Primary central nervous system lymphoma in neuropsychiatric systemic lupus erythematosus: case-based review

Primary central nervous system lymphoma in a patient treated with mycophenolate mofetil for lupus nephritis

“…Dosing ranged from 500 mg/day to 2 g/day, and median exposure time to MMF was three years. Five out of seven cases were positive for EBV‐encoded RNA in situ hybridization 1,6–9 . In our case, serologic evidence of past infection and histopathological positivity for LMP‐1 strongly suggested an EBV‐associated PCNSL.…”

“…Five out of seven cases were positive for EBV-encoded RNA in situ hybridization. 1,[6][7][8][9] In our case, serologic evidence of past infection and histopathological positivity for LMP-1 strongly suggested an EBV-associated PCNSL.…”

“…Primary central nervous system lymphoma (PCNSL) is a rare hematologic neoplasm limited to the brain, spinal cord, leptomeninges, or eyes, accounting for 1%‐2% of all non‐Hodgkin lymphomas 1,2 . Mycophenolate mofetil (MMF) is one recommended drugs for the treatment of lupus nephritis (LN) 3,4 .…”

“…Primary central nervous system lymphoma (PCNSL) is a rare hematologic neoplasm limited to the brain, spinal cord, leptomeninges, or eyes, accounting for 1%-2% of all non-Hodgkin lymphomas. 1,2 Mycophenolate mofetil (MMF) is one recommended drugs for the treatment of lupus nephritis (LN). 3,4 The evidence regarding its development in patients with systemic lupus erythematosus (SLE) treated with MMF is limited to a few case reports.…”

Primary central nervous system lymphoma in an adolescent with lupus nephritis

“…The relationship between lymphoma and SLE has not been clearly elucidated. It might be a long term exposure to immunosuppressants or persistence of high disease activity [7]. Immunosuppressive agents might lead to lymphoma by direct mutagenesis or by disturbing immune surveillance [2].…”