Primary cutaneous leiomysarcoma

Agale, Shubhangi Vinayak; Grover, Sumit; Zode, Rahul; Hande, S. T.

doi:10.4103/0019-5154.91839

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…When cutaneous, the tumour arises from erector Pilli muscle. When it is subcutaneous in origin it is thought to arise from small to medium sized blood vessel wall, [1][2][3][4][5] as observed in the present case. Although most tumour present as a subcutaneous nodule in the extremities, usually measuring 30 mm or less in diameter in the reported cases.…”

Section: Pathological Findingssupporting

confidence: 57%

“…Wide local excision with 3 to 5 cm surgical margin, has been recommended depending on the size of the tumour and recurrent presentation of tumour, is the primary treatment for the cutaneous leiomyosarcoma. [3][4][5][6][7] Factors correlated with the adverse prognosis with subcutaneous leiomyosarcoma include tumor size (>5cm), high mitotic rate, presence of necrosis, deep seated tumours with fascial involvement, and intratumoral vascular invasion. [1] Adverse prognostic factors present in our case were: giant size, high mitotic rate and deep seated tumour.…”

Section: Pathological Findingsmentioning

confidence: 99%

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Giant Subcutaneous Leiomyosarcoma at Knee Joint:Malignant Tumour at Rare Site

Kumar

Bhadani

Saxena

et al. 2016

International Journal of Medical and Dental Sciences

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Section: Pathological Findingssupporting

confidence: 57%

Section: Pathological Findingsmentioning

confidence: 99%

Giant Subcutaneous Leiomyosarcoma at Knee Joint:Malignant Tumour at Rare Site

Kumar

Bhadani

Saxena

et al. 2016

International Journal of Medical and Dental Sciences

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“…Marjolin's ulcer has a very short recurrence time [28,29]. However, recurrence rates in our study did not show any statistical significance.…”

Section: Resultsmentioning

confidence: 52%

Twenty-Seven Cases of Marjolins Ulcer; An Institutional Experience on Diagnosis, Treatment and Outcomes

BR,

Shankar,

Narayanan

et al. 2024

Asian Pac J Cancer Biol

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Purpose: Marjolins ulcer is a malignant transformation that arises from chronic ulcers or previously traumatized scar that occur usually after burns. To study the clinicopathological characteristics and treatment outcomes of Marjolins ulcer at our institute. Materials and methods: Retrospective analysis of all Marjolins ulcer patients presented to our department from 2018 to 2021 was done. A total of 27 patients of all age groups were included in the study. All the information regarding the diagnosis, treatment and outcome details were collected and analysed.Results: Most of the patients were in the 5th decade of life with an overall male preponderance. The most common cause for Marjolin ulcer was Burns Scar. The mean latency period for the development of Marjolins ulcer was 11 years. Squamous cell carcinoma was the most common histological subtype. 18.5% patients received Adjuvant radiotherapy. At the median follow up of 14 months, one patient presented with locoregional relapse.Conclusion: Chronic non-ulcers that do not respond to treatment should be carefully examined by multidisciplinary team for malignant transformation. Surgery is the mainstay of treatment and Adjuvant Radiotherapy should be considered in high-risk cases to reduce locoregional recurrence. Tumour size and nodal involvement are the main predictors of locoregional relapse.

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“…Marjolin's ulcer has a very short recurrence time [32,33]. However, recurrence rates in our study did not show any statistical significance.…”

Section: Discussionmentioning

confidence: 52%

Marjolins Ulcer: Clinicopathological Profile and Treatment Patterns

Kumar,

Narayanan,

Ganesh

et al. 2023

J. Anal. Oncol.

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Purpose: Marjolins ulcer is a malignant transformation arising from chronic ulcers or previously traumatized scars that occur usually after burns. This article aims to study the clinicopathological profile and treatment patterns of Marjolins ulcer. Materials and Methods: Retrospective analysis of all Marjolins ulcer patients presented to Vydehi Cancer Centre from 2018 to 2021 was done. A total of 27 patients of all age groups were included in the study. All information regarding detailed history, clinical examination, treatment details were retrospectively collected and analysed. Results: Most of the patients were in the 5th decade of life with an overall male preponderance. The most common cause for Marjolins ulcer was Burns scars followed by Trauma. Lower extremities were found to be the most predominant site. The mean latency period for the development of Marjolins ulcer was 11 years. Squamous cell carcinoma was the most common histological subtype, Adjuvant Radiotherapy was given to the patients with high-risk features. Conclusion: Chronic non-healing ulcers that do not respond to treatment should be carefully examined for malignant transformation. Surgery is the mainstay of treatment and Adjuvant Radiotherapy should be considered in high-risk cases to reduce locoregional recurrence.

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Primary cutaneous leiomysarcoma

Cited by 8 publications

References 6 publications

Giant Subcutaneous Leiomyosarcoma at Knee Joint:Malignant Tumour at Rare Site

Giant Subcutaneous Leiomyosarcoma at Knee Joint:Malignant Tumour at Rare Site

Twenty-Seven Cases of Marjolins Ulcer; An Institutional Experience on Diagnosis, Treatment and Outcomes

Marjolins Ulcer: Clinicopathological Profile and Treatment Patterns

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