Primary Ewing's sarcoma of the maxilla, a rare and curable localization: report of two new cases, successfully treated by radiotherapy and systemic chemotherapy

Fiorillo, A.; Tranfa, Fausto; Canale, G; Fariello, Immacolata; D'Amore, Rosa; Chiara, Carolina De; Vassallo, Patrizia; Muto, Paolo; Rosa, Gaetano De; Bonavolontà, Giulio

doi:10.1016/0304-3835(96)04210-3

Cited by 34 publications

(15 citation statements)

References 13 publications

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“…Furthermore, since many patients with ES are young and are often physically active, the pain is frequently mistaken for bone growth or injury, resulting in a delayed or misdiagnosis (42). ES family tumors often progress rapidly and result in palpable swelling as observed in the majority of case studied (24,25,(43)(44)(45). In the oral cavity, the affected area is seen with tooth mobility (29), corroborating our findings.…”

Section: Histopathological Features Of Ewing's Sarcoma/peripheral Psupporting

confidence: 83%

“…Other authors have also misdiagnosed cases with clinical features similar to those of our case as being cysts (3,(19)(20)(21). Moreover, trauma (22)(23)(24) and acute inflammatory lesions (1, 3, 24-29, 30, 31) were also mentioned several times as provisional diagnosis. With regard to phenotypic aspects, we observed highly positive expression of CD99, vimentin, S-100 protein and NSE, representing ES family tumor with neuroectodermal differentiation or ES/pPNET (32)(33)(34)(35).…”

Section: Discussionsupporting

confidence: 55%

“…The medical literature contains only single case reports or small case series including six patients (3,24,25,36). To determine the exact number of children/young adults with primary ES or ES/pPNET of the jaws in the medical literature is very difficult, and in fact, the data reported are confusing.…”

Section: Discussionmentioning

confidence: 99%

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Ewing's Sarcoma Family Tumors in the Jaws: Case Report, Immunohistochemical Analysis and Literature Review

Casaroto

Sampieri

Soares

et al. 2017

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Section: Histopathological Features Of Ewing's Sarcoma/peripheral Psupporting

confidence: 83%

Section: Discussionsupporting

confidence: 55%

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Ewing's Sarcoma Family Tumors in the Jaws: Case Report, Immunohistochemical Analysis and Literature Review

Casaroto

Sampieri

Soares

et al. 2017

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“…Although this represents a rare site of prim ar y presentation, yet there has been a total of 22 cases of prim ary Ewing's sarcom a of the m axilla reported in the literature. 8,9 In the present series, m ost patients were treated w ith in i tia l b io p s y fo l lo w e d b y s y s te m i c chem otherapy plu s radical rad iotherapy. T his is d ue to the fa ct that m o st of ou r patien ts have large lesions (>10 cm ) of the head and neck, w here radical su rger y would be m utilating.…”

