Primary Cutaneous Follicle Centre Lymphoma with Hodgkin and Reed-Sternberg Like Cells: A Case Report and Review of the Literature

Reed–Sternberg cells (RSCs) are hallmarks of classic Hodgkin lymphoma (cHL). However, cells with a similar morphology and immunophenotype, so-called Reed–Sternberg-like cells (RSLCs), are occasionally seen in both B cell and T cell non-Hodgkin Lymphomas (NHLs). In NHLs, RSLCs are usually present as scattered elements or in small clusters, and the typical background microenviroment of cHL is usually absent. Nevertheless, in NHLs, the phenotype of RSLCs is very similar to typical RSCs, staining positive for CD30 and EBV, and often for B cell lineage markers, and negative for CD45/LCA. Due to different therapeutic approaches and prognostication, it is mandatory to distinguish between cHL and NHLs. Herein, NHL types in which RSLCs can be detected along with clinicopathological correlation are described. Moreover, the main helpful clues in the differential diagnosis with cHL are summarized.

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“…Isolated RSLCs are described in PCFCL, but their significance has not been well investigated yet [66,67] (Supplementary Table S3).…”

Section: Histological Findings and Immunophenotypementioning

confidence: 99%

“…First of all, a skin-limited disease is strongly suggestive for PCFCL and very unusual in cHL. When present, the RSLCs are CD45/LCA+ and coexpress CD30, CD20 (very strongly), PAX5, BCL2 CD79α, BCL6, and MUM1/IRF4; CD15 and LMP1 are negative [66] (Supplementary Table S3).…”

Section: Clues For Differential Diagnosis With Chlmentioning

confidence: 99%

Hodgkin Reed–Sternberg-Like Cells in Non-Hodgkin Lymphoma

et al. 2020

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“…Among malignancies, CD30-positive T-cells typically characterize lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (cALCL) [ 1 , 36 ], whereas in B-cell neoplasms CD30-positive cells are less common, occurring in the setting of iatrogenic immunosuppression (i.e., mucocutaneous ulcers) [ 1 , 37 ], and in primary cutaneous diffuse large B-cell lymphomas (DLBCL) [ 38 ]. CD30 expression has also been reported in a variable number of neoplastic cells of primary cutaneous follicle center lymphoma (PCFCL) and of primary cutaneous marginal zone lymphoma (PCMZL) [ 14 , 15 , 39 , 40 , 41 , 42 ], with rare cases describing a Hodgkin and Reed–Sternberg (H/RS)-like morphology [ 26 , 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells

et al. 2022

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The spectrum of cutaneous CD30-positive lymphoproliferative disorders encompasses both inflammatory and neoplastic conditions. CD30+ Hodgkin and Reed–Sternberg-like cells have been occasionally reported in primary cutaneous marginal zone lymphoma, where they are thought to represent a side neoplastic component within a dominant background of lymphomatous small B cells. Herein, we describe the histological and molecular findings of three cases of primary cutaneous marginal zone lymphomas with CD30+ H/RS cells, in which next-generation sequencing analysis revealed the clonal population to consist in less than 5% of the cutaneous B-cell infiltrate, providing a thought-provoking focus on a possible main role for CD30+ cells in primary cutaneous marginal zone lymphoproliferations.

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“…The loss of one or more T‐cell markers in these cells suggests the possibility of a dedifferentiation phenomenon. Rare examples of HRS‐like cells in primary cutaneous follicle center lymphoma have in some cases been positive for CD30 and CD15, but also positive for bcl‐6, CD20, and CD45 5,6 . In a series of 13 patients with PCMZL and >10% CD30+ large cells, the large cells were positive for CD20, PAX5, and bcl‐2, and most (12/13) cases were negative for CD15 7 .…”

Section: Figurementioning

confidence: 99%