Primary cutaneous diffuse large B cell lymphoma relapsed solely as a huge lung tumor mimicking a primary pulmonary lymphoma

Abstract

Primary cutaneous large B cell lymphoma, leg type (PCLBCL-leg) has recently been identified and recognized as a specific entity. Patients with PCLBCL-leg have a higher relapse rate and a poorer prognosis than the other types of primary cutaneous B cell lymphomas, and disease relapse is confined to the skin in the majority of cases with rare exclusive extracutaneous progression. The late occurrence of lymphoma in patients with a prior history of lymphoma may represent a relapse/progression or a distinct tumor unrelated to the original one. The distinction is of important clinical and therapeutic implications. Here, we report the case of a 90-year-old lady with a history of PCLBCL-leg in complete remission after radiotherapy that developed a huge, solitary pulmonary lymphoma without lymphadenopathy 14 months later. The latter was initially considered as stage IE primary pulmonary lymphoma and was treated with combination chemotherapy resulting in complete remission. Retrospective pathologic review and B cell clonality study revealed that the pulmonary tumor was a diffuse large B cell lymphoma of the same clonal origin as the PCLBCL-leg. This case is unique in the exclusive pulmonary relapse and illustrates the importance of expert pathological review and molecular study in the management of lymphoma patients with unusual clinical features.

Rezidiv eines systemischen, diffus-großzelligen B-Zell-Lymphoms unter dem Bild eines primär kutanen, diffus-großzelligen B-Zell-Lymphoms, Leg Type

“…Aufgrund des häufig vorkommenden extrakutanen Befalls ist die Prognose mit einer 5-Jahres-Überlebensrate von 55 % erheblich schlechter als bei den indolenten kutanen B-Zell-Lymphomen [5]. In der aktuellen WHO-EORTC-Lymphom-Klassifikation der kutanen Lymphome werden neben dem PCDLBL, LT, auch noch andere Formen des primär kutanen, diffus-großzelligen B-Zell-Lymphoms aufgeführt (PCDLBL, other) [1,2,6].…”