Primary Ewing’s Sarcoma of the Temporal Bone: A Rare Case Report and Literature Review

Gupta, Divya; Gulati, Achal; Purnima, .

doi:10.1007/s12070-015-0942-4

Cited by 7 publications

(13 citation statements)

References 23 publications

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“…Based on recent studies, ES may be of neuroectodermal origin, arising from primitive neural crest cells 3. A 2015 literature review by Gupta et al , which reported all the cases of primary ES of the temporal bone from 1976 to 2014 in the English language and found only 29 cases 4. Our further extensive literature review from 2014 to July 2019 revealed 14 more cases of primary ES of the temporal bone as summarised in table 1 5–16.…”

Section: Discussionmentioning

confidence: 79%

Primary Ewing’s sarcoma of the temporal bone: a rare entity and review of the literature

et al. 2019

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Ewing’s sarcoma (ES) is the second most common malignant primary bone tumour in children and adolescents. It primarily affects the diaphysis of long bones and pelvis. ES arising from temporal bone is extremely rare. To date, 43 such cases have been described in the literature. Clinical and radiological features are non-specific. Diagnosis is based mainly on immunohistochemistry. The present article presents an extremely rare case of ES of the temporal bone in a 20-year young man, and he was successfully treated with multiagent chemotherapy and radiotherapy.

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Section: Discussionmentioning

confidence: 79%

Primary Ewing’s sarcoma of the temporal bone: a rare entity and review of the literature

et al. 2019

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“…Twenty-three publications were based on a pooled total of 24 children (<18 years old) with diseases mimicking AM ( Table 2 ). 3,4,8-28 Age ranged from 10 weeks to 16 years with a male predominance (14 males, 8 females, 2 not reported). In total, 11 unique diseases were cited: acute myelogenous leukemia (AML), angiosarcoma, cranial fasciitis, Ewing sarcoma, Kawasaki disease, Langerhans cell histiocytosis (LCH), liposarcoma, melanoma, non-Hodgkin B- and T-cell lymphoma (NHL), and RMS.…”

Section: Resultsmentioning

confidence: 99%

“…28 Among children with white blood cell counts, most demonstrated leukocytosis (84.6%, 11/13). Diseases presenting with leukocytosis included AML, 10 cranial fasciitis, 12 Ewing sarcoma, 13,14 Kawasaki disease, 15 LCH, 18,19,21 NHL, 24,28 and RMS. 26 Two of 6 adults with temperature data presented with fevers (33.3%, 2/6).…”

Section: Resultsmentioning

confidence: 99%

A Review of Noninfectious Diseases Masquerading as Acute Mastoiditis

Wong

Arrighi‐Allisan

Fan

et al. 2021

Otolaryngol.--head neck surg.

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Objective Acute mastoiditis is commonly attributed to infection. Rarely do clinicians encounter cases that do not respond to traditional antibiotics or surgical management. The goal of this study was to systematically review the literature to characterize diseases masquerading as acute infectious mastoiditis. Data Sources PubMed, Embase, and Scopus. Review Methods A systematic review was performed to identify all publications that reported on diseases with presentations mimicking acute mastoiditis, defined as postauricular redness, swelling, and tenderness. We included clinical prospective studies, retrospective studies, and case series/reports. Exclusion criteria included non-English articles, letters/commentaries, abstracts, and review articles. Results Out of 3339 results, 35 studies met final inclusion criteria. In children, 11 diseases were reported to mimic mastoiditis, including solid tumors, hematologic diseases, and autoimmune/inflammatory diseases. The most common disease in children was Langerhans cell histiocytosis, followed by rhabdomyosarcoma and acute myelogenous leukemia. In adults, 8 additional diseases were reported. The most common disease in adults was squamous cell carcinoma, followed by nasopharyngeal carcinoma and Langerhans cell histiocytosis. Presenting symptoms are reviewed, as well as characteristic radiographic, laboratory, and intraoperative features that may assist with diagnosis. A diagnostic algorithm for atypical cases of acute mastoiditis is proposed. Conclusion A small but significant group of diseases in children and adults can mimic acute mastoiditis. In such cases, history and examination alone may be insufficient to reach a diagnosis, and further investigation may be necessary. Otolaryngologists should always be mindful of the possibility that noninfectious pathologies may present with a constellation of symptoms similar to mastoiditis.

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“…20-22 Additionally, while radiotherapy is generally recommended for patients with Ewing sarcoma given that the tumor cells are extremely radiosensitive, radiotherapy is not recommended in children younger than 3 years due to the unavoidable long-term consequences of radiation. 23…”

Section: Discussionmentioning

confidence: 99%

“…[20][21][22] Additionally, while radiotherapy is generally recommended for patients with Ewing sarcoma given that the tumor cells are extremely radiosensitive, radiotherapy is not recommended in children younger than 3 years due to the unavoidable long-term consequences of radiation. 23 Specific management recommendations are challenging to make due to retrospective data that are subject to confounding variables such as tumor stage and age, potential for publication bias, small number of studies, lack of controlled studies, and multiple sites of disease. Therefore, we advise clinicians to use the findings of this article with their own clinical judgment to determine which treatment strategy they should pursue.…”

Section: Managementmentioning

confidence: 99%

Ewing Sarcoma of the Craniofacial Bones: A Qualitative Systematic Review

Rehman

Osto

Parry

et al. 2021

Otolaryngol.--head neck surg.

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Objectives To conduct a systematic review on the demographics, characteristics, management, treatment, complications, and outcomes of Ewing sarcomas in the craniofacial bones. Data Sources Using Cochrane Library, EmBase, and PubMed, the authors identified 71 studies to be included. Review Methods The Cochrane Library, EmBase, and PubMed databases were used to identify literature relating to Ewing sarcomas in the craniofacial bone to conduct a systematic review. Patient demographics, clinical characteristics, and treatment strategies were extracted. Results Seventy-one studies encompassing 102 patients were identified. The most common craniofacial locations involved were the frontal bone (16.7%, n = 17), nasal cavity (16.7%, n = 17), and temporal bone (14.7%, n = 15). Stratified by location, the most common presenting symptoms were frontal bone (palpable mass, n = 8, 47.1%), nasal cavities (epistaxis, n = 9, 52.9%), and temporal bones (headache, n = 5, 33.3%). The 3 most commonly used treatment strategies were a combination of surgical intervention/radiotherapy/chemotherapy (n = 43, 43%), a combination of radiotherapy/chemotherapy (n = 18, 18%), and a combination of surgical intervention/chemotherapy (n = 15, 15%). Patients who received a combination of surgical intervention/radiotherapy/chemotherapy experienced local recurrence rate of 16.6%. However, other combinations of therapies such as surgical intervention/chemotherapy and radiotherapy/chemotherapy had a lower local recurrence rate but were limited by small sample size. Most patients (79.0%) were disease free without evidence of recurrence. Conclusion Ewing Sarcoma of the craniofacial bones has a good prognosis when treated appropriately. Given that our study was limited by retrospective data, we advise clinicians to use the findings of this article with their own clinical judgment to determine which treatment strategy they should pursue.

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Primary Ewing’s Sarcoma of the Temporal Bone: A Rare Case Report and Literature Review

Cited by 7 publications

References 23 publications

Primary Ewing’s sarcoma of the temporal bone: a rare entity and review of the literature

Primary Ewing’s sarcoma of the temporal bone: a rare entity and review of the literature

A Review of Noninfectious Diseases Masquerading as Acute Mastoiditis

Ewing Sarcoma of the Craniofacial Bones: A Qualitative Systematic Review

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