Primary cutaneous zygomycosis due to <i>Mucor circinelloides</i>

Chandra, Suresh; Woodgyer, Alan

doi:10.1046/j.1440-0960.2002.00550.x

Cited by 31 publications

(33 citation statements)

References 20 publications

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“…Although Mucor species have been associated with a variety of invasive diseases, primary cutaneous zygomycosis has rarely been reported (16). Three cases of this disease caused by M. circinelloides are described in the literature (2,7,26). In these cases, patients were females ranging in age from 23 to 60 years, and all were known or suspected to have been exposed following trauma of either the left forearm (2), the chest (7), or the right hand (26).…”

Section: Discussionmentioning

confidence: 99%

“…The mortality rate for rhinocerebral zygomycosis in immunocompromised patients has been shown to be Ͼ80%, even when treated; however, primary cutaneous disease has responded more favorably to therapy (2,7,17). Surgery alone was successful in one case (2), and AMB therapy alone was successful in another (7).…”

Section: Discussionmentioning

confidence: 99%

“…Surgery alone was successful in one case (2), and AMB therapy alone was successful in another (7). Therapy with liposomal AMB together with surgical debridement was effective in treating our patient.…”

Section: Discussionmentioning

confidence: 99%

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Mucor circinelloides Was Identified by Molecular Methods as a Cause of Primary Cutaneous Zygomycosis

Iwen¹,

Sigler

Noel³

et al. 2007

J Clin Microbiol

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A case of primary cutaneous zygomycosis caused by Mucor circinelloides is described. Histopathology showed typical hyphae along with chlamydospores. The isolate was identified by molecular and phenotypic methods. The utility of sequence analysis of the internal transcribed spacer region is highlighted; however, further studies are needed to assess species genetic heterogeneity. CASE REPORTA 90-year-old male presented to his primary-care physician with fever, fatigue, and lower-right-leg cellulitis following trauma to the leg. The trauma, which occurred about 1 month prior to presentation, was described by the patient as being "struck by a shrub branch while trimming brush." He had a 2-year history of progressive pancytopenia subsequently diagnosed as myelodysplastic syndrome (MDS) and a 20-year history of diabetes mellitus type II controlled by insulin injections.On physical examination, the temperature was 38°C, and laboratory examination showed pancytopenia with an absolute neutrophil count of 1.0 ϫ 10 3 per mm 3 (normal range, 1.3 ϫ 10 3 to 7.5 ϫ 10 3 per mm 3 ) and hyperglycemia with a serum glucose level of 525 mg per dl (normal range, 70 to 125 mg per dl). He was hospitalized at the Nebraska Medical Center and started on filgrastim (Neupogen; Amgen, Inc., Thousand Oaks, CA) to improve neutropenia and on insulin to control the serum glucose level. Intravenous ceftriaxone and ciprofloxacin were given for the lower-right-leg skin/soft tissue infection. The patient was discharged on day 7 post-primary admission (PPA) with improvement of the leg cellulitis.A follow-up exam on day 14 PPA showed progression of the leg wound, now with a black eschar developing. The patient was readmitted to the hospital with neutropenia (absolute neutrophil cell count, 0.9 ϫ 10 3 per mm 3 ) and hyperglycemia (serum glucose level, 1,160 mg per dl). He was taken to the operating room for debridement of the wound, and tissue was submitted to the hospital clinical microbiology laboratory for bacterial and fungal cultures. The results of a histopathological examination of this tissue were reported as "hemorrhage and extensive necrosis, focal formation of granulation tissue, and numerous invasive fungal organisms (septate hyphae and thick-walled yeast forms)" (Fig. 1). Based on a diagnosis of an invasive fungal (mold) infection, liposomal amphotericin B (AMB) at 5 mg per kg of body weight per day (Abelcet; ENZON Pharmaceuticals, Piscataway, NJ) was begun (day 16 PPA). A fungus grew within 4 days on Sabouraud dextrose (Emmons) agar (Remel Labs, Lenexa, KS) but did not grow on Mycobiotic agar (Remel Labs) after incubation at 30°C. The isolate, which was morphologically identified as a Mucor species, was subsequently sent to the Molecular Mycology Laboratory located at the University of Nebraska Medical Center (UNMC) for species identification. A DNA sequence of the isolate obtained from the internal transcribed spacer (ITS) regions of the rRNA gene was submitted for a BLAST search of the GenBank database (National Center for Biotechnology...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mucor circinelloides Was Identified by Molecular Methods as a Cause of Primary Cutaneous Zygomycosis

Iwen¹,

Sigler

Noel³

et al. 2007

J Clin Microbiol

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“…La enfermedad se caracteriza por la rápida invasión de tejidos y estructuras vasculares con las consiguientes vasculitis y trombosis que conducen a infartos y necrosis tisular (2,3,5,7,12,14,15,22,24,25,27,28,31,32,38). Típicamente, la infección implica el área rhino-facial-craneal, los pulmones, el tracto gastrointestinal, la piel, y menos comúnmente otros sistemas de órganos (21,22).…”

Section: Zygomycosis Is An Infrequent Infection Caused By Opportunistunclassified

“…Por el contrario, en el paciente inmunocomprometido las lesiones, rojas e induradas, progresan formando costras negras que, al desprenderse, dejan úlceras grandes. La preferencia angioinvasiva de los zygomycetes, con la consecuente diseminación por debajo de las estructuras cutáneas, culmina con la necrosis rápida y progresiva no sólo de los tejidos cutáneos y subcutáneos, sino también de la grasa, músculos, tendones, el hueso adyacente y seguir un curso fulminante (3,12,15,23,26,30,31).…”

Section: Zygomycosis Is An Infrequent Infection Caused By Opportunistunclassified

ZIGOMICOSIS CUTANEA PRIMARIA POR Rhyzopus oryzae EN UNA NIÑA CON LEUCEMIA LINFOBLASTICA AGUDA TIPO B

et al. 2008

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Systemic Zygomycosis

Ellis

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Primary cutaneous zygomycosis due to Mucor circinelloides

Cited by 31 publications

References 20 publications

Mucor circinelloides Was Identified by Molecular Methods as a Cause of Primary Cutaneous Zygomycosis

Mucor circinelloides Was Identified by Molecular Methods as a Cause of Primary Cutaneous Zygomycosis

ZIGOMICOSIS CUTANEA PRIMARIA POR Rhyzopus oryzae EN UNA NIÑA CON LEUCEMIA LINFOBLASTICA AGUDA TIPO B

Systemic Zygomycosis

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