Primary cutaneous malignant melanoma and its precursor lesions: Diagnostic and therapeutic overview

Kanzler, Matthew H.; Mraz-Gernhard, Serena

doi:10.1067/mjd.2001.116239

Cited by 92 publications

(63 citation statements)

References 107 publications

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“…22,29 Recent studies distinguish between common nevi and atypical (dysplastic) nevi as important risk markers and lesional steps in melanocytic tumor progression. 2,3,30 A limitation of these studies is the lack of a consistent definition of nevi, which is related to the existing controversy surrounding the clinical and histologic definitions of common and atypical nevi. 31 An improved understanding of the natural history of nevi at the subsurface (dermoscopic) level may generate new biologic hypotheses regarding the evolution of nevi.…”

Section: T He Incidence and Mortal-mentioning

confidence: 99%

The Framingham School Nevus Study

et al. 2004

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Section: T He Incidence and Mortal-mentioning

confidence: 99%

The Framingham School Nevus Study

et al. 2004

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“…Die Anzahl benigner Nävi erwies sich als bester prädikativer Parameter, wobei das relative Melanomrisiko für Patienten mit 50 oder mehr Nävi bei 14,9 lag. Einen Erklärungsversuch für diese epidemiologischen Zusammenhänge unternehmen Kanzler und Mraz-Gernhard [15], indem sie folgende 3 Mechanismen aufführen:…”

Section: Epidemiologie Und Assoziation Mit Melanomenunclassified

Dysplastischer melanozyt�rer N�vus

2003

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Today, 20 years after Clark and Elder postulated their tumor progression model of melanocytic lesions from common nevi to melanoma, there are still controversies surrounding this subject. Despite modem molecular biological developments, a consensus about the question, if the dysplastic nevus should be considered as a separate entity, melanoma precursor or just represent a diagnostic dilemma, still seems to be impossible. In addition, since the term melanocytic dysplasia is not precisely defined with regard to all diagnostic methods (clinical morphology, dermatoscopy, dermatopathology, molecular biology), there is considerable confusion. The question remains if a quite arbitrary classification of melanocytic lesions such as dysplastic nevus is useful at all. In daily practice, dermatologists should be aware of the fact that each suspicious melanocytic lesion could represent an early malignant neoplasia, regardless whether it is formally named dysplastic nevus or initial malignant melanoma. We conclude that solid dermatological experience plus novel tools of documentation represent the key factor to minimize patients' risk.

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“…Physicians without dermatological [24] training could not recognize minimal alterations of the shape and of the colour in early-stage melanoma. The amelanotic variant of melanoma may present as pink or red lesion, mimicking other benign lesions (pyogenic granulomas, angiomas).…”

Section: Search For the Evidencementioning

confidence: 99%

“…The amelanotic variant of melanoma may present as pink or red lesion, mimicking other benign lesions (pyogenic granulomas, angiomas). Expert dermatologists [24] trained in the use of specific non-invasive techniques (epilumi nescence microscopy) can improve their diagnostic accuracy of melanoma from about 65%, using the naked eye, to approximately 80% with the benefit of epiluminescence microscopy.…”

Section: Search For the Evidencementioning

confidence: 99%

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Malignant Melanoma in a Candidate for Heart Transplantation

Tessari¹,

Forni

Naldi

et al. 2005

Dermatology

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A superficial spreading melanoma (Breslow thickness 0.4 mm) was diagnosed in a 65-year-old candidate for heart transplantation due to refractory end stage heart failure. After extensive review of the literature (USA and Europe), no clear guidelines about the management of candidates for transplantation with a previous diagnosis of melanoma were found. As this patient had a 5-year probability of survival higher than 95% and heart transplantation was necessary for saving his life, the final decision was to perform the transplantation. Unfortunately, the patient died of heart failure before a suitable heart became available. This case stresses the need for early and continuous dermatological evaluation of all candidates for solid organ transplantation. Clear guidelines for screening of skin cancer before transplantation are needed.

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Primary cutaneous malignant melanoma and its precursor lesions: Diagnostic and therapeutic overview

Cited by 92 publications

References 107 publications

The Framingham School Nevus Study

The Framingham School Nevus Study

Dysplastischer melanozyt�rer N�vus

Malignant Melanoma in a Candidate for Heart Transplantation

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