Primary cutaneous plasmacytoma in an HIV‐positive patient

Multiple cutaneous nodules on the abdomen of an immunosuppressed patient

“…Moreover, they can be classified into primary or secondary to tumor spread from MM or from primary EMP of other tissues. 1,2 In our case, the patient was diagnosed with a secondary cutaneous plasmacytoma in the setting of an established diagnosis of MM. Cutaneous involvement in patients with MM occurs in less than 2% of the cases and is generally associated with advanced stages of the disease, being therefore considered a bad prognostic sign.…”

“…Extramedullary plasmacytomas (EMPs) occur outside the bone marrow, a characteristic that distinguishes them from the more common medullary plasmacytomas. Moreover, they can be classified into primary or secondary to tumor spread from MM or from primary EMP of other tissues 1,2 . In our case, the patient was diagnosed with a secondary cutaneous plasmacytoma in the setting of an established diagnosis of MM.…”

“…Immature plasma cells can be distinguished from other malignancies by the presence of basophilic cytoplasm and coarse chromatin. Immunostaining generally shows positivity for CD138, variable positivity for CD38 and CD79A, and negativity for CD19 and CD20 staining 1,6 . It also reveals monotypic light chains kappa or lambda.…”

“…Immunostaining generally shows positivity for CD138, variable positivity for CD38 and CD79A, and negativity for CD19 and CD20 staining. 1,6 It also reveals monotypic light chains kappa or lambda.…”

Primary Cutaneous Plasmacytoma Treated with Palliative Radiotherapy: A Case Report and Literature Review

“…Otherwise, it would be classified as MM. Pathogenesis in some PCPs has been associated with immunosuppression and viral infections 7 . Clinically, cutaneous plasmacytomas manifests as indurated flesh colored, erythematous, or violaceous nodules or plaques and can be found anywhere on the body 5,7 .…”