Primary chronic interstitial nephritis in Crohn's disease

5-aminosalicylic acids and the risk of renal disease: A large British epidemiologic study☆

“…30 Recently, Izzedine et al reported on 4 patients with Crohn's disease who developed severe interstitial nephritis and were not treated with 5-ASA. 31 Other studies have found that renal tubular proteinuria was related to IBD disease activity. [32][33][34][35] Thomas et al reported that, in a small case series, the incidence of biopsy-proven glomerulonephritis was higher in patients with ulcerative colitis.…”

The Histopathologic Spectrum of Kidney Biopsies in Patients with Inflammatory Bowel Disease

“…However, kidney tubular damage, in the form of proteinuria and enzymuria, has been frequently observed in IBD and is more strongly correlated with disease activity than therapy (41)(42)(43). There have also been several case reports of interstitial nephritis in therapy-naive patients to include the development of kidney failure before or concurrently with the diagnosis of bowel inflammation (44)(45)(46)(47)(48)(49)). This appears to be more common in CD than in UC.…”

Infliximab-Induced Tubulointerstitial Nephritis with Image Findings of Striated Nephrogram in Crohn’s Disease

“…There are several reports of extraintestinal manifestation in the kidney in Crohn's disease. Tubulointerstitial nephritis has been reported in 9 patients, but occurred during follow-up of the bowel disease, and was not associated with drug treatment (Larchet et al 1988;Archimandritis and Weetch 1993;Tovbin et al 2000;Izzedine et al 2002;Marcus et al 2008;Waters et al 2008;Shahrani Muhammad et al 2010). The main mechanisms of extraintestinal manifestation in the kidney are thought to include infectious agents, T-cell-mediated hypersensitivity, circulating bacterial endotoxins, and genetic factors (Colvin et al 2014).…”