Section: Discussionmentioning

confidence: 99%

Ewing′s Sarcoma of the Head and Neck: A Retrospective Analysis of 24 Cases

Allam

El-Husseiny

Khafaga

et al. 1999

Sarcoma

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A bstractIntroduction and pur pose. Primary Ewing's sarcoma arising from the bones of the head and neck region is extremely rare representing only 1± 4% of all Ewing's sarcoma cases. Previous reports suggest a better prognosis for that particular anatomic site. The purpose of this study was to analyze the clinico-epidemiologic characteristics of that rare clinical presentation, as well as its patterns of failure and prognosis following treatment. M ater ials and methods. This study included a retrospective review of the medical records of patients with the diagnosis of Ewing's sarcoma of the head and neck region treated at King Faisal Specialist Hospital and Research Center between 1975 and Results . Out of a total number of 24 cases analyzed, there were 17 males and 7 fem ales with a ratio of 2.4:1. The m edian age at diagnosis was 16.5 years. A painful swelling was the m ost comm on clinical presentation. The m axilla was the m ost common site of presentation (9/24 cases). There were 3/24 cases who presented with metastatic disease at diagnosis. The m ajority of patients (16/24 cases) had a tum or size >10 cm . M ost patients were treated with systemic chem otherapy plus localized irradiation following an initial biopsy. W ith a m ean follow up of 3.4 years, the 5-year actuarial overall survival (OS) for the whole group was 53% , while the 5-year actuarial disease-free survival (DFS) was 30% . These ® gures were higher than those reported from our institution for young patients (£ 14 years treated for Ewing' s sarcom a in other anatom ic locations (30 % v 15% ). The response to chem otherapy was the only prognostic factor that affected both the OS and DFS. C onclusio n. The prognosis of Ewing's sarcoma of the head and neck region is slightly better than that of other anatomic sites. The response to systemic chem otherapy is one of the m ost important prognostic factors affecting both DFS and OS of Ewing's sarcoma of the head and neck. M ultimodality therapy consisting of an initial biopsy, aggressive combination chem otherapy and localized radiotherapy is the treatment of choice for Ewing's sarcoma of the head and neck region and m ay result in long-term survival.

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“…8 An increase in radiation dosage can combat these radioresistant hypoxic tumor cells. 9 However, this increase can be associated with damage to normal surrounding stroma, and presents increased risks for radiation-induced secondary cancers. Another approach to treating hypoxic tumor cells could be the specific modification of tumor radiosensitivity by the use of chemical radiosensitizers.…”

Section: Introductionmentioning

confidence: 99%

Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles for radiotherapy in hypoxic human tumor cells in vitro

Jin¹,

Bai²,

Wu³

et al. 2008

Cancer Biology & Therapy

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Radioresistant hypoxic cells may contribute to the failure of radiation therapy in controlling certain tumors. Some studies have suggested the radiosensitizing effect of paclitaxel. The poly (D,L-lactide-co-glycolide)(PLGA) nanoparticles containing paclitaxel were prepared by o/w emulsification-solvent evaporation method. The physicochemical characteristics of the nanoparticles (i.e., encapsulation efficiency, particle size distribution, morphology, in vitro release) were studied. The morphology of the two human tumor cell lines: a carcinoma cervicis (HeLa) and a hepatoma (HepG 2 ), treated with paclitaxel-loaded nanoparticles was photomicrographed. Flow cytometry was used to quantify the number of the tumor cells held in the G 2 /M phase of the cell cycle. The cellular uptake of nanoparticles was evaluated by transmission electronic microscopy. Cell viability was determined by the ability of single cell to form colonies in vitro. The prepared nanoparticles were spherical in shape with size between 200 nm and 800 nm. The encapsulation efficiency was 85.5%. The release behaviour of paclitaxel from the nanoparticles exhibited a biphasic pattern characterised by a fast initial release during the first 24 h, followed by a slower and continuous release. Co-culture of the two tumor cell lines with paclitaxel-loaded nanoparticles demonstrated that the cell morphology was changed and the released paclitaxel retained its bioactivity to block cells in the G 2 /M phase. The cellular uptake of nanoparticles was observed. The free paclitaxel and paclitaxel-loaded nanoparticles effectively sensitized hypoxic HeLa and HepG 2 cells to radiation. Under this experimental condition, the radiosensitization of paclitaxel-loaded nanoparticles was more significant than that of free paclitaxel.

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Primary Ewing's sarcoma of the maxilla, a rare and curable localization: report of two new cases, successfully treated by radiotherapy and systemic chemotherapy

Cited by 34 publications

References 13 publications

Ewing's Sarcoma Family Tumors in the Jaws: Case Report, Immunohistochemical Analysis and Literature Review

Ewing's Sarcoma Family Tumors in the Jaws: Case Report, Immunohistochemical Analysis and Literature Review

Ewing′s Sarcoma of the Head and Neck: A Retrospective Analysis of 24 Cases

Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles for radiotherapy in hypoxic human tumor cells in vitro

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