Primary Ewing sarcoma of the lung diagnosed on cytology: Case report with review of literature

Abstract

Primary Ewing sarcoma (ES) of the lung is anecdotally rare, with few cases reported in literature. This report describes a 46 year-old man who presented with cough and chest pain. CT Thorax revealed a lesion in the right lung. Ultrasound guided fineneedle aspiration of the mass and subsequent cytologic examination exhibited a small round cell morphology. Immunohistochemistry done on the cell block revealed CD 99 and FLI-1 positivity, confirming the diagnosis of ES. FISH supported the diagnosis, showing the EWSR1 rearrangement. Radiologic investigations ruled out a primary tumour elsewhere, confirming the diagnosis of primary pulmonary ES. The patient was started on chemotherapy.

Application of Anlotinib Combined With Neoadjuvant Chemotherapy in Primary EWS/PNET of Lung: A Case Report

“…Being the same as other malignant tumor occurring in chest, major clinical manifestations are cough, phlegm, chest pain or hemoptysis etc., which is often misdiagnosed as lung cancer upon preliminary diagnosis. Should the mass be large, it can cause corresponding mass effect and affect pleura, resulting in pleural effusion, causing Thoracic and back discomfort, dyspnea, fatigue and other symptoms ( 2 – 8 ). Such disease can occur at any age, mostly in children and adolescents, and peaks at the age of 20-30 years old, without gender difference.…”

Primary EWS/PNET of the lung with TP53 germline and SKT11 somatic mutation: A case report and review of the literature

“…PPES is rare, and the clinical symptoms of cough, phlegm, chest pain, hemoptysis or fatigue, etc are nonspecific. The disease has been found to occur at any age, mostly in children and adolescents, and peaks at the age of 20–30 years old, without any difference in gender 5–7 …”

“…The disease has been found to occur at any age, mostly in children and adolescents, and peaks at the age of 20-30 years old, without any difference in gender. [5][6][7] CT characterization of PPES is still limited 8-10 and the masses are usually described as being of different size, single or multiple, with clear boundaries and possible lobulation. A mass in a single lung is more common, F I G U R E 1 CT thorax.…”

“…Since Hammar et al reported the first case of PPES in 1989, 4 less than 40 cases have been reported in the literature. 5 Here, we discuss the clinical course and treatment in one case of PPES with TP53 germline and SKT11 somatic mutation.…”

18F-fluorodeoxyglucose positron emission tomography / computed tomography in primary Ewing sarcoma of the lung

“…This kind of tumor often occurs under 25, but the congenital presentation of extraosseous Ewing sarcoma, although it is exceedingly rare, reported Haas et al (2019) [1]. Multiple loci of soft tissue Ewing sarcomas develop at multiple localization: lungs [2][3][4][5][6], liver [7], and extremely rarely, primary Ewing sarcoma occurs in the female genital organs in the uterus [8].…”