Primary cutaneous extraskeletal Ewing's sarcoma/PNET: possibility of better prognosis than deep ES/PNET

Omori, Mamiko; Ueno, Mitsuhiko; Ogawa, Masakata; Nagano, Tohru

doi:10.1684/ejd.2013.2247

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…Similarly, the most common sites of endoceliac EES in our research were the kidneys and retroperitoneum. Omori et al reported that EES arising in cutaneous or subcutaneous tissue was associated with favourable prognosis compared to deep EES ( 19 ). Further, the prognosis of patients with EES arising from the abdomen is reported to be poorer than that of patients with EES arising from other sites ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Extraskeletal Ewing’s sarcoma: outcomes and CT features of endoceliac lesions

Chen¹,

Jiao²,

Liu³

et al. 2021

Transl Cancer Res TCR

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Background: Extraskeletal Ewing's sarcoma (EES) is one kind of rare malignant tumour which is always misdiagnosed preoperatively, especially for lesions located at endoceliac sites. This study analyse the clinicopathological features and outcomes of EES patients. The basic imaging characteristics of endoceliac lesions are also summarized.Methods: This study involved EES patients admitted to our centre between January 2000 and January 2020. Clinical data from patients with EES (n=25) and computed tomography (CT) features from endoceliac EES patients with available CT data (n=8) were retrospectively reviewed. Results:The sample comprised 18 males and 7 females with a median age of 30 years (range, 1-72 years).Seven patients had EES originating from surface sites and 18 had EES originating from endoceliac sites.The median tumour size was 8.0 cm (range, 2.5-17.0 cm). In total, 20% of patients had distant metastasis at diagnosis. In the univariate analyses, tumour size >8 cm, non-surgical treatment, and regional lymph nodes metastasis were risk factors for poor prognosis of EES. In the multivariate analysis, patients with larger tumour size and regional lymph node metastasis were independent predictors of overall survival (OS).Endoceliac EES cases frequently exhibited lobulated contour (87.5%), absence of calcification (75%), severe necrosis or cystic degeneration (75%), heterogeneous enhancement (100%), moderate enhancement (75%), ill-defined borderline (62.5%), and organ invasion (75%). Half of the patients with endoceliac EES had CT features of lymphadenopathy.Conclusions: Comprehensive understanding of the clinicopathological and imaging features of EES is beneficial for diagnosis, development of therapeutic strategies, and accurate prediction of prognosis for this rare malignant tumour.

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Section: Discussionmentioning

confidence: 99%

Extraskeletal Ewing’s sarcoma: outcomes and CT features of endoceliac lesions

Chen¹,

Jiao²,

Liu³

et al. 2021

Transl Cancer Res TCR

View full text Add to dashboard Cite

show abstract

“…Similarly, the most common sites of endoceliac EES in our research were the kidneys and retroperitoneum. Mamiko et al reported that EES arising in cutaneous or subcutaneous tissue was associated with favourable prognosis compared to deep EES [24]. Further, the prognosis of patients with EES arising from the abdomen is reported to be poorer than that of patients with EES arising from other sites [25].…”

Section: Discussionmentioning

confidence: 99%

Extraskeletal Ewing’s sarcoma: outcomes and CT features of endoceliac lesions

Chen

Yang

Liu

et al. 2020

Preprint

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Background To analyse the clinicopathological features and outcomes of patients with extraskeletal Ewing’s sarcoma (EES). The basic imaging characteristics of endoceliac lesions, which are always misdiagnosed preoperatively, are also summarised.Methods This study involved EES patients admitted to our centre between January 2000 and January 2020. Clinical data from patients with EES (n = 25) and computed tomography (CT) data from patients with endoceliac lesions (n = 8) were retrospectively reviewed.Results The sample comprised 18 males and 7 females with a median age of 30 years (range 1–72 years). Seven patients had EES originating from surface sites and 18 had EES originating from endoceliac sites. The median tumour size was 8.0 cm (range 2.5–17.0 cm). In total, 20% of patients had distant metastasis at diagnosis. In the univariate analyses, tumour size > 8 cm, undergoing surgery, and regional lymph nodes metastasis were risk factors for poor prognosis of EES. In the multivariate analysis, patients undergoing surgery and regional lymph node metastasis were independent predictors of overall survival (OS). Endoceliac EES cases frequently exhibited lobulated contour (87.5%), absence of calcification (75%), severe necrosis or cystic degeneration (75%), heterogeneous enhancement (100%), moderate enhancement (75%), ill-defined borderline (62.5%), and organ invasion (75%). Half of the patients with endoceliac EES had CT features of lymphadenopathy.Conclusions Comprehensive understanding of the clinicopathological and imaging features of EES is beneficial for diagnosis, development of therapeutic strategies, and accurate prediction of prognosis for this rare malignant tumour. The results suggest that evaluation of the status of regional lymph nodes is important for the treatment of EES.

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“…Most patients undergo combined total resection and chemotherapy. Excessive chemotherapy should be avoided in patients with ESFT in the skin if complete resection of the tumor is possible 4 ) . Our patient underwent no further treatment because complete resection of the tumor was obtained by RAPN with negative surgical margins.…”

Section: Discussionmentioning

confidence: 99%

A case of Ewing sarcoma family tumor of the kidney treated with robotic-assisted partial nephrectomy

Suzuki

Kubota

Murata

et al. 2019

Urology Case Reports

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Ewing sarcoma family tumors (ESFTs) of the kidney represents less than 1% of all renal tumors. A 45-year-old Japanese woman presented with right abdominal pain. Contrast-enhanced computed tomography showed a 12 × 8-cm right cystic renal mass. The mass was diagnosed as cystic renal cell carcinoma (RCC) and right partial nephrectomy was performed. Immunohistochemical studies showed that the tumor was positive for CD99 (membranous staining in tumoral cells), indicating ESFT. The patient is doing well without further therapy after 1 year of follow-up. To our knowledge, this is the first report of renal ESFT mimicking cystic RCC on diagnostic imaging.

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Primary cutaneous extraskeletal Ewing's sarcoma/PNET: possibility of better prognosis than deep ES/PNET

Cited by 5 publications

References 6 publications

Extraskeletal Ewing’s sarcoma: outcomes and CT features of endoceliac lesions

Extraskeletal Ewing’s sarcoma: outcomes and CT features of endoceliac lesions

Extraskeletal Ewing’s sarcoma: outcomes and CT features of endoceliac lesions

A case of Ewing sarcoma family tumor of the kidney treated with robotic-assisted partial nephrectomy

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