI 0.654–0.758), and the calibration curves showed good agreement between the nomogram prediction and actual observation. Conclusion PCAS is a rare cancer that is prone to have poor prognoses. To understand PCAS more thoroughly, more cases with adequate information are needed.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics associated with primary cardiac angiosarcoma outcomes: a surveillance, epidemiology and end result analysis

et al. 2019

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“…Primary cardiac angiosarcoma compared to other STS subtypes particularly prone to metastatic spread and survival outcome is described as even less favorable with an estimated median survival of 14 months [ 4 , 5 ]. For the treatment of primary cardiac angiosarcoma, radio- and/or chemotherapy are usually reserved for inoperable or metastatic disease or given to patients as adjuvant treatment for those with residual tumor [ 6 , 7 ]. A multimodality approach including radiotherapy and chemotherapy may only be effective for a selected subgroup of patients and radiotherapy dosage is limited by the sensitivity of lung and heart to radiation injury [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report

Schur¹,

Hamacher²,

Brodowicz³

2016

Case Rep Oncol

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Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Fury et al.: Cancer J 2005;11: 241–247]. Based on the prevailing literature, we report a 48-year-old woman diagnosed with primary metastatic cardiac angiosarcoma who showed a severe hypersensitivity reaction to conventional chemotherapy with taxanes but an excellent response to treatment with the multitargeted receptor tyrosine kinase inhibitor pazopanib.

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“…1g-i). Weekly, paclitaxel (50 mg/m 2 ) was administered intravenously concurrent with adaptive radiation [7]. Unfortunately, multiple pulmonary and hepatic metastases were detected 8 weeks after the completion of RT.…”

Section: Case Reportsmentioning

confidence: 99%

“…With MRI, PCSs usually exhibit heterogeneous signal intensity due to intratumoral hemorrhage, a cauliflower appearance on T1-weighted spin echo images, and a strong irregular enhancement on contrast MRI [3,6]. Recently, the application of positron emission tomography (PET)/MRI to intrathoracic tumors has also shown promising results [7,8], with a maximum standardized uptake value (SUV max ) of 8.0 reported for malignant primary cardiac tumors versus a value of 2.8 for benign tumors [9]. Myocardial tissue often shows a high uptake of fluorodeoxyglucose (FDG).…”

Section: Introductionmentioning

confidence: 99%

Advances in Image-Guided Radiation Therapy for Primary Cardiac Angiosarcoma: The Role of PET-CT and MRI

Elsayad¹,

Scobioala²,

Kříž³

et al. 2016

Oncol Res Treat

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Background: With advances in modern diagnostic and therapeutic modalities, the main goal of intrathoracic radiation treatment is to reduce treatment-related toxicities. Here, we describe a series of cases that involved positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI)-based radiation therapy (RT) for the treatment of primary cardiac angiosarcoma (PCA). Patients and Methods: The medical records of 3 patients who underwent image-guided RT at our department between 2012 and 2015 were analyzed. Results: 3 patients with PCA underwent pre-therapeutic imaging with fluorodeoxyglucose (FDG)-PET/CT (n = 3), as well as PET/MRI (n = 2) or MRI alone (n = 1). 2 patients underwent primary tumor resection (cases 1 and 2). The tumor in case 3 was unresectable and the patient underwent definitive chemoradiation. Intensity-modulated RT was applied with a median RT dose of 50.4 Gy. At the end of the study, 2 of the patients had survived for 35 and 16 months post-treatment (cases 1 and 3, respectively), and no evidence of tumor progression has since been detected. Conclusion: For the cases examined, RT was a feasible and tolerable treatment for PCA, and FDG-PET-MRI successfully characterized each PCA for therapy planning.

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Primary Cardiac Angiosarcoma Treated With Positron Emission Tomography/Magnetic Resonance Imaging–Guided Adaptive Radiotherapy

Cited by 9 publications

References 3 publications

Clinical characteristics associated with primary cardiac angiosarcoma outcomes: a surveillance, epidemiology and end result analysis

Clinical characteristics associated with primary cardiac angiosarcoma outcomes: a surveillance, epidemiology and end result analysis

Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report

Advances in Image-Guided Radiation Therapy for Primary Cardiac Angiosarcoma: The Role of PET-CT and MRI

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