Primary Cardiac High-grade Myxofibrosarcoma Presenting with Multiple Brain Metastases: A Case Report

Abstract

Herein we describe the case of a young patient who presented with a recent history of epilepsy due to multiple brain lesions; he did not complain about any cardiopulmonary impairments. The patient died as a consequence of hemorrhagic progression of brain metastatic disease. Regardless of a thorough investigation, the heart tumor remained occult. Primary cardiac tumors are very rare entities. Most of these are benign, but approximately 25% are malignant, and the majority of these are sarcomas. Myxofibrosarcoma and osteosarcoma are exceptionally rare. To date, we find only small series of cardiac myxofibrosarcoma, and to our knowledge, this one exceptionally presented with multiple brain metastatic lesions without cardiopulmonary symptoms.

Myxofibrosarcoma of the heart: case series

“…Снижение амплитуды зубца Т может быть вызвано повреждением миокарда и эндокарда. Метастазы МФС сердца могут проявляться эпилептическими приступами, острым нарушением мозгового кровообращения, внутримозговыми гематомами [18].…”

Brain metastasis from a thoracic myxofibrosarcoma: A case report and literature review

“…Intracranial MFS is rare and some reports have described cases without extracranial sites. [ 3 , 6 , 14 , 16 ] Sarrami et al . reported a case of MFS with infiltration of the pons, cerebellum, and basal surface of the left temporal lobe without any visible masses.…”

“…Intracranial MFS is rare and some reports have described cases without extracranial sites. [3,6,14,16] Sarrami et al reported a case of MFS with infiltration of the pons, cerebellum, and basal surface of the left temporal lobe without any visible masses. [16] A 55-year-old man presented with MFS presenting as an acute cerebral hemorrhage, with subsequent development of lung metastases.…”

“…[6] To the best of our knowledge, only seven cases of brain metastasis as a consequence of MFS have been reported, and this is the first case of metastasis from the chest wall. [3,4,[10][11][12]17,18] e study, number of patients, primary site, age, sex, and outcome of these studies are summarized in Table 1.…”

Primary cardiac myxofibrosarcoma of the left atrial and pericardium: a case report

“…Myxo brosarcoma is categorized from low-grade neoplasm to high-grade neoplasm. A low-grade myxo brosarcoma tends to metastasize locally while high-grade myxo brosarcomas invade local and adjacent tissues and are associated with distant metastasis to the lung, bone, brain, and lymph nodes (9). The local recurrence rate and distant metastasis rate were 42.9% and 19.0% respectively (4).…”