Primary choriocarcinoma of the vulva

Weiß, Stefan; Amit, Amnon; Schwartz, Mary R.; Kaplan, Alan L.

doi:10.1046/j.1525-1438.2001.01005.x

Cited by 39 publications

(38 citation statements)

References 11 publications

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“…Exman et al (9) hypothesized that polymorphic analysis of tumor DNA was necessary for diagnosis. Rare cases of NGCO have also been reported at multiple locations, including the ovaries (9), lungs (10), urinary bladder (11), stomach (12) and vulva (13). The current patient presented with extra-uterine choriocarcinoma, and the primary symptoms exhibited were pulmonary lesions, bone metastases and skin masses.…”

Section: Discussionmentioning

confidence: 79%

Choriocarcinoma with multiple lung, skull and skin metastases in a postmenopausal female: A case report

Liu

2015

Oncology Letters

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Abstract. Gestational trophoblastic disease with a primary extra-uterine nidus is rare, particularly during the postmenopausal period. The present report outlines a case of high-risk choriocarcinoma (International Federation of Gynecology and Obstetrics stage IV; World Health Organization score 13) in a 68-year-old female exhibiting neoplasm. The choriocarcinoma developed 20 years subsequent to the onset of menopause and 42 years following the patient's final pregnancy, and was associated with multiple metastases to the lungs, skull, neck, lymph nodes and skin. The patient was administered two courses of systemic chemotherapy with tegafur (800 mg) and actinomycin D (200 µg). Local chemotherapy was also administered to the scalp and left flank masses; the masses were injected first with methotrexate, and then with 5-fluorouracil. During chemotherapy, the patient's levels of β-human chorionic gonadotrophin (β-HCG) decreased from 3,171 IU/l to 1,763 IU/l, however by the conclusion of the courses of systemic and local chemotherapy, β-HCG levels had increased to 3,704 IU/l. The patient and their family subsequently elected to end treatment. The patient subsequently succumbed to infection, tumor consumption and organ insufficiency. This study describes the clinical and radiological features, as well as the treatment used for this rare type of choriocarcinoma.

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Section: Discussionmentioning

confidence: 79%

Choriocarcinoma with multiple lung, skull and skin metastases in a postmenopausal female: A case report

Liu

2015

Oncology Letters

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“…As these tumors are rare, treatment recommendations for primary extraovarian, nongestational choriocarcinoma are not available. Weiss et al 11 emphasized that there were two options for the treatment of these tumors. One of them was to treat this type of tumor as a gestational germ cell tumor and then decide whether to initiate single-agent or multi agent chemotherapy.…”

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confidence: 99%

A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman

Park

Kim

et al. 2009

J Gynecol Oncol

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Primary ovarian choriocarcinoma arising from a germ cell is an extremely rare occurrence, especially in postmenopausal women, and the prognosis is poor. Non-gestational choriocarcinoma of the ovary (NGCO) accounts for 0.6% or less of all ovarian neoplasms. It is important to distinguish gestational choriocarcinomas of the ovary (GCO) from other carcinomas because of the poor prognosis of NGCO. We describe a case of NGCO with lung metastasis in a 55 year old woman, which we present together with a brief review of the literature.

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“…Choriocarcinoma is solid trophoblastic tumor developed primarily in the myometrium (Figs 4A to D) or in distant organs and tissues, [10][11][12][13][14][15] usually after the removal of a complete or partial hydatidiform mole and also infrequently after abortion or normal delivery. They are defined as gestational choriocarcinoma or trophoblastic disease (GTD 16 Uterine cervical choriocarcinoma was also experienced.…”

Section: Choriocarcinomamentioning

confidence: 99%

Trophoblastic Diseases

Varga¹,

Honemeyer²,

Maeda³

2012

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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Trophoblastic diseases are mainly hydatidiform mole and choriocarcinoma, where the latter is usually the sequela of molar pregnancy and malignant systemic disease with general metastases destructing various tissues and organs till she die. High level urinary hCG, real-time B-mode and color Doppler imaging detect hydatidiform mole in early gestation, postmolar persistent trophoblastic disease is diagnosed by urinary hCG, and treated by prophylactic chemotherapy against choriocarcinoma. Uterine choriocarcinoma and its metastases are diagnosed by hCG and B-mode, color and power Doppler and 3D images detecting rich tumor blood flow. Most choriocarcinoma was effectively treated by primary chemotherapy with methotrexate, etoposide, etc. Until complete remission where hCG is lower than the cut-off level. Placental site trophoblastic tumor (PSTT) and epitheloid trophoblastic tumor (ETT) were low in hCG level and high in human placental lactogen (hPL), and show rich tumor blood flow in color Doppler ultrsound. Nongestational choriocarcinoma is rare and usually chemotherapy resistant.

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Primary choriocarcinoma of the vulva

Cited by 39 publications

References 11 publications

Choriocarcinoma with multiple lung, skull and skin metastases in a postmenopausal female: A case report

Choriocarcinoma with multiple lung, skull and skin metastases in a postmenopausal female: A case report

A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman

Trophoblastic Diseases

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