Primary Cardiac Lymphoma in a Cat

Woldemeskel, Moges

doi:10.1016/j.jcpa.2019.10.192

Cited by 6 publications

(9 citation statements)

References 15 publications

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“…The mediastinal type of lymphoma in cats was registered less frequently and statistically, the number of cases did not exceed 20% (Woldemeskel, 2020). Characteristic multifocal lesions were detected in the thymus, pleura, and mediastinal lymph nodes.…”

Section: Introductionmentioning

confidence: 80%

Pathohistological features of mediastinal lymphoma in domestic cats

Oriekhova

Shchebentovska

2022

Regul. Mech. Biosyst.

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The article covers two clinical cases of domestic cats suffering from a mediastinal form of lymphoma and provides their cytological, immunohistochemical, and pathohistological verification. The lymphoma immunophenotyping method using the B-cell markers CD79a and CD3 was used to identify T-cells. The mediastinal type of lymphoma in cats is usually rarely registered and statistically, the number of cases does not exceed 20%, which is consistent with our observations. Shortness of breath, difficulty with swallowing, lack of appetite, cyanotic mucous membranes, lymphadenomegaly of the mediastinal lymph nodes and effusion in the chest cavity were found in the clinically ill cats. An X-ray examination of the chest cavity revealed an increased contrast in the mediastinal area and displacement of the lungs towards the spine. A complete blood count revealed lymphopenia. Cytological smears of the chest cavity transudates revealed mostly monomorphic lymphoblasts with large rounded hyperchromic nuclei and narrow cytoplasm stained in light blue. The karyoplasm was somewhat granular, the nucleoli were visible, and the mitoses were atypical and numerous. The cytological picture in biopsy samples of mediastinal lymph nodes was characterized by a monomorphic population of lymphoblasts with an eccentrically located nucleus and moderately basophilic karyoplasm. The cell cytoplasm was vacuolated in some places, with presence of atypical mitotic figures. Most of the cells had two nuclei. Diffuse tumoral lesions of the chest cavity tissues, focal tumorous lesions of the lung parenchyma, and lymphadenopathy of the mediastinal lymph nodes were found during the autopsy in the first case. The second clinical case demonstrated the massive lymphadenopathy of the mediastinal lymph nodes. Histologically, a diffuse lesion by a monomorphic population of lymphoblasts was revealed in preparations from the soft tissues of the chest wall. The lymphoblasts’ insignificant cytoplasm, with nuclei from round to elliptical shape, infiltrated the chest wall’s soft tissues. It was found immunohistochemically that the blast cells showed reactivity to CD79a, and were mostly negative to CD3. This indicates the development of a large diffuse B-cell lymphoma. The immunohistochemical picture of lymph node necropsies from another cat was somewhat similar. However, it was also characterized by lymphoblasts with eccentrically placed nuclei, increased number of cells with mitotic figures, somewhat intensive CD3 antibodies expression (especially in the paracortical area of lymph nodes), and significant CD79a marker expression.

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Section: Introductionmentioning

confidence: 80%

Pathohistological features of mediastinal lymphoma in domestic cats

Oriekhova

Shchebentovska

2022

Regul. Mech. Biosyst.

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“…Lymphoma is a haemopoietic neoplasm that derives from lymphocytes and usually originates in lymphoid tissues, although this can occur in any tissue of the body. 7,8 Haemopoietic neoplasia accounts for approximately one-third of feline cancers, with lymphoma accounting for 90% of the haemopoietic neoplasia cases in cats. [9][10][11] Several reports have investigated predisposing factors, with strong evidence showing an increased prevalence of lymphoma in feline leukaemia virus (FeLV) positive patients.…”

Section: Discussionmentioning

confidence: 99%

Resolution of HCM phenotype and CHF following CMOP protocol in a cat with large cell lymphoma and suspected cardiac involvement

Herbert¹,

Todd²,

Leeder³

2022

Vet Record Case Reports

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A 10‐year‐old female desexed domestic shorthair cat was diagnosed by the regular veterinarian with large cell splenic lymphoma in June 2020. A splenectomy was performed; however, complications postoperatively and the owner's willingness to pursue chemotherapy resulted in the patient being referred to the oncology department of a local multidisciplinary specialist hospital. At referral, a hypertrophic cardiomyopathy (HCM) phenotype was diagnosed post an episode of dyspnea. The patient was treated with CMOP (cyclophosphamide, mitoxantrone, vincristine and prednisone) chemotherapy, resulting in remission of the lymphoma and the HCM phenotype. Twenty‐one months out from treatment, the patient was still in remission with no evidence of heart disease.

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Section: Introductionmentioning

confidence: 99%

“…Hematopoietic tumors are considered to have the highest incidence among domestic cats [1][2][3][4][5], comprising onethird of all tumors in cats. They can be systemic or multicentric and affect different tissues [5]. Viruses such as the feline leukemia virus (FeLV) [6,7] and the feline immunodeficiency virus (FIV) [8] are among the possible causes for this disease emergence.…”

Section: Introductionmentioning

confidence: 99%

“…It is considered the second most common neoplasia found in the gastrointestinal tract of cats [12]. It affects 50% of the felines diagnosed with lymphoma [5]. This type of neoplasia may manifest itself in two ways: lymphocytic, also called small cells or poorlydifferentiated, and lymphoblastic, also called large cells or highly differentiated, which may extend beyond the gastrointestinal tract, reaching peripheral, thoracic, and bone marrow lymph nodes [13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Treatment of Alimentary Lymphoma in Cat (Felis catus) by Injectable Homeopathy – Case Report

2021

Integr J Vet Biosci

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Primary Cardiac Lymphoma in a Cat

Cited by 6 publications

References 15 publications

Pathohistological features of mediastinal lymphoma in domestic cats

Pathohistological features of mediastinal lymphoma in domestic cats

Resolution of HCM phenotype and CHF following CMOP protocol in a cat with large cell lymphoma and suspected cardiac involvement

Treatment of Alimentary Lymphoma in Cat (Felis catus) by Injectable Homeopathy – Case Report

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