Primary central nervous system lymphoma revealed by multiple intraventricular mass lesions

Philippart, Marie; Mulquin, Nicolas; Gustin, Thierry; Fervaille, Caroline; London, Frédéric

doi:10.1007/s13760-018-1017-6

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Low-grade PCNSL with homogeneously enhancing intraventricular lesions should be differentiated from other common ventricular neoplasms, such as choroid plexus papilloma, meningioma, subependymoma and metastasis. In addition, differential diagnosis must be made with other types of PCNS lymphoma involved in the ventricles [10, 11]. Although advanced imaging techniques can increase the diagnostic accuracy and help in differentiating PCNSL from other tumours or non-tumour lesions, brain biopsy is required to confirm the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary central nervous system small lymphocytic lymphoma in the bilateral ventricles: two case reports

et al. 2019

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Background Primary central nervous system (CNS) small lymphocytic lymphoma (SLL), as a type of low-grade lymphoma, is extremely rare. The diagnosis of CNS SLL is challenging due to its variable clinical and radiological features, which may overlap with those of diffuse large B-cell lymphoma (DLBCL). Primary CNS SLL differs from DLBCL in that it has an indolent clinical course and a good prognosis. Thus, it is important to distinguish SLL from DLBCL. By reviewing the literature, only two cases of low-grade SLL, primarily located in the CNS and involving the brain parenchyma and dura, have been reported. To our knowledge, primary CNS SLL in the bilateral ventricles has never been reported. Interestingly, the two cases in our report are identical in terms of the clinical presentations, magnetic resonance imaging (MRI) features, pathological results and prognoses. Case presentation Both patients presented with headaches. MRI suggested solid lesions located in the bilateral ventricles that were isointense on T1-weighted images and hypointense on T2-weighted images. After the injection of contrast agent (gadolinium, Gd), the intraventricular lesions were homogeneously enhanced and hyperperfused. CSF cytology revealed malignant cells. Brain biopsy revealed diffuse proliferation of small lymphocytes with positive labelling of B-cell immunomarkers. The primary origin in the CNS was confirmed with no evidence of systemic lymphoma. Two patients were given high doses of methotrexate-based chemotherapy and were free from symptoms and progression for more than 1-year of follow-up. Conclusions The presence of homogeneously enhanced intraventricular MRI lesions should raise the suspicion of primary CNS SLL.

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Section: Discussionmentioning

confidence: 99%

Primary central nervous system small lymphocytic lymphoma in the bilateral ventricles: two case reports

et al. 2019

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“…It is extremely rare that the lesions are confined to the ventricular system, especially the third ventricle. To date, the related clinical and imaging findings regarding the ventricular PCNSL are confined to single case reports and short series (Supplementary Table 1) (1,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Here, we report a case of PCNSL located in the third ventricle, the body, and the posterior horn of the lateral ventricle.…”

Section: Introductionmentioning

confidence: 92%

Case report: Ventricular primary central nervous system lymphoma with partial hypointensity on diffusion-weighted imaging

Xiong

2022

Front. Neurol.

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IntroductionPrimary central nervous system lymphoma (PCNSL) is infrequent and represents 3. 1% of primary brain tumors. And the lesions that are restricted to the ventricular system, particularly the third ventricle, are even rarer. There are few pieces of literature or case reports to date. We report a case of PCNSL with partial hypointense on diffusion-weighted imaging (DWI) located in the lateral and third ventricles. Then we reviewed almost all case reports of ventricular PCNSLs in the last 20 years, discuss the imaging presentation, other ventricular tumors with similar imaging findings, and primary treatment measures.Case presentationA 78-year-old man presented with memory loss and poor responsiveness for one week without obvious precipitating factors. Magnetic resonance imaging (MRI) showed lesions in the third ventricle and left lateral ventricles, which were slightly hypointense on T1-weighted imaging (T1WI), and isointense to slightly hypointense on T2-weighted imaging (T2WI). On DWI, the left lateral ventricular lesion was hyperintense, while the third ventricular lesion was hypointense. After the surgical procedure, the pathology and immunohistochemistry revealed diffuse large B-cell lymphoma (DLBCL).ConclusionsVentricular PCNSL is quite rare, and may be confused with other tumors in the same position. However, PCNSL differs from other central nervous system tumors in that it is primarily treated with chemotherapy and/or radiation therapy. So, it is important to recognize PCNSL and differentiate it from other tumors, considering its implications for management planning.

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Efficacy of endoscopic management of primary central nervous system lymphoma: a multicentric study and literature review

et al. 2022

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Primary central nervous system lymphoma revealed by multiple intraventricular mass lesions

Cited by 3 publications

References 2 publications

Primary central nervous system small lymphocytic lymphoma in the bilateral ventricles: two case reports

Primary central nervous system small lymphocytic lymphoma in the bilateral ventricles: two case reports

Case report: Ventricular primary central nervous system lymphoma with partial hypointensity on diffusion-weighted imaging

Efficacy of endoscopic management of primary central nervous system lymphoma: a multicentric study and literature review

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