Primary Clear Cell Adenocarcinoma of the Peritoneum

J. Maxillofac. Oral Surg.

2011

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Objective To reports ten Japanese surgical cases of verrucous carcinoma (VC) of the oral cavity. Study design The author reviewed histopathology of 10 cases of oral VC. Results Ten cases of oral VC were found in our pathology department in the last 10 years. During the 10 years, a total of 187 cases of oral malignancy were recognized. Therefore, the frequency of VC was 5.3% of all oral malignancies. The patients consisted of six women and four men. The age ranged from 52 to 84 years with a median of 68 years. The locations of VC were buccal mucosa in two cases, gingiva in three cases, hard palate in one case, tongue in three cases, and soft palate in one case. The presenting symptoms were oral discomfort in two cases and tumors in eight cases. All cases underwent surgical resection. Frozen sections were performed in three cases for margin check. Grossly, all cases showed verrucous lesions. The size ranged from 0.8 to 3.2 cm with a median of 1.3 cm. Histologically, tumor cells proliferated with verrucous or papillary features. The tumor cells had acidophilic, ample cytoplasm, and nuclear atypia was minimal. Individual keratinization, koilocytosis, basal cell mild atypia, and squamous pearl formation were recognized in all cases. Three cases showed microinvasion. One case had focal ordinary squamous cell carcinoma within the VC. Epithelial dysplasia in the mucosa was recognized in the vicinity of VC in two cases. One case showed multiple tumors of VC; the number was five. Lymphocytic infiltration in the dermis was recognized in seven cases. Immunohistochemically, p53 protein was positive in all the ten cases. Its location was accentuated near the basal cells and microinvasive parts. Ki-67 positive cells were also seen mainly in the basal cells and in the microinvasive areas, and the KI-67 labeling index ranged from 12 to 21%. Two patients recurred, and additional operations were performed. None show metastatic lesions. One patient died of other disease, and nine patients are now alive without tumors. Conclusion Clinicopathologic features of ten cases of oral VC were described.

Section: Methodsmentioning

confidence: 99%

Verrucous Carcinoma of the Oral Cavity: A Histopathologic Study of 10 Japanese Cases

J. Maxillofac. Oral Surg.

2011

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“…[10,11] In this respect, it is very interesting that primary carcinoma indistinguishable from serous tumors of ovary can arise from mesothelium. [12] The present case clinically presented with signs and symptom of right tubal pregnancy. The data of elevated serum hCG supported the diagnosis of tubal pregnancy.…”

Section: Discussionmentioning

confidence: 69%

Serous surface papillary cystadenoma of fallopian tube clinically presenting with ectopic pregnancy

2016

CRCP

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Herein reported is the rare case of serous surface papillary cystadenoma (SSPC) of fallopian tube who presented with signs and symptoms of ectopic pregnancy. A 31-year-old woman presented with abdominal pain and elevation of serum human chorionic gonadotropin (hCG) (2,530 IU/L). Pelvic ultrasound examination suggested a rupture of right tubal pregnancy. Emergency laparotomy was performed, and right fallopian tube was resected. Pathologically, the fallopian tube was totally replaced by SSPC, but no evidence for pregnancy (chorionic villi, fetus, decidua, amnion, and cord) was seen. The SSPC was unilocular, and was surrounded by multiple papillary proliferations of serous cells with fibro-vascular cores, which were recognized both in the surface areas and in the intracystic inner aspects. The tumor cells of the SSPC were negative for hCG. After operation hCG returned to the normal range, and the patient was recovered with no complications. A rare case of SSPC of fallopian tube with pseudo-manifestations of ectopic pregnancy is reported. The raised serum hCG and its return to the normal ranges after the tube resection are completely unclear and enigma.

“…7). An immunohistochemical study was performed with the use of Dako Envision method, as previously reported [10,11]. The antibodies were HPV (polyclonal, Dako), p53 protein (DO7, Dako), and Ki-67 (MIB1, Dako).…”

Section: Case Reportmentioning

confidence: 99%

Multiple Verrucous Carcinomas of the Oral Cavity

J. Maxillofac. Oral Surg.

2014

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The author herein reports a case of multiple verrucous carcinomas (VCs) of the left lower gingiva. A 78-year-old man was admitted to our hospital because of gingival tumor. A biopsy revealed severe dysplasia. Surgical resection was performed. Grossly, there were three verrucous lesions (25, 20, 10 mm) in the left lower gingiva. Histologically, 2 tumors (4, 2 mm) were found in addition to the grossly visible 3 tumors. All the 5 tumors were VCs. The tumors showed verrucous and papillary proliferation of squamous epithelium with little cellular atypia. No invasive features were recognized. The dermis showed lymphocytic infiltration. The surrounding mucosa showed many broad foci of squamous cell carcinoma in situ and severe dysplasia (high grade intraepithelial neoplasm). Gradual merges between the VCs and squamous cell carcinoma in situ or severe dysplasia were frequently recognized. Immunohistochemically, the VC tumor cells and squamous lesions were negative for human papilloma virus antigens. P53 protein was expressed in all the VCs and squamous epithelial lesions: it was accentuated in the basal and suprabasal cells of VC. Ki-67 antigen was also expressed in the 5 VCs and in the squamous lesion, and Ki-67 labeling index ranged from 8 to 16 % in VC and from 37 to 62 % in the squamous lesions. These data support the multicentric nature of VC and that the severe dysplasiacarcinoma in situ sequence have been proposed in the etiology of VC.