Primary Cutaneous Cryptococcosis due to <b><i>Cryptococcus neoformans</i></b> in an Immunocompetent Host Treated with Itraconazole and Drainage: Case Report and Review of the Literature

Abstract

&lt;i&gt;Cryptococcus neoformans&lt;/i&gt; is an opportunistic germ, usually causing infections in immunocompromised patients. The main sources of infection with &lt;i&gt;C. neoformans&lt;/i&gt; are excrement from birds, decomposing wood, fruit, and vegetables. Primary cutaneous cryptococcosis (PCC) is a clinical entity, differing from secondary cutaneous cryptococcosis and systematic infection. We report the case of an immunocompetent 60-year-old woman with PCC due to &lt;i&gt;C. neoformans&lt;/i&gt; in her right thumb. She reported an accidental injury caused by a rose thorn while she was gardening. Clinical examination showed the presence of an erythematous ulcerated nodule with elevated borders, suppuration, and central necrosis. Skin histology examination showed cutaneous and subcutaneous fibrinoid necrosis with bleeding, abscess, neutrophil-rich cellular infiltration, and the presence of PAS-, Grocott- and mucin-positive spores. The mycological culture showed milky and creamy colonies of &lt;i&gt;C. neoformans&lt;/i&gt; after 3 days. As there was no previous history of pulmonary cryptococcosis, we diagnosed PPC. We treated the patient surgically with accurate debridement of nonvital tissues in the right thumb. In addition, we started itraconazole treatment 100 mg twice daily for 6 months, which led to rapid clinical improvement without relapse. PCC is a rare infection that can present with quite unspecific clinical pictures including acneiform lesions, purpura, vesicles, nodules, abscesses, ulcers, granulomas, pustules, draining sinuses, and cellulitis. Prolonged systemic antifungal therapy is necessary in order to get a healing result without relapse. We summarize all the cases of PCC in immunocompetent patients published so far in the literature.

Primary Cutaneous Cryptococcosis in an Elderly Patient: A Case Report and Review of Literature

“…2,10–12 Combined surgical excision with systemic antifungal drug administration has demonstrated efficacy in patients with limited skin damage. 13 In this case, the rash completely subsided after 3 months of itraconazole treatment, indicating that itraconazole exhibits a favorable therapeutic effect on C. neoformans –induced PCC.…”

Recurrent Fatal Cryptococcal Meningitis in a Patient with Liver Transplant: A Case Report and Review of Literature

“…Delayed diagnosis and inadequate treatment can result in lung and CNS involvement (12). Noguchi et al recommended regular monitoring of organ transplant recipients by the transplant skin clinic before and after transplantation and throughout their lifetime (13).…”

Primary Cutaneous Cryptococcosis in an Immunocompetent Patient: Diagnostic Workflow and Choice of Treatment

“…The majority of PCC cases described in literature have been treated with oral fluconazole or itraconazole alone for an average period of 3-6 months [11,12]. In some cases, therapy was given for 3 months but was accompanied by surgical debridement of the lesion [13,14]. In other cases, the drainage alone of the cutaneous lesions was curative [15].…”