Primary Choriocarcinoma of the Kidney in a 49-Year-Old Woman

Mihatsch, Michael J.; Bleisch, Arnold; Six, Paolo; Heitz, Philipp U.

doi:10.1016/s0022-5347(17)60796-1

Cited by 19 publications

(7 citation statements)

References 6 publications

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“…6 Friedman suggested that germ cells are present in apparently ectopic sites in all humans. 13 The notion that ESTs develop by malignant transformation of primordial germ cells is not supported by cases in which malignant tumors occur in the absence of teratomatous elements, especially in the gastrointestinal tract, [14][15][16] kidney, 17 and urinary bladder. 18 Furthermore, since animal experiments have induced EST in the absence of primordial germ cell, it is argued that somatic cells can be induced to differentiate into structures resembling fetal yolk sac.…”

Section: Discussionmentioning

confidence: 99%

Endodermal sinus tumor of the paranasal sinuses

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Endodermal sinus tumor of the paranasal sinuses

et al. 2007

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“…Friedman suggested that germ cells are present in apparently ectopic sites in all humans 13. The notion that ESTs develop by malignant transformation of primordial germ cells is not supported by cases in which malignant tumors occur in the absence of teratomatous elements, especially in the gastroin‐ testinal tract,14–16 kidney,17 and urinary bladder 18. Furthermore, since animal experiments have induced EST in the absence of primordial germ cell, it is argued that somatic cells can be induced to differentiate into structures resembling fetal yolk sac 10.…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyosarcoma: Value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype

Hostein

Andraud-Fregeville

Guillou

et al. 2004

Cancer

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BACKGROUNDIdentification of the alveolar subtype of rhabdomyosarcoma (ARMS) is important, because the poor prognosis associated with this subtype necessitates a modified therapeutic regimen. At present, ARMS diagnoses are made on the basis of histologic findings and the extent of myogenin immunopositivity. Nonetheless, the absence of an alveolar pattern in the solid variant, the low degree of differentiation in certain embryonal rhabdomyosarcomas (ERMS), and the increasing use of microbiopsy samples make the diagnosis of ARMS somewhat difficult. Two specific translocations have been found in ARMS, and fusion transcripts can be detected by reverse transcriptase–polymerase chain reaction (RT‐PCR) analysis of paraffin‐embedded tissue (PET).METHODSTo assess the value of myogenin staining and molecular testing in the diagnosis of rhabdomyosarcoma, the authors examined 109 rhabdomyosarcoma samples (45 ARMS samples and 64 ERMS samples). Real‐time RT‐PCR analysis of PET was performed in all 109 rhabdomyosarcomas, and RT‐PCR analysis of frozen material was performed in 24 cases.RESULTSPAX fusion transcripts were present in 44 cases (39 ARMS and 5 ERMS) and absent in 52 cases (2 ARMS and 50 ERMS). In 13 cases (4 ARMS and 9 ERMS), the results were not interpretable. Results were concordant between paired frozen and fixed tumor samples. All 35 interpretable ERMS samples that contained < 50% myogenin‐positive cells failed to yield detectable PAX fusion transcripts. Of the 61 interpretable tumor samples (41 ARMS and 20 ERMS) that contained > 50% myogenin‐positive cells, 44 (39 ARMS and 5 ERMS) yielded detectable PAX fusion transcripts.CONCLUSIONSThe current study demonstrates that molecular detection of PAX fusion transcripts via real‐time RT‐PCR analysis of PET is a sensitive and specific method for the diagnosis of ARMS and that immunohistochemical analysis of myogenin expression can be used to select cases for such molecular testing. Although RT‐PCR analysis appears not to possess diagnostic value in tumors with < 50% tumor cell immunopositivity, it is strongly recommended for the diagnosis of tumors containing > 50% myogenin‐positive cells. Cancer 2004. © 2004 American Cancer Society.

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“…The tumor usually occurs in the testis [3]. The other sites of the tumor are the mediastinum, retroperitonium, alimentary tract, urinary bladder, liver, kidneys, pineal body and pituitary gland [2][3][4][5][6][7][8][9]. Our case showed no evidence of primary neoplastic lesions in these organs in careful autopsy examination.…”

Section: Discussionmentioning

confidence: 74%

A Rare Case of Primary Pulmonary Choriocarcinoma in a Male: Immunohistochemical Detection for Human Chorionic Gonadotropin, Epidermal Growth Factor (EGF) and EGF-Receptor.

Toda

Inoue²,

Ishino³

et al. 1995

Endocr J

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Abstract.A rare case of primary choriocarcinoma of the lung in a male is described with immunohistochemistry for human chorionic gonadotropin (hCG), epidermal growth factor (EGF) and EGF-receptor.The extragonadal trophoblastic origin of this pulmonary carcinoma was definitely confirmed by an autopsy examination, and hCG-production and hCG-positive staining of the tumor cells. Furthermore, the tumor cells clearly expressed EGF and its receptor which play an important role in the proliferation and differentiation of normal and neoplastic trophoblasts of the uterus. Our present case suggests that EGF may act in an autocrine manner in the tumor cells of primary pulmonary choriocarcinoma.

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Primary Choriocarcinoma of the Kidney in a 49-Year-Old Woman

Cited by 19 publications

References 6 publications

Endodermal sinus tumor of the paranasal sinuses

Endodermal sinus tumor of the paranasal sinuses

Rhabdomyosarcoma: Value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype

A Rare Case of Primary Pulmonary Choriocarcinoma in a Male: Immunohistochemical Detection for Human Chorionic Gonadotropin, Epidermal Growth Factor (EGF) and EGF-Receptor.

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