Primary epithelial salivary gland tumours in children and adolescents

Gontarz, Michał; Wyszyńska-Pawelec, Grażyna; Zapała, Jan

doi:10.1016/j.ijom.2017.06.004

Cited by 30 publications

(43 citation statements)

References 14 publications

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“…1,3,7-9,12,16-24 The pertinent data from these series are summarized in Table 2. 1-3,7-10,12,13, [16][17][18][19][20][22][23][24][25] In all of them, the parotid gland was described as the most common location for pediatric SGTs, and pleomorphic adenoma was the most frequently encountered benign neoplasm. In the majority of the series, mucoepidermoid carcinoma was reported as the most common malignant neoplasm, and infantile hemangioma was the most common mesenchymal neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of FNA cytology for diagnosis of salivary gland tumors in pediatric patients

Ronchi

Montella

Marino

et al. 2019

Cancer Cytopathology

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Background Salivary gland tumors are rare in pediatric patients and include both benign and malignant types. Although fine‐needle aspiration cytology is widely used to diagnose salivary gland tumors in adults, such diagnostic techniques in pediatric patients are still poorly applied and studied. Nevertheless, a preoperative diagnostic definition of salivary gland lesions is highly recommended to plan a correct surgical management and to avoid over‐treatment of inflammatory or reactive lesions. Methods The authors performed a retrospective analysis on a series of salivary gland lesions—both neoplastic and non‐neoplastic—in pediatric patients who underwent fine‐needle aspiration. When obtainable, the corresponding histological diagnoses were retrieved. The authors calculated the diagnostic sensitivity and specificity of fine‐needle aspiration in this clinical setting and evaluated the diagnostic agreement between cytology and histology. Results The series included 34 cases of salivary gland lesions in patients aged <20 years, including 21 benign neoplasms and 6 malignant neoplasms. Cytological samples were adequate for diagnosis in 32 of 34 cases, and a definitive cytological diagnosis was achieved in 29 of 34 cases. Cytology demonstrated a sensitivity of 0.92 and a specificity of 0.86 for the diagnosis of salivary gland tumors, and a comparison between the diagnostic performance of cytology and histology demonstrated statistically significant concordance between the 2 techniques. Conclusions Fine‐needle aspiration cytology shows high accuracy in the diagnosis of pediatric salivary gland tumors, with diagnostic sensitivity and specificity similar to those reported for adult patients.

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Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of FNA cytology for diagnosis of salivary gland tumors in pediatric patients

Ronchi

Montella

Marino

et al. 2019

Cancer Cytopathology

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“…Salivary gland tumors represent 0.3% of all malignancies and account for around 5% of all head and neck cancers. Less than 5% of the affected population is pediatric [ 2 , 4 ]. Almost 80% of salivary gland tumors arise in the parotid gland followed by the submandibular gland.…”

Section: Discussionmentioning

confidence: 99%

“…Almost 80% of salivary gland tumors arise in the parotid gland followed by the submandibular gland. Approximately 80% of all parotid tumors are benign [ 4 , 5 ]. Common benign parotid tumors include pleomorphic adenoma and pilomatrixoma.…”

Section: Discussionmentioning

confidence: 99%

“…Superficial parotidectomy with en-bloc excision of the tumor mass, with preservation of the facial nerve, is the surgery of choice for parotid pleomorphic adenoma involving the superficial lobe [ 3 ]. If the deeper lobe is involved, then total or radical parotidectomy is the procedure of choice, depending on the extent of the tumor mass and involvement of the facial nerve [ 4 ]. Following surgery, recurrence rates are as low as 0–2% [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…The facial nerve in children is located more superficially and is more sensitive to dissection/stretching than in adults. Hence, facial nerve monitoring during parotidectomy is recommended to reduce the risk of facial nerve palsy/paresis [ 4 ]. There is no role of systemic chemotherapy and radiotherapy in benign parotid tumors [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Pediatric Pleomorphic Adenoma of the Parotid: Case Report, Review of Literature and Novel Therapeutic Targets

2018

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Salivary gland tumors are extremely rare and encompass a diverse group of histologies. Less than 5% of the affected population is pediatric. We present a case of 6-year-old child with pleomorphic adenoma of the parotid. The patient underwent a superficial parotidectomy. Recurrence was not observed in the six months of follow-up. Surgery is the mainstay of the management of benign salivary gland tumors. Although novel molecular agents are being explored, personalized therapy would be a challenge due to the rarity and vast genetic/histologic variations of salivary gland tumors.

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Salivary Gland Pathology in Children and Adolescents

2021

Salivary Gland Pathology

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Primary epithelial salivary gland tumours in children and adolescents

Cited by 30 publications

References 14 publications

Diagnostic accuracy of FNA cytology for diagnosis of salivary gland tumors in pediatric patients

Diagnostic accuracy of FNA cytology for diagnosis of salivary gland tumors in pediatric patients

Pediatric Pleomorphic Adenoma of the Parotid: Case Report, Review of Literature and Novel Therapeutic Targets

Salivary Gland Pathology in Children and Adolescents

